Laparoscopic vs. open surgery for T4 colon cancer: A propensity score analysis

Abstract Background: A large number of patients suffer recurrence after curative resection, and mortality from colon cancer remains high. The role of cancer-associated malnutrition such as the neutrophil-to-lymphocyte ratio (NLR) in cancer recurrence and death has been increasingly recognized. This study aimed to analyze long-term oncologic outcomes of Stage II-III colon cancer to examine the prognostic value of NLR using a propensity score analysis.Methods: A total of 442 patients with colon cancer underwent radical surgery between 2000 and 2014 at Tokyo Medical University Hospital. Long-term oncologic outcomes of these patients were evaluated according to NLR values. A cut-off NLR of 3.0 was used based on receiver operating characteristic curve analysis. A propensity score analysis according to tumor sidedness was also performed. Primary outcomes were overall survival (OS) and relapse-free survival (RFS). Results: Patients with lower NLR values (“lower NLR group”) were more likely to have lymph node metastasis compared to those with higher NLR values (“higher NLR group”) before case matching. After case matching, clinical outcomes were similar between the two groups. There were no significant difference in 5-year OS and 5-year RFS rates between the two groups before case matching based on propensity scores. After case matching, 5-year OS rates were 94.5% in the lower NLR group (n = 135) and 87.0% in the higher NLR group (n = 135), showing a significant difference (p = 0.042). Five-year RFS rates were 87.8% in the lower NLR group and 77.9% in the higher NLR group, also showing a significant difference (p = 0.032). Among patients with left-sided colon cancer, 5-year OS and 5-year RFS rates were 95.2% and 87.3% in the lower NLR group (n = 88), respectively, and 86.4% and 79.2% in the higher NLR group (n = 71), respectively, showing significant differences (p = 0.014 and p = 0.047, respectively).Conclusions: The NLR is an important prognostic factor for advanced colon cancer, especially for left-sided colon cancer.

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Laparoscopic versus Open Colectomy for Elderly Patients with Colon Cancer: A Propensity Score Analysis with the Controlling Nutritional Status (CONUT) Score

Nutrition and Cancer ◽

10.1080/01635581.2020.1743868 ◽

2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Tomoko Horie ◽

Dai Shida ◽

Yuka Ahiko ◽

Yasuyuki Takamizawa ◽

Manabu Inoue ◽

...

Keyword(s):

Colon Cancer ◽

Propensity Score ◽

Nutritional Status ◽

Elderly Patients ◽

Propensity Score Analysis ◽

Open Colectomy ◽

Score Analysis ◽

Conut Score

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Prognostic impact of lymph node dissection is different for male and female colon cancer patients: a propensity score analysis in a multicenter retrospective study

International Journal of Colorectal Disease ◽

10.1007/s00384-016-2558-x ◽

2016 ◽

Vol 31 (6) ◽

pp. 1149-1155 ◽

Cited By ~ 4

Author(s):

Soichiro Ishihara ◽

Kensuke Otani ◽

Koji Yasuda ◽

Takeshi Nishikawa ◽

Toshiaki Tanaka ◽

...

Keyword(s):

Colon Cancer ◽

Lymph Node ◽

Retrospective Study ◽

Propensity Score ◽

Cancer Patients ◽

Propensity Score Analysis ◽

Prognostic Impact ◽

Node Dissection ◽

Male And Female ◽

Score Analysis

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Neutrophil-to-lymphocyte ratio is a prognostic factor for colon cancer: a propensity score analysis

10.21203/rs.3.rs-22564/v3 ◽

2020 ◽

Author(s):

Junichi Mazaki ◽

Kenji katsumata ◽

Kenta Kasahara ◽

Tomoya Tago ◽

Takahiro Wada ◽

...

Keyword(s):

Colon Cancer ◽

Prognostic Factor ◽

Propensity Score ◽

Propensity Score Analysis ◽

Neutrophil To Lymphocyte Ratio ◽

Oncologic Outcomes ◽

Lymphocyte Ratio ◽

Score Analysis ◽

Significant Difference

Abstract Background: A large number of patients suffer recurrence after curative resection, and mortality from colon cancer remains high. The role of systemic inflammatory response, as reflected by neutrophil-to-lymphocyte ratio (NLR), in cancer recurrence and death has been increasingly recognized. This study aimed to analyze long-term oncologic outcomes of Stage II-III colon cancer to examine the prognostic value of NLR using a propensity score analysis.Methods: A total of 375 patients with colon cancer underwent radical surgery between 2000 and 2014 at Tokyo Medical University Hospital. Long-term oncologic outcomes of these patients were evaluated according to NLR values. A cut-off NLR of 3.0 was used based on receiver operating characteristic curve analysis. Primary outcomes were overall survival (OS) and relapse-free survival (RFS). An analysis of outcomes according to tumor sidedness was also performed.Results: Patients with lower NLR values (“lower NLR group”) were more likely to have lymph node metastasis compared to those with higher NLR values (“higher NLR group”) before case matching. After case matching, clinical outcomes were similar between the two groups. There were no significant differences in 5-year OS and 5-year RFS rates between the two groups before case matching based on propensity scores. After case matching, 5-year OS rates were 94.5% in the lower NLR group (n = 135) and 87.0% in the higher NLR group (n = 135), showing a significant difference (p = 0.042). Five-year RFS rates were 87.8% in the lower NLR group and 77.9% in the higher NLR group, also showing a significant difference (p = 0.032). Among patients with left-sided colon cancer in the matched cohort, 5-year OS and 5-year RFS rates were 95.2% and 87.3% in the lower NLR group (n = 88), respectively, and 86.4% and 79.2% in the higher NLR group (n = 71), respectively, showing significant differences (p = 0.014 and p = 0.047, respectively).Conclusions: The NLR is an important prognostic factor for advanced colon cancer, especially for left-sided colon cancer.

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Neutrophil-to-lymphocyte ratio is a prognostic factor for colon cancer: a propensity score analysis

10.21203/rs.3.rs-22564/v2 ◽

2020 ◽

Author(s):

Junichi Mazaki ◽

Kenji katsumata ◽

Kenta Kasahara ◽

Tomoya Tago ◽

Takahiro Wada ◽

...

Keyword(s):

Colon Cancer ◽

Prognostic Factor ◽

Propensity Score ◽

Propensity Score Analysis ◽

Neutrophil To Lymphocyte Ratio ◽

Oncologic Outcomes ◽

Lymphocyte Ratio ◽

Score Analysis ◽

Significant Difference

Abstract Background: A large number of patients suffer recurrence after curative resection, and mortality from colon cancer remains high. The role of systemic inflammatory response, as reflected by neutrophil-to-lymphocyte ratio (NLR), in cancer recurrence and death has been increasingly recognized. This study aimed to analyze long-term oncologic outcomes of Stage II-III colon cancer to examine the prognostic value of NLR using a propensity score analysis.Methods: A total of 375 patients with colon cancer underwent radical surgery between 2000 and 2014 at Tokyo Medical University Hospital. Long-term oncologic outcomes of these patients were evaluated according to NLR values. A cut-off NLR of 3.0 was used based on receiver operating characteristic curve analysis. Primary outcomes were overall survival (OS) and relapse-free survival (RFS). An analysis of outcomes according to tumor sidedness was also performed.Results: Patients with lower NLR values (“lower NLR group”) were more likely to have lymph node metastasis compared to those with higher NLR values (“higher NLR group”) before case matching. After case matching, clinical outcomes were similar between the two groups. There were no significant differences in 5-year OS and 5-year RFS rates between the two groups before case matching based on propensity scores. After case matching, 5-year OS rates were 94.5% in the lower NLR group (n = 135) and 87.0% in the higher NLR group (n = 135), showing a significant difference (p = 0.042). Five-year RFS rates were 87.8% in the lower NLR group and 77.9% in the higher NLR group, also showing a significant difference (p = 0.032). Among patients with left-sided colon cancer in the matched cohort, 5-year OS and 5-year RFS rates were 95.2% and 87.3% in the lower NLR group (n = 88), respectively, and 86.4% and 79.2% in the higher NLR group (n = 71), respectively, showing significant differences (p = 0.014 and p = 0.047, respectively).Conclusions: The NLR is an important prognostic factor for advanced colon cancer, especially for left-sided colon cancer.

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Neutrophil-to-lymphocyte ratio is a prognostic factor for colon cancer: a propensity score analysis

BMC Cancer ◽

10.1186/s12885-020-07429-5 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Junichi Mazaki ◽

Kenji Katsumata ◽

Kenta Kasahara ◽

Tomoya Tago ◽

Takahiro Wada ◽

...

Keyword(s):

Colon Cancer ◽

Prognostic Factor ◽

Propensity Score ◽

Propensity Score Analysis ◽

Neutrophil To Lymphocyte Ratio ◽

Oncologic Outcomes ◽

Lymphocyte Ratio ◽

Score Analysis ◽

Significant Difference

Abstract Background A large number of patients suffer recurrence after curative resection, and mortality from colon cancer remains high. The role of systemic inflammatory response, as reflected by neutrophil-to-lymphocyte ratio (NLR), in cancer recurrence and death has been increasingly recognized. This study aimed to analyze long-term oncologic outcomes of Stage II-III colon cancer to examine the prognostic value of NLR using a propensity score analysis. Methods A total of 375 patients with colon cancer underwent radical surgery between 2000 and 2014 at Tokyo Medical University Hospital. Long-term oncologic outcomes of these patients were evaluated according to NLR values. A cut-off NLR of 3.0 was used based on receiver operating characteristic curve analysis. Primary outcomes were overall survival (OS) and relapse-free survival (RFS). An analysis of outcomes according to tumor sidedness was also performed. Results Patients with lower NLR values (“lower NLR group”) were more likely to have lymph node metastasis compared to those with higher NLR values (“higher NLR group”) before case matching. After case matching, clinical outcomes were similar between the two groups. There were no significant differences in 5-year OS and 5-year RFS rates between the two groups before case matching based on propensity scores. After case matching, 5-year OS rates were 94.5% in the lower NLR group (n = 135) and 87.0% in the higher NLR group (n = 135), showing a significant difference (p = 0.042). Five-year RFS rates were 87.8% in the lower NLR group and 77.9% in the higher NLR group, also showing a significant difference (p = 0.032). Among patients with left-sided colon cancer in the matched cohort, 5-year OS and 5-year RFS rates were 95.2 and 87.3% in the lower NLR group (n = 88), respectively, and 86.4 and 79.2% in the higher NLR group (n = 71), respectively, showing significant differences (p = 0.014 and p = 0.047, respectively). Conclusions The NLR is an important prognostic factor for advanced colon cancer, especially for left-sided colon cancer.

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