Markers of metabolic syndrome in obese children before and after 1-year lifestyle intervention program

2010 ◽  
Vol 50 (6) ◽  
pp. 391-400 ◽  
Author(s):  
C. Pedrosa ◽  
B. M. P. M. Oliveira ◽  
I. Albuquerque ◽  
C. Simões-Pereira ◽  
M. D. Vaz-de-Almeida ◽  
...  
2019 ◽  
Vol 12 (3) ◽  
pp. 1317-1328
Author(s):  
Inas R. El- Alameey ◽  
Hanaa H. Ahmed ◽  
Mones M. Abushady

Brain derived neurotrophic factor (BDNF) is a neurotrophin probably concerned in the pathophysiology of obesity and metabolic syndrome (MS) in adults. The aim was to explore serum BDNF relationship with metabolic syndrome components before and after one-year of the lifestyle intervention program in obese children. Forty obese children and forty age and gender-matched lean controls were studied. Anthropometric parameters, blood pressure, fasting blood glucose, serum insulin, lipid profile, insulin resistance (HOMA-IR), and serum BDNF, before and after one year of diet control and physical activity were measured. At baseline, fasting glucose, insulin, HOMA-IR, cholesterol, LDL, triglycerides were significantly higher in obese children relative to controls (P=0.00). Serum BDNF concentration was significantly lower in obese children than in lean controls (P=0.00), and its mean concentration of the subjects with MS was significantly lower than those without MS, and control group (P< 0.001). Linear regression analysis suggested that high waist: hip ratio, body adiposity index, fat percentage, diastolic BP, fasting blood glucose, LDL and HOMA-IR are good predictors for decreased serum BDNF concentration in obese children. After one-year intervention program, the obese group showed a significant increase in serum BDNF, and HDL, paralleled by a significant decline in fasting glucose, insulin, HOMA-IR, cholesterol, LDL, triglycerides as compared to the baseline (P =0.00). Serum BDNF was lower in obese children than in lean controls, and seemed to be linked with the metabolic syndrome components. One-year lifestyle intervention program succeeded to enhance BDNF serum concentration in these children.


2010 ◽  
Vol 119 (04) ◽  
pp. 238-242 ◽  
Author(s):  
S. Ehehalt ◽  
R. Schweizer ◽  
G. Blumenstock ◽  
C. Pfaff ◽  
N. Schurr ◽  
...  

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Luc J Martin ◽  
Shauna M Burke ◽  
Sheree Shapiro ◽  
Albert V Carron ◽  
Jennifer D Irwin ◽  
...  

2009 ◽  
Vol 219 (2) ◽  
pp. 155-164 ◽  
Author(s):  
Hiroko Fujii ◽  
Yasuo Haruyama ◽  
Takashi Muto ◽  
Emiko Kobayashi ◽  
Kaori Ishisaki ◽  
...  

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