The impact of paratracheal lymph node metastasis in squamous cell carcinoma of the hypopharynx

Abstract Objective: The main objective of this study was to analyze the clinical behavior and the impact of nodal metastasis on the prognosis of upper alveolus squamous cell carcinoma (SCC). Materials and Methods: The medical records of 110 patients with SCC of the upper alveolus (International Classification of Diseases-10-C03.0) diagnosed during 2010–2015 were reviewed. Survival analysis was done using the Kaplan–Meier method and was compared using log rank-test. P < 0.05 was considered statistically significant. Results: Of the 110 patients, 59 were males and 51 were females. Forty-six (41.8%) patients presented with lymph node metastasis. Fifty-three (51.8%) patients presented in Stage IVA, thirty (27.3%) patients in Stage IVB, ten (9.1%) patients in Stage III, 12 (10.9%) patients in Stage II. The 5-year overall survival (OS) was 71.1% in Stage II, in Stage III it was 65.6%, in Stage it was IVA 56.7%, and in Stage IVB it was 19.4% (P = 0.02). The 5-year OS for node negative compared with node positive was 66.3% versus 37.3%, respectively (P = 0.019). Conclusion: Presence of lymph node metastasis is associated with lower survival rates. Adequate surgical resection with adjuvant treatment, where necessary, offers the best chance of disease control.

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Impact of Histological and Molecular Parameters on Prognosis of Oral Squamous Cell Carcinoma: Analysis of 290 Cases

BioMed Research International ◽

10.1155/2020/2059240 ◽

2020 ◽

Vol 2020 ◽

pp. 1-13

Author(s):

B. S. M. S. Siriwardena ◽

H. D. N. U. Karunathilaka ◽

P. V. R. Kumarasiri ◽

W. M. Tilakaratne

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Tumour Size ◽

Survival Rates ◽

Node Metastasis ◽

The Impact

Background. Nodal metastasis is a critical factor in predicting the prognosis of oral squamous cell carcinoma (OSCC). When patients present with a clinically positive neck, the treatment of choice is radical neck dissection. However, management of a clinically negative neck is still a subject of significant controversy. Aim. This study was carried out in order to propose a model to predict regional lymph node metastasis of OSCC using histological parameters such as tumour stage, tumour size, pattern of invasion (POI), differentiation of tumour, and host immune response, together with the expression levels of six biomarkers (periostin, HIF-1α, MMP-9, β-catenin, VEGF-C, and EGFR), and, furthermore, to compare the impact of all these parameters on recurrence and 3 yr and 5 yr survival rates. Materials and Method. Histological materials collected from the archives were used to evaluate histological parameters and immunohistochemical profiles. Standard methods were used for immunohistochemistry and for evaluation of results. Data related to recurrence and survival (3 and 5 years) was also recorded. Clinical data was collected from patients’ records. Results. Male to female ratio was 3 : 1. The commonest site of OSCC was the buccal mucosa, and majority of them were T3 or T4 tumours presented at stage 4. 62.5% of the tumours were well differentiated. Three-year and 5-year survival rates were significantly associated with lymph node metastasis and recurrence. POI was significantly correlated with tumour size, stage, 3-year survival, EGFR, HIF-1α, periostin, and MMP-9 ( p < 0.05 ). Expression of EGFR showed a direct association with metastasis ( p < 0.05 ). Conclusion. POI, level of differentiation, and expression of EGFR are independent prognostic markers for lymph node metastasis. Therefore, these parameters may help in treatment planning of a clinically negative neck.

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PS02.225: PROGNOSTIC VALUE OF LYMPH NODE METASTASIS IN DIFFERENT SITES IN PATHOLOGICAL T3 ESOPHAGEAL SQUAMOUS CELL CARCINOMA PATIENTS

Diseases of the Esophagus ◽

10.1093/dote/doy089.ps02.225 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 185-186

Author(s):

Ying-Jian Wang ◽

Kun-Kun Li ◽

Xue-Hai Liu ◽

Wei Guo

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Rank Test ◽

Node Metastasis ◽

Log Rank Test ◽

The Impact

Abstract Background The aim of this study was to evaluate the impact of different sites of lymph node metastasis in pathological T3 (pT3) esophageal squamous cell carcinoma patients (ESCC). Methods We retrospectively reviewed 300 consecutive ESCC patients who underwent radical minimally invasive esophagectomy (MIE) and two-field lymphadenectomy from 2010 to 2015. After exclusion, 111 cases were analyzed. Patients were divided into 3 groups (mediastinal metastasis, abdominal metastasis, and simultaneous metastasis) according to their lymph node metastatic sites. Disease-free survival (DFS) and disease-specific survival (DSS) were analyzed. Results The results showed that the incidence of lymph node metastasize to mediastinum, abdomen, and simultaneous was 55 (49.5%), 21(18.9%), 35(31.6%), respectively. Patients in simultaneous metastasis group had a higher cancer recurrence (log-rank test; P = 0.0341; Figure 1A) than mediastinum and abdomen metastasis group. Similarly, patients in simultaneous metastasis group had greater rate of cancer-related death (log-rank test; P = 0.0177; Figure 1B) than mediastinum and abdomen metastasis group. In the multivariate model, metastasis site was an independent risk factor in both DFS (P = 0.0402; HR, 1.4071; 95% CI, 1.0171–1.9466) and DSS (P = 0.0238; HR, 1.4342; 95% CI, 1.0507–1.9577). Conclusion Simultaneous mediastinal and abdominal lymph node metastasis is associate with a relatively poor prognosis in pT3 ESCC patients. Disclosure All authors have declared no conflicts of interest.

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Paratracheal lymph node metastasis is associated with cervical lymph node metastasis in patients with thoracic esophageal squamous cell carcinoma

Annals of Surgical Oncology ◽

10.1245/aso.2002.9.1.65 ◽

2002 ◽

Vol 9 (1) ◽

pp. 65-70 ◽

Cited By ~ 16

Author(s):

Fumiaki Sato ◽

Yutaka Shimada ◽

Zhigang Li ◽

Masato Kano ◽

Go Watanabe ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cervical Lymph Node ◽

Cervical Lymph Node Metastasis ◽

Node Metastasis ◽

Paratracheal Lymph Node

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Faculty Opinions recommendation of Incidence of level IIB lymph node metastasis in supraglottic laryngeal squamous cell carcinoma with clinically negative neck--a prospective study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717597858.792952907 ◽

2012 ◽

Author(s):

Giulio Cantu ◽

Stefano Riccio ◽

Sarah Colombo

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Prospective Study ◽

Cell Carcinoma ◽

Squamous Cell ◽

Laryngeal Squamous Cell Carcinoma ◽

Node Metastasis ◽

A Prospective Study

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Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis

International Journal of Cancer ◽

10.1002/ijc.11283 ◽

2003 ◽

Vol 106 (5) ◽

pp. 683-689 ◽

Cited By ~ 105

Author(s):

Masaki Nagata ◽

Hajime Fujita ◽

Hiroko Ida ◽

Hideyuki Hoshina ◽

Tatsuo Inoue ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Microarray Analysis ◽

Squamous Cell ◽

Cdna Microarray Analysis ◽

Node Metastasis ◽

Potential Biomarkers

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A nomogram to predict lymph node metastasis risk for early esophageal squamous cell carcinoma

BMC Cancer ◽

10.1186/s12885-021-08077-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xiaofeng Duan ◽

Xiaobin Shang ◽

Jie Yue ◽

Zhao Ma ◽

Chuangui Chen ◽

...

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Early Stage ◽

Derivation Cohort ◽

Node Metastasis

Abstract Background A nomogram was developed to predict lymph node metastasis (LNM) for patients with early-stage esophageal squamous cell carcinoma (ESCC). Methods We used the clinical data of ESCC patients with pathological T1 stage disease who underwent surgery from January 2011 to June 2018 to develop a nomogram model. Multivariable logistic regression was used to confirm the risk factors for variable selection. The risk of LNM was stratified based on the nomogram model. The nomogram was validated by an independent cohort which included early ESCC patients underwent esophagectomy between July 2018 and December 2019. Results Of the 223 patients, 36 (16.1%) patients had LNM. The following three variables were confirmed as LNM risk factors and were included in the nomogram model: tumor differentiation (odds ratio [OR] = 3.776, 95% confidence interval [CI] 1.515–9.360, p = 0.004), depth of tumor invasion (OR = 3.124, 95% CI 1.146–8.511, p = 0.026), and tumor size (OR = 2.420, 95% CI 1.070–5.473, p = 0.034). The C-index was 0.810 (95% CI 0.742–0.895) in the derivation cohort (223 patients) and 0.830 (95% CI 0.763–0.902) in the validation cohort (80 patients). Conclusions A validated nomogram can predict the risk of LNM via risk stratification. It could be used to assist in the decision-making process to determine which patients should undergo esophagectomy and for which patients with a low risk of LNM, curative endoscopic resection would be sufficient.

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