Preoperative positive urine cytology is a risk factor for subsequent development of bladder cancer after nephroureterectomy in patients with upper urinary tract urothelial carcinoma

2011 ◽  
Vol 30 (2) ◽  
pp. 271-275 ◽  
Author(s):  
Yasuyuki Kobayashi ◽  
Takashi Saika ◽  
Yoshiyuki Miyaji ◽  
Michinao Saegusa ◽  
Ryoji Arata ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Risk Factor ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Subsequent Development ◽  
Upper Urinary Tract ◽  
Urine Cytology ◽  
Positive Urine ◽  
Urinary Tract Urothelial Carcinoma

scholarly journals Predictive Value of Preoperative Positive Urine Cytology for Development of Bladder Cancer After Nephroureterectomy in Patients With Upper Urinary Tract Urothelial Carcinoma: A Prognostic Nomogram Based on a Retrospective Multicenter Cohort Study and Systematic Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Bo Fan ◽  
Yuanbin Huang ◽  
Shuang Wen ◽  
Qiliang Teng ◽  
Xinrui Yang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Urinary Tract ◽  
Meta Analysis ◽  
Upper Urinary Tract ◽  
Urine Cytology ◽  
Biological Behavior ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Positive Urine ◽  
Urinary Tract Urothelial Carcinoma

BackgroundUpper urinary tract urothelial carcinoma (UUT-UC) is a rare and severe urinary malignancy. Several studies have explored the relationship between preoperative urine cytology and intravesical recurrence (IVR) in patients with UUT-UC. However, the results of these studies are controversial or even contradictory, and investigations with UUT-UC patients in northeast China are rare.MethodsWe first estimated the prognostic significance of preoperative urine cytology in the outcomes of intravesical recurrence in 231 UUT-UC patients (training cohort = 142, validation cohort = 89) after radical nephroureterectomy (RNU) by the nomogram model. Subsequently, we quantitatively combined our results with the published data after searching several databases to assess whether preoperative positive urine cytology was associated with poor intravesical recurrence-free survival and a high risk of tumor malignant biological behavior.ResultsFirstly, the multicenter retrospective cohort study demonstrated that preoperative positive urine cytology correlated with poor intravesical recurrence-free survival and can serve as significant independent predictors of IVR by Kaplan–Meier curves and Cox regression analysis. The construction of the nomogram demonstrated that predictive efficacy and accuracy were significantly improved when preoperative urine cytology was combined. Meanwhile, meta-analysis showed that preoperative positive urine cytology was associated with a 49% increased risk of IVR. In the subgroup analysis by region, study type, and sample size, the pooled hazard ratios (HRs) were statistically significant for the Japan subgroup (HR 1.32), China subgroup (HR 1.88), cohort study subgroup (HR 1.45), and the single-arm study subgroup (HR 1.63).ConclusionsPreoperative urine cytology was validated as a potential predictor of intravesical recurrence in patients with UUT-UC after RNU, although these results need to be generalized with caution. Large, prospective trials are required to further confirm its significance in prognosis and tumor malignant biological behavior.

Impact of Previous, Simultaneous or Subsequent Bladder Cancer on Prognosis after Radical Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

2019 ◽  
Vol 202 (6) ◽  
pp. 1127-1135 ◽  
Author(s):  
Kentaro Kuroiwa ◽  
Junichi Inokuchi ◽  
Hiroyuki Nishiyama ◽  
Takahiro Kojima ◽  
Yoshiyuki Kakehi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Upper Urinary Tract ◽  
Radical Nephroureterectomy ◽  
Urinary Tract Urothelial Carcinoma

Long-term effects of Bacilles Calmette-Guerin perfusion therapy for upper urinary tract urothelial carcinoma in situ.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 343-343
Author(s):  
Takahiro Yoneyama ◽  
Yuki Tobisawa ◽  
Tohru Yoneyama ◽  
Hayato Yamamoto ◽  
Atsushi Imai ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Side Effects ◽  
Urothelial Carcinoma ◽  
Carcinoma In Situ ◽  
Upper Urinary Tract ◽  
Urine Cytology ◽  
Long Term Effects ◽  
Urinary Tract Urothelial Carcinoma

343 Background: Bacillus Calmette-Guerin (BCG) therapy has already been established as a treatment for muscle noninvasive bladder cancer. Although there are several reports indicating the effectiveness of BCG perfusion therapy for the upper urinary tract urothelial carcinoma in situ(CIS), it is not well established yet. We conducted a retrospective study to assess the long-term effects of BCG perfusion therapy for the upper urinary tract CIS. Methods: Thirty-one subjects (24 male, 7 female) who received BCG perfusion therapy for the upper urinary tract CIS from December 1997 to December 2013 were enrolled. 11 subjects had the entire urinary tract CIS, 8 had bilateral, 12 had unilateral CIS of the urinary tract. The average period of observation was 49.9 months (ranging from 5 to 196 months), and the average subject age was 74.8 years (ranging from 56 to 90 years). We used a double-J catheter for 22 cases, a transvesical single-J catheter whose curl was positions in an upper calyx for 8 cases, and a straight ureteral catheter inserted for ureterocutaneostomy for 1 case. We used 80 mg of BCG for the first five cases, 40 mg for the late 26 cases. Urine cytology was performed to assess the treatment validity. Results: Of the 31 cases, the treatment protocol was completed in 27 cases. Urine cytology tests became negative in 25 of the 31 subjects (80.7%) who underwent upper urinary tract perfusion. Among these 22 subjects who had negative tests, 8 subjects had a recurrence in their upper urinary tracts. Side effects were observed in 28 subjects (90.3%), and the most common side effect was bladder irritation. Localized renal tuberculosis, which was successfully treated with conservative therapy, was seen in two cases. Conclusions: BCG perfusion therapy for the upper urinary tract CIS is effective. However, severe side effects are possible, and careful observation is essential while using this therapy.

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