BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas

2004 ◽  
Vol 444 (6) ◽  
Author(s):  
Paula Soares ◽  
V�tor Trovisco ◽  
AnaSofia Rocha ◽  
T�lia Feij�o ◽  
AnaPaula Rebocho ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Braf Mutations ◽  
Poorly Differentiated

Aggressive cribriform-morular variant of papillary thyroid carcinoma: Report of an unusual case with pulmonary metastasis displaying poorly differentiated features

2018 ◽  
Vol 68 (12) ◽  
pp. 700-705 ◽  
Author(s):  
Hiromi Tsuji ◽  
Hironao Yasuoka ◽  
Yasushi Nakamura ◽  
Mitsuyoshi Hirokawa ◽  
Takashi Hiroshima ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Pulmonary Metastasis ◽  
Unusual Case ◽  
Papillary Thyroid ◽  
Poorly Differentiated ◽  
Cribriform Morular Variant

scholarly journals BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (Review)

2012 ◽  
Vol 6 (4) ◽  
pp. 687-694 ◽  
Author(s):  
GIULIA COSTANZA LEONARDI ◽  
SAVERIO CANDIDO ◽  
MAURIZIO CARBONE ◽  
FABIO RAITI ◽  
VALERIA COLAIANNI ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Targeted Therapies ◽  
Papillary Thyroid ◽  
Braf Mutations

Coexistence of TERT Promoter and BRAF Mutations in Papillary Thyroid Carcinoma: Added Value in Patient Prognosis?

2015 ◽  
Vol 33 (6) ◽  
pp. 667-668 ◽  
Author(s):  
Miguel Melo ◽  
Adriana Gaspar da Rocha ◽  
João Vinagre ◽  
Manuel Sobrinho-Simões ◽  
Paula Soares
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Added Value ◽  
Papillary Thyroid ◽  
Braf Mutations ◽  
Tert Promoter ◽  
Patient Prognosis

scholarly journals Internal Spreading of Papillary Thyroid Carcinoma: A Case Report and Systemic Review

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Hui Jin ◽  
Huanhuan Yan ◽  
Huamei Tang ◽  
Miao Zheng ◽  
Chaojie Wu ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Frozen Section ◽  
Large Diameter ◽  
Systemic Review ◽  
Papillary Thyroid ◽  
Intraoperative Frozen Section ◽  
Central Lesion ◽  
Preoperative Ct ◽  
Poorly Differentiated

An 18-year-old female diagnosed finally as PTC with intrathyroid spread was reported, and the diagnosis and surgical treatment of internal spreading of PTC were discussed. One lump was found on the thyroid isthmus by physical examination and B ultrasound, and multiple nodular shadows were found by CT. This patient finally underwent total thyroidectomy with bilateral central node dissection due to multifocal papillary thyroid carcinoma except PTC in the isthmus found in right lobe by intraoperative frozen section. The pathological section showed a major thyroid carcinoma in thyroid isthmus with scattered micropapillary carcinoma around it in the whole thyroid gland. The small lesions are distributed around central lesion in a radial form and the number of small lesions decreases with increased distance from central lesion. PTC with internal spread should be distinguished from multifocal PTC and poorly differentiated PTC in pathology. Thyroid cancerous node had a large diameter; it was likely to have internal spread. Combined imaging before surgery should be valued to diagnose PTC with internal spread. Preoperative CT and intraoperative frozen section are helpful for surgical volume selection of PTC with internal spread.

Case of aggressive metastatic follicular variant papillary thyroid carcinoma with BRAF K601E and BCORL1 mutations

2020 ◽  
Vol 13 (6) ◽  
pp. e234208
Author(s):  
Doaa Attia ◽  
Alexander Lurie ◽  
Qihui Zhai ◽  
Robert Smallridge
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Left Lobe ◽  
Papillary Thyroid ◽  
Braf Mutations ◽  
Follicular Variant ◽  
Positron Emission ◽  
Small Defect ◽  
Tumour Biopsy ◽  
The Right

BCL6 corepressor like-1 (BCORL1) mutation has rarely been described in thyroid cancer or in association with BRAF mutations in any malignancy. However, we report a 49-year-old woman who had aggressive follicular variant papillary thyroid carcinoma (FV-PTC) with both the BRAF K601E and BCORL1 mutations. The patient underwent a total thyroidectomy for a 3.6 cm right thyroid nodule and a smaller lesion in the left lobe in 2007; both were FV-PTCs with no lymphovascular invasion or metastases. In 2015, a positron emission tomography–CT scan showed a small defect in the left posterior lateral fifth rib with mild increased hypermetabolic activity with standardised uptake value of 3.9 and another lesion in the right hip at the junction of the femoral neck and trochanter. Tumour biopsy and genetic analysis revealed an uncommon BRAF K601E and a rare BCORL1 mutation. While rare, we report a case of aggressive FV-PTC with both the BRAF K601E and BCORL1 mutations.

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