Long-term natural history of the idiopathic epiretinal membrane in children and young adults

Purpose: To investigate the natural history of idiopathic epiretinal membrane (ERM) in eyes with good visual function using optical coherence tomography (OCT). Methods: Sixty-two eyes of 58 patients with idiopathic ERM, visual acuity of 20/40 or better, and no significant metamorphopsia were included. The best corrected visual acuity (BCVA), central macular thickness (CMT), membrane configuration, and ellipsoid zone signal data over 24 months were retrospectively analyzed. Based on OCT findings, ERM configurations were categorized as global attachment (GA), partial attachment (PA), pseudohole, and vitreomacular traction (VMT). Results: The mean BCVA and CMT did not change significantly between baseline and 24 months. GA, PA, pseudohole, and VMT types were observed in 33, 19, 9, and 1 eye at baseline, and in 20, 22, 10, and 1 eye at 24 months, respectively. A membrane configuration change was noted in 24 eyes (38.7%) during follow-up, and the distribution shifted from GA to the other types (p < 0.001). Six eyes had visual loss due to membrane progression, and 4 eyes had spontaneous membrane separation. Of the 10 eyes with progression or separation, 6 were of the PA type. Conclusions: Although the BCVA remains stable over 2 years in most idiopathic ERM eyes with good visual function at baseline, the membrane configuration may change, affecting visual acuity. The GA type would be an early stage, and the PA type is prone to changes in visual acuity.

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Natural History of Chronic Hepatitis B Infection Among Chinese Children and Young Adults

Journal of Pediatric Gastroenterology and Nutrition ◽

10.1097/mpg.0000000000003106 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Shirley Mo ◽

Loretta Au ◽

Sherry Huang ◽

Preeti Malik ◽

Debra H. Pan

Keyword(s):

Young Adults ◽

Chronic Hepatitis ◽

Natural History ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Chinese Children ◽

Hepatitis B Infection ◽

Chronic Hepatitis B Infection ◽

History Of ◽

Children And Young Adults

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The natural history of pineal cysts in children and young adults

Yearbook of Diagnostic Radiology ◽

10.1016/s0098-1672(10)79221-3 ◽

2010 ◽

Vol 2010 ◽

pp. 332-333

Author(s):

A.G. Osborn

Keyword(s):

Young Adults ◽

Natural History ◽

History Of ◽

Children And Young Adults

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Natural history and imaging prevalence of cavernous malformations in children and young adults

Journal of Neurosurgery Pediatrics ◽

10.3171/2011.11.peds11390 ◽

2012 ◽

Vol 9 (2) ◽

pp. 198-205 ◽

Cited By ~ 79

Author(s):

Wajd N. Al-Holou ◽

Thomas M. O'Lynnger ◽

Aditya S. Pandey ◽

Joseph J. Gemmete ◽

B. Gregory Thompson ◽

...

Keyword(s):

Young Adults ◽

Natural History ◽

Mr Imaging ◽

Group Versus ◽

Cavernous Malformations ◽

Age Related ◽

History Analysis ◽

History Of ◽

Children And Young Adults

Object This study was undertaken to define the age-related prevalence of cavernous malformations (CMs) in children and young adults undergoing intracranial imaging. In addition, the authors aim to clarify the natural history of CMs in young people, especially in those with incidentally discovered lesions. Methods To identify those patients with CMs, the authors retrospectively reviewed the electronic medical records of 14,936 consecutive patients 25 years of age or younger who had undergone brain MR imaging. In patients with a CM, clinical and imaging data were collected. Patients with untreated cavernomas who had more than 6 months of clinical and MR imaging follow-up were included in a natural history analysis. The natural history analysis included 110 CMs in 56 patients with a 3.5-year mean clinical follow-up interval (199 patient-years and 361 cavernoma-years). Results In 92 patients (0.6%), 164 CMs were identified. The imaging prevalence of cavernomas increased with advancing age (p = 0.002). Multiple CMs occurred in 28 patients (30%), and 8 patients (9%) had a family history of multiple CMs. Fifty patients (54%) presented with symptoms related to the cavernoma, of whom 30 presented with hemorrhage (33%). Of the 164 cavernomas identified, 103 (63%) were considered incidental, asymptomatic lesions. Larger size was associated with acute symptomatic presentation (p = 0.0001). During the follow-up interval, 6 patients with 8 cavernomas developed 11 symptomatic hemorrhages after initial identification. Five of the patients who had a hemorrhage during the follow-up interval had initially presented with hemorrhage, while only 1 had presented incidentally. The hemorrhage rate for all patients in the natural history group was 1.6% per patient-year and 0.9% per cavernoma-year. The hemorrhage rate was 8.0% per patient-year in the symptomatic group versus 0.2% in the incidental group. Symptomatic hemorrhage after long-term follow-up was associated with initial acute presentation (p = 0.02). Conclusions The imaging prevalence of CM increases with advancing age during childhood. Patients presenting without hemorrhage have a significantly lower risk of bleeding compared with those who present with acute neurological symptoms. Comparing this series of children to prior analyses of CM natural history in adults, the authors' data do not suggest a higher bleeding risk in younger patients.

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