Effect of Salinity Stress on Enzymes’ Activity, Ions Concentration, Oxidative Stress Parameters, Biochemical Traits, Content of Sulforaphane, and CYP79F1 Gene Expression Level in Lepidium draba Plant

2019 ◽  
Vol 39 (3) ◽  
pp. 1075-1094 ◽  
Author(s):  
Kiarash Jamshidi Goharrizi ◽  
Ali Riahi-Madvar ◽  
Fatemeh Rezaee ◽  
Rambod Pakzad ◽  
Fereshteh Jadid Bonyad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Salinity Stress ◽  
Gene Expression Level ◽  
Expression Level ◽  
Biochemical Traits ◽  
Oxidative Stress Parameters ◽  
Enzymes Activity ◽  
Lepidium Draba ◽  
Stress Parameters

scholarly journals Nigella sativaRelieves the Altered Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats Fed with a High-Fat Diet

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Mahmoud Balbaa ◽  
Marwa El-Zeftawy ◽  
Doaa Ghareeb ◽  
Nabil Taha ◽  
Abdel Wahab Mandour
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Blood Glucose ◽  
Insulin Receptor ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Diabetic Rats ◽  
High Fat ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

The black cumin (Nigella sativa) “NS” or the black seeds have many pharmacological activities such as antioxidant, anticarcinogenic, antihypertensive, and antidiabetic properties. In this work, streptozotocin-induced diabetic rats fed with a high-fat diet were treated daily with NS oil (NSO) in order to study the effect on the blood glucose, lipid profile, oxidative stress parameters, and the gene expression of some insulin receptor-induced signaling molecules. This treatment was combined also with some drugs (metformin and glimepiride) and the insulin receptor inhibitor I-OMe-AG538. The administration of NSO significantly induced the gene expression of insulin receptor compared to rats that did not receive NSO. Also, it upregulated the expression of insulin-like growth factor-1 and phosphoinositide-3 kinase, whereas the expression of ADAM-17 was downregulated. The expression of ADAM-17 is corroborated by the analysis of TIMP-3 content. In addition, the NSO significantly reduced blood glucose level, components of the lipid profile, oxidative stress parameters, serum insulin/insulin receptor ratio, and the tumor necrosis factor-α, confirming that NSO has an antidiabetic activity. Thus, the daily NSO treatment in our rat model indicates that NSO has a potential in the management of diabetes as well as improvement of insulin-induced signaling.

scholarly journals Oxidative Stress Parameters Can Predict the Response to Erythropoiesis-Stimulating Agents in Myelodysplastic Syndrome Patients

2021 ◽  
Vol 9 ◽  
Author(s):  
Ana Cristina Gonçalves ◽  
Raquel Alves ◽  
Inês Baldeiras ◽  
Joana Jorge ◽  
Bárbara Marques ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Lower Risk ◽  
Therapy Response ◽  
Predictive Biomarker ◽  
Antioxidant Defenses ◽  
Good Sensitivity ◽  
Erythropoiesis Stimulating Agents ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Oxidative stress has been implicated in the development of several types of cancer, including myelodysplastic syndromes (MDS), as well as in the resistance to treatment. In this work, we assessed the potential of oxidative stress parameters to predict the response to erythropoiesis-stimulating agents (ESAs) in lower-risk MDS patients. To this end, we analyzed the systemic levels of reactive species (peroxides and NO), antioxidant defenses (uric acid, vitamin E, vitamin A, GSH, GSSG, TAS, as well as GPX and GR activities], and oxidative damage (8-OH-dG and MDA) in 66 MDS patients, from those 44 have been treated with ESA. We also calculated the peroxides/TAS and NO/TAS ratios and analyzed the gene expression of levels of the redox regulators, NFE2L2 and KEAP1. We found that patients that respond to ESA treatment showed lower levels of plasma peroxides (p < 0.001), cellular GSH (p < 0.001), and cellular GR activity (p = 0.001) when compared to patients who did not respond to ESA treatment. ESA responders also showed lower levels of peroxides/TAS ratio (p < 0.001) and higher levels of the expression of the NFE2L2 gene (p = 0.001) than those that did not respond to ESA treatment. The levels of plasmatic peroxides shown to be the most accurate biomarker of ESA response, with good sensitivity (80%) and specificity (100%) and is an independent biomarker associated with therapy response. Overall, the present study demonstrated a correlation between oxidative stress levels and the response to ESA treatment in lower-risk MDS patients, with the plasmatic peroxides levels a good predictive biomarker of drug (ESA) response.

Does human myocardium show a gender dependent modification of oxidative stress parameters?

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
K. Buschmann ◽  
Y. Gramlich ◽  
M. Oelze ◽  
A. Daiber ◽  
T. Münzel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Myocardium ◽  
Oxidative Stress Parameters ◽  
Dependent Modification ◽  
Stress Parameters

Serum Interleukin-37 (IL-37) levels were increased and correlated with oxidative stress parameters in Hashimoto's Thyroiditis (HT) patients

2017 ◽  
Author(s):  
Rosaria Maddalena Ruggeri ◽  
Teresa Manuela Vicchio ◽  
Angela Alibrandi ◽  
Salvatore Giovinazzo ◽  
Rosaria Certo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Evaluation of oxidative stress parameters in subacute thyroiditis patients

2019 ◽  
Author(s):  
Murat Dağdeviren ◽  
Arzu Or Koca ◽  
Tolga Akkan ◽  
İhsan Ateş ◽  
Salim Neşelioğlu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Subacute Thyroiditis ◽  
Oxidative Stress Parameters ◽  
Stress Parameters
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