scholarly journals Local control of hepatocellular carcinoma and colorectal liver metastases after surgical microwave ablation without concomitant hepatectomy

2021 ◽  
Author(s):  
Luís Filipe Abreu de Carvalho ◽  
Bram Logghe ◽  
Stijn Van Cleven ◽  
Aude Vanlander ◽  
Suzane Moura Ribeiro ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Metastases ◽  
Local Control ◽  
Microwave Ablation ◽  
Colorectal Liver Metastases

scholarly journals 3D Quantitative Ablation Margins for Prediction of Ablation Site Recurrence After Stereotactic Image-Guided Microwave Ablation of Colorectal Liver Metastases: A Multicenter Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Simeon J. S. Ruiter ◽  
Pascale Tinguely ◽  
Iwan Paolucci ◽  
Jennie Engstrand ◽  
Daniel Candinas ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Multicenter Study ◽  
Microwave Ablation ◽  
Colorectal Liver Metastases ◽  
Liver Tumors ◽  
Three Dimensional ◽  
Multivariable Logistic Regression Analysis ◽  
Tumor Diameter ◽  
Ablation Margin ◽  
The Impact

BackgroundThree-dimensional (3D) volumetric ablation margin assessment after thermal ablation of liver tumors using software has been described, but its predictive value on treatment efficacy when accounting for other factors known to correlate ablation site recurrence (ASR) remains unknown.PurposeTo investigate 3D quantitative ablation margins (3D-QAMs) as an algorithm to predict ASR within 1 year after stereotactic microwave ablation (SMWA) for colorectal liver metastases (CRLM).Materials and MethodsSixty-five tumors in 47 patients from a prospective multicenter study of patients undergoing SMWA for CRLM were included in this retrospective 3D-QAM analysis. Using a previously developed algorithm, 3D-QAM defined as the distribution of tumor to ablation surface distances was assessed in co-registered pre- and post-ablation CT scans. The discriminatory power and optimal cutoff values for 3D-QAM were assessed using receiver operating characteristic (ROC) curves. Multivariable logistic regression analysis using generalized estimating equations was applied to investigate the impact of various 3D-QAM outputs on 1-year ASR while accounting for other known influencing factors.ResultsTen of the 65 (15.4%) tumors included for 3D-QAM analysis developed ASR. ROC analyses identified i) 3D-QAM <1 mm for >23% of the tumor surface, ii) 3D-QAM <5 mm for >45%, and iii) the minimal ablation margin (MAM) as the 3D-QAM outputs with optimal discriminatory qualities. The multivariable regression model without 3D-QAM yielded tumor diameter and KRAS mutation as 1-year ASR predictors. When adding 3D-QAM, this factor became the main predictor of 1-year ASR [odds ratio (OR) 21.67 (CI 2.48, 165.21) if defined as >23% <1 mm; OR 0.52 (CI 0.29, 0.95) if defined as MAM].Conclusions3D-QAM allows objectifiable and standardized assessment of tumor coverage by the ablation zone after SMWA. Our data shows that 3D-QAM represents the most important factor predicting ASR within 1 year after SMWA of CRLM.

2502 POSTER Microwave Ablation of Ex Vivo Human Liver and Colorectal Liver Metastases With a Novel 14.5 GHz Generator

2011 ◽  
Vol 47 ◽  
pp. S217-S218
Author(s):  
R. Jones ◽  
D. Dunne ◽  
M. Terlizzo ◽  
S. Fenwick ◽  
H. Malik ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Human Liver ◽  
Microwave Ablation ◽  
Colorectal Liver Metastases ◽  
Ex Vivo

Microwave Ablation (MWA) of Colorectal Liver Metastases: A Single Institution Experience

2010 ◽  
Vol 105 ◽  
pp. S106
Author(s):  
Sharique Nazir ◽  
Kwan Lau ◽  
David Sindram ◽  
John Martinie ◽  
Armand Asarian ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Microwave Ablation ◽  
Colorectal Liver Metastases ◽  
Single Institution

Stereotactic body radiation therapy for local control of liver metastases from colorectal cancer.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 662-662
Author(s):  
Ji Hyeon Joo ◽  
Jong Hoon Kim
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Local Control ◽  
Colorectal Liver Metastases ◽  
Lesion Size ◽  
Dose Fractionation ◽  
Pattern Of Failure ◽  
N Stage ◽  
Hepatic Lesions ◽  
Significant Factors

662 Background: Although possible candidates for surgical treatment are increasing, majority of colorectal cancer patients with liver metastases are ineligible for surgery. In our institution, SBRT for liver metastatic colorectal carcinoma has been adopted since 2005. By reviewing the treatment outcomes of relatively large cohorts treated with homogeneous technique, we aimed to report patterns of recurrence and the most effective dose fractionation schedule. Methods: Seventy patients with colorectal liver metastases were treated with SBRT from 2005 to 2014. Total number of treated lesions was 103. Median tumor size was 2.5 cm, with ≥ 3 cm in 42 (41%) lesions. Prescribed doses were biologically equivalent dose (BED) ≥ 112 Gy10, but, if small bowel is adjacent to target volume, dose was decreased according to the normal tissue tolerance dose. Prescription doses relevant to BED ≥ 112 Gy10 were ≥ 45 Gy in 3 fractions or ≥ 60 Gy in 5 fractions, in this study. Results: Median follow-up period was 34.2 months (range, 5.3-121.8). The 2-year local control rate was 92% when full prescription dose was delivered, and 73% if compromised dose group was included. On prognostic factor analysis for local control, N-stage (P= 0.008), and BED (P= 0.001) were significant factors. Overall survival rate was 86% for BED ≥ 112 Gy10 group, and 73% for total cohort. The major pattern of failure was out-of-field intrahepatic progression. On multivariate analysis, N stage (P= 0.001), lesion size (P= 0.010) and number of treated hepatic lesions (P< 0.001) were significant factors for intrahepatic control. Conclusions: Liver SBRT was an effective treatment option for colorectal liver metastases. If BED ≥ 112 Gy10 was delivered, we could expect long-term survival in substantial portion of patients. Major pattern of failure was out-of-field intrahepatic progression, which was related to number of treated hepatic lesions, lesion size and N-stage.

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