PS02.225: PROGNOSTIC VALUE OF LYMPH NODE METASTASIS IN DIFFERENT SITES IN PATHOLOGICAL T3 ESOPHAGEAL SQUAMOUS CELL CARCINOMA PATIENTS

Background The aim of this study was to evaluate the impact of different sites of lymph node metastasis in pathological T3 (pT3) esophageal squamous cell carcinoma patients (ESCC). Methods We retrospectively reviewed 300 consecutive ESCC patients who underwent radical minimally invasive esophagectomy (MIE) and two-field lymphadenectomy from 2010 to 2015. After exclusion, 111 cases were analyzed. Patients were divided into 3 groups (mediastinal metastasis, abdominal metastasis, and simultaneous metastasis) according to their lymph node metastatic sites. Disease-free survival (DFS) and disease-specific survival (DSS) were analyzed. Results The results showed that the incidence of lymph node metastasize to mediastinum, abdomen, and simultaneous was 55 (49.5%), 21(18.9%), 35(31.6%), respectively. Patients in simultaneous metastasis group had a higher cancer recurrence (log-rank test; P = 0.0341; Figure 1A) than mediastinum and abdomen metastasis group. Similarly, patients in simultaneous metastasis group had greater rate of cancer-related death (log-rank test; P = 0.0177; Figure 1B) than mediastinum and abdomen metastasis group. In the multivariate model, metastasis site was an independent risk factor in both DFS (P = 0.0402; HR, 1.4071; 95% CI, 1.0171–1.9466) and DSS (P = 0.0238; HR, 1.4342; 95% CI, 1.0507–1.9577). Conclusion Simultaneous mediastinal and abdominal lymph node metastasis is associate with a relatively poor prognosis in pT3 ESCC patients. Disclosure All authors have declared no conflicts of interest.