Time-dependent cellular response in the liver and heart in a dietary-induced obese mouse model: the potential role of ER stress and autophagy

Estrogen provides many beneficial effects early in life by regulating normal tissue development and several physiological functions. While estrogen replacement therapy (ERT) in women was expected to reduce the health risks associated with the age-related decline in estrogen levels during menopause, ERT also resulted in increased progression to other types of diseases. Hence, distinguishing the signaling pathways that regulate the beneficial and detrimental effects of estrogen is important for developing interventions that selectively harness the hormone's beneficial effects, while minimizing its side effects. Estrogen can minimize mitochondrial dysfunction, which is thought to contribute to aging phenotypes. Decline in estrogen levels during menopause may lead to progressive mitochondrial dysfunction and may permanently alter cellular response, including that of estrogen (i.e., ERT). This review discusses the interplay between estrogen and mitochondrial function during the aging process and suggests a potential role of mitochondria in influencing the pleiotropic action of estrogen.

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Time-Dependent Compensatory Responses to Chronic Neuroinflammation in Hippocampus and Brainstem: The Potential Role of Glutamate Neurotransmission

Journal of Alzheimer’s Disease & Parkinsonism ◽

10.4172/2161-0460.1000110 ◽

2013 ◽

Vol 03 (01) ◽

Cited By ~ 9

Author(s):

Holly M Brothers

Keyword(s):

Potential Role ◽

Time Dependent ◽

Compensatory Responses ◽

Chronic Neuroinflammation ◽

Glutamate Neurotransmission

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Carbamoylcholine and gastrin induce inositol lipid turnover in canine gastric parietal cells

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1988.255.1.g99 ◽

1988 ◽

Vol 255 (1) ◽

pp. G99-G105 ◽

Cited By ~ 2

Author(s):

T. Chiba ◽

S. K. Fisher ◽

J. Park ◽

E. B. Seguin ◽

B. W. Agranoff ◽

...

Keyword(s):

Potential Role ◽

Inositol Phosphates ◽

Selective Reduction ◽

Parietal Cells ◽

Time Dependent ◽

Cell Uptake ◽

Inositol Phospholipids ◽

Lipid Turnover ◽

Gastric Parietal Cells

The potential role of inositol phospholipid turnover in mediating acid secretion was examined in a preparation enriched for isolated canine gastric parietal cells. The stimulatory effects of carbamoylcholine (carbachol) and gastrin on parietal cell uptake of [14C]aminopyrine were linked to dose- and time-dependent selective reduction in cellular phosphatidylinositol content, although the specific fatty acid composition of the phosphoinositides was not altered. Analysis of [3H]inositol phosphates accumulated in cells prelabeled with [3H]inositol revealed an increase in labeled inositol trisphosphate by 5 min of incubation with either carbachol or gastrin. Furthermore, after preincubation of parietal cells in medium containing [32P]orthophosphate, the two secretagogues elicited a time-dependent decrease in 32P labeling of phosphatidylinositol 4,5-bisphosphate and concomitant increase in labeling of phosphatidic acid. These data demonstrate that the acid secretagogue actions of carbachol and gastrin are correlated with turnover of cellular inositol phospholipids in a preparation consisting predominantly of parietal cells.

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