Long-term Natural History of Dry Eye Disease from the Patient's Perspective

Despite the importance of dry eye disease (DED) treatment, the rate of DED treatment discontinuation, especially discontinuation of ophthalmic follow-up, remains unknown. This study aimed to assess the prevalence and risk factors of ophthalmic follow-up discontinuation for DED. A cross-sectional survey of 1030 participants was conducted using a self-administered web-survey instrument. We collected lifestyle information, history of DED diagnosis, types of treatment, frequency of eye-drop usage, symptoms, and the reasons for discontinuing treatment. Statistical analyses including logistic regression were used to evaluate the risk factors of discontinuing ophthalmic follow-up for DED. A past history of clinical DED diagnosis was reported by 155 (15.0%) subjects. Of those, 130 had persistent DED, and 88 (67.7%) of the subjects reported discontinuation of ophthalmic follow-up for DED. The most prevalent reasons for ophthalmic follow-up discontinuation were time restrictions, followed by dissatisfaction with the DED treatment. Duration after DED diagnosis was the only significant risk factor for discontinuing ophthalmic follow-up after adjusting for age and sex (odds ratio = 1.09, 95% confidence interval = 1.02–1.17, p = 0.009). In conclusion, longer DED duration after diagnosis was a significant risk factor for discontinuing ophthalmic follow-up for DED. This study showed that DED ophthalmic follow-up discontinuation involves both medical and non-medical reasons. Clinicians need to be aware of them, and preventative effort is needed to avoid discontinuation.

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Blood Concentrations of Cyclosporin A During Long-Term Treatment With Cyclosporin A Ophthalmic Emulsions in Patients With Moderate to Severe Dry Eye Disease

Journal of Ocular Pharmacology and Therapeutics ◽

10.1089/10807680260362696 ◽

2002 ◽

Vol 18 (5) ◽

pp. 411-418 ◽

Cited By ~ 37

Author(s):

David S. Small ◽

Andrew Acheampong ◽

Brenda Reis ◽

Katherine Stern ◽

William Stewart ◽

...

Keyword(s):

Cyclosporin A ◽

Dry Eye ◽

Term Treatment ◽

Dry Eye Disease ◽

Eye Disease ◽

Blood Concentrations ◽

Long Term Treatment

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Refractory dry eye disease associated with Meige’s syndrome induced by long-term use of an atypical antipsychotic

BMC Ophthalmology ◽

10.1186/s12886-020-01738-w ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Ji Eun Kim ◽

Ji Won Jung

Keyword(s):

Atypical Antipsychotic ◽

Dry Eye ◽

Dry Eye Disease ◽

Eye Disease ◽

Psychotic Symptoms ◽

Oromandibular Dystonia ◽

Drug Induced ◽

Involuntary Movements ◽

Body Sensation ◽

History Of

Abstract Background We report a case of Meige’s syndrome induced by an atypical antipsychotic (blonanserin) that presented with refractory dry eye disease. Case presentation A 37-year-old woman with a 6-month history of foreign body sensation in the eyes and difficulty in opening her eyes was treated at a local clinic for dry eye disease. Despite this treatment, her symptoms did not improve and she was transferred to our attention. Our assessment revealed involuntary movements of her eyelids accompanied by repetitive pursing of her lips. She had been undergoing treatment with blonanserin for 5 years for schizophrenia. She was diagnosed with drug-induced Meige’s syndrome after a psychiatric and neurological consultation. After a 2-month gradual dose reduction and discontinuing blonanserin, involuntary movements of the eyelids with oromandibular dystonia were resolved. Three months after discontinuing blonanserin, there was no recurrence of symptoms, and she had no exacerbation of psychotic symptoms. Conclusions In patients with refractory dry eye disease, especially those with involuntary movements of the eyelids with oromandibular dystonia, it is important to ask about their psychotropic medications and to consider the possibility of drug-induced Meige’s syndrome and discontinuation of medications, if possible.

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Symptoms of Dry Eye Disease in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19)

Journal of Ophthalmology ◽

10.1155/2021/2678706 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Yan Wang ◽

Sen Yang ◽

Yue Zhang ◽

Xin Zhang ◽

Yaping Jiang ◽

...

Keyword(s):

Dry Eye ◽

Visual Function ◽

Muscle Soreness ◽

Previous History ◽

Dry Eye Disease ◽

Hospitalized Patients ◽

Impact Factors ◽

Eye Disease ◽

Biochemical Tests ◽

History Of

Background. We aimed to investigate the symptoms of the dry eye disease (DED) of hospitalized patients with coronavirus disease 2019 (COVID-19). Methods. This cross-sectional, observational study analysis included 91 hospitalized patients with confirmed COVID-19 in Wuhan, China. The Ocular Surface Disease Index (OSDI) and the five-item Dry Eye Questionnaire (DEQ-5) were used to assess the severity of DED symptoms in the patients, and the analysis of variance was used to determine the factors associated with DED. Results. A total of 42 patients consented to complete the investigation (response rate 46.15%). There were 26 (61.90%) patients who were diagnosed with DED symptoms by OSDI, and there were 28 (66.67%) patients with DED symptoms who were diagnosed by DEQ-5 score. For the biochemical tests, the patients with DED symptoms had lower aspartate aminotransferase (AST) levels compared to those with no DED symptoms (20.86 vs. 42.14, p = 0.04 ). Further analysis showed that a previous history of cardiac or stroke disease ( p = 0.02 ) and typical symptoms of muscle soreness ( p = 0.03 ) were significantly different among the four DED symptoms groups on the basis of OSDI scores. The contributing factors of OSDI were mainly focused on visual function and environmental triggers. Conclusion. The incidence of DED symptoms is higher in hospitalized patients with COVID-19. The serum AST levels, history of cardiac or stroke disease, and the typical symptoms of muscle soreness may be the main impact factors on DED symptoms. We also need to pay more attention to the visual function and environmental triggers of hospitalized patients with COVID-19.

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