Progastrin: a potential predictive marker of liver metastasis in colorectal cancer

Anastomotic fistula is a dreadful complication of colon and rectal surgery that can put life into danger, being common after colorectal surgery. The preoperative lymphocyte neutrophil ratio (NLR) is known as a prognostic marker for colorectal cancer patients. The existence of a predictive marker of anastomotic fistula in colorectal cancer patients is not fully undestood, so we proposed to investigate the utility of preoperative NLR as a predictor of anastomotic fistula formation. This study the Neutrophils and lymphocytes were detected from periferic blood using flow citometry. We retrospectively evaluated 161 patients with colorectal cancer, who were treated curatively, in which at least one anastomosis was performed, comparing NLR values between patients who had fistula and those with normal healing, then comparing the group with low NLR, with the group with increased NLR, after finding the optimal value of NLR using the ROC curve.The optimal value of the NLR after establishing the cutoff value was 3.07. Between the low NLR group (n=134) and the high NLR group (n=27), were observed statistically significant differences in fistula (p [0.001) and death (p=0.001). The odds ratio for failure in the group with increased NLR was 10.37, which means that patients with NLR]3.54 have a chance of developing anastomotic fistula greater than 10.37 comparable to patients with lower NLR. We suggest the preoperative use of NLR can be used as a predictive marker of anastomotic fistula than can increase the quality of preoperative preparation and therefore the establishment of the optimal surgical technique that can lead to anastomotic fistula risk decrease.

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The prognostic role of KRAS and BRAF in patients undergoing surgical resection of colorectal cancer liver metastasis: a systematic review and meta-analysis

Annals of Oncology ◽

10.1093/annonc/mdw335.08 ◽

2016 ◽

Vol 27 ◽

pp. iv41

Author(s):

F. Passiglia ◽

A. Galvano ◽

S. Rizzo ◽

A. Listì ◽

N. Barraco ◽

...

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Liver Metastasis ◽

Surgical Resection ◽

Meta Analysis ◽

Prognostic Role ◽

Colorectal Cancer Liver Metastasis

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L‑Lactate dehydrogenase B may be a predictive marker for sensitivity to anti‑EGFR monoclonal antibodies in colorectal cancer cell lines

Oncology Letters ◽

10.3892/ol.2019.10075 ◽

2019 ◽

Cited By ~ 2

Author(s):

Ayumu Nagamine ◽

Takuya Araki ◽

Daisuke Nagano ◽

Mitsue Miyazaki ◽

Koujirou Yamamoto

Keyword(s):

Colorectal Cancer ◽

Monoclonal Antibodies ◽

Lactate Dehydrogenase ◽

Cell Lines ◽

Cancer Cell ◽

Predictive Marker ◽

Cancer Cell Lines ◽

Colorectal Cancer Cell ◽

Colorectal Cancer Cell Lines

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Stem cell gene Girdin: a potential early liver metastasis predictor of colorectal cancer

Molecular Biology Reports ◽

10.1007/s11033-012-1731-8 ◽

2012 ◽

Vol 39 (9) ◽

pp. 8717-8722 ◽

Cited By ~ 13

Author(s):

Chen Liu ◽

Hongpeng Xue ◽

Yixia Lu ◽

Baorong Chi

Keyword(s):

Colorectal Cancer ◽

Stem Cell ◽

Liver Metastasis ◽

Cell Gene ◽

Stem Cell Gene

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Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives

Cancers ◽

10.3390/cancers13102418 ◽

2021 ◽

Vol 13 (10) ◽

pp. 2418

Author(s):

Xuezhen Zeng ◽

Simon E. Ward ◽

Jingying Zhou ◽

Alfred S. L. Cheng

Keyword(s):

Colorectal Cancer ◽

Liver Metastasis ◽

Cancer Patients ◽

High Recurrence Rate ◽

Immune Microenvironment ◽

Liver Sinusoidal Endothelial Cells ◽

Premetastatic Niche ◽

Cancer Pathogenesis ◽

Colorectal Cancer Patients ◽

The Impact

A drastic difference exists between the 5-year survival rates of colorectal cancer patients with localized cancer and distal organ metastasis. The liver is the most favorable organ for cancer metastases from the colorectum. Beyond the liver-colon anatomic relationship, emerging evidence highlights the impact of liver immune microenvironment on colorectal liver metastasis. Prior to cancer cell dissemination, hepatocytes secrete multiple factors to recruit or activate immune cells and stromal cells in the liver to form a favorable premetastatic niche. The liver-resident cells including Kupffer cells, hepatic stellate cells, and liver-sinusoidal endothelial cells are co-opted by the recruited cells, such as myeloid-derived suppressor cells and tumor-associated macrophages, to establish an immunosuppressive liver microenvironment suitable for tumor cell colonization and outgrowth. Current treatments including radical surgery, systemic therapy, and localized therapy have only achieved good clinical outcomes in a minority of colorectal cancer patients with liver metastasis, which is further hampered by high recurrence rate. Better understanding of the mechanisms governing the metastasis-prone liver immune microenvironment should open new immuno-oncology avenues for liver metastasis intervention.

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LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit

Oncogene ◽

10.1038/s41388-021-01859-6 ◽

2021 ◽

Author(s):

Senlin Zhao ◽

Bingjie Guan ◽

Yushuai Mi ◽

Debing Shi ◽

Ping Wei ◽

...

Keyword(s):

Colorectal Cancer ◽

Liver Metastasis ◽

Positive Feedback ◽

Feedback Loop ◽

Metastatic Tumor ◽

Feedback Circuit ◽

Colorectal Cancer Liver Metastasis ◽

Positive Feedback Circuit

AbstractGlycolysis plays a crucial role in reprogramming the metastatic tumor microenvironment. A series of lncRNAs have been identified to function as oncogenic molecules by regulating glycolysis. However, the roles of glycolysis-related lncRNAs in regulating colorectal cancer liver metastasis (CRLM) remain poorly understood. In the present study, the expression of the glycolysis-related lncRNA MIR17HG gradually increased from adjacent normal to CRC to the paired liver metastatic tissues, and high MIR17HG expression predicted poor survival, especially in patients with liver metastasis. Functionally, MIR17HG promoted glycolysis in CRC cells and enhanced their invasion and liver metastasis in vitro and in vivo. Mechanistically, MIR17HG functioned as a ceRNA to regulate HK1 expression by sponging miR-138-5p, resulting in glycolysis in CRC cells and leading to their invasion and liver metastasis. More interestingly, lactate accumulated via glycolysis activated the p38/Elk-1 signaling pathway to promote the transcriptional expression of MIR17HG in CRC cells, forming a positive feedback loop, which eventually resulted in persistent glycolysis and the invasion and liver metastasis of CRC cells. In conclusion, the present study indicates that the lactate-responsive lncRNA MIR17HG, acting as a ceRNA, promotes CRLM through a glycolysis-mediated positive feedback circuit and might be a novel biomarker and therapeutic target for CRLM.

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