BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas

An 18-year-old female diagnosed finally as PTC with intrathyroid spread was reported, and the diagnosis and surgical treatment of internal spreading of PTC were discussed. One lump was found on the thyroid isthmus by physical examination and B ultrasound, and multiple nodular shadows were found by CT. This patient finally underwent total thyroidectomy with bilateral central node dissection due to multifocal papillary thyroid carcinoma except PTC in the isthmus found in right lobe by intraoperative frozen section. The pathological section showed a major thyroid carcinoma in thyroid isthmus with scattered micropapillary carcinoma around it in the whole thyroid gland. The small lesions are distributed around central lesion in a radial form and the number of small lesions decreases with increased distance from central lesion. PTC with internal spread should be distinguished from multifocal PTC and poorly differentiated PTC in pathology. Thyroid cancerous node had a large diameter; it was likely to have internal spread. Combined imaging before surgery should be valued to diagnose PTC with internal spread. Preoperative CT and intraoperative frozen section are helpful for surgical volume selection of PTC with internal spread.

Download Full-text

In the Basis of Hashimoto’s Thyroiditis, to Form Papillary Thyroid Carcinoma, Metastasized and Then to De-Differentiate into Poorly Differentiated Squamous Cell Carcinoma

Journal of Cancer Therapy ◽

10.4236/jct.2021.125024 ◽

2021 ◽

Vol 12 (05) ◽

pp. 254-267

Author(s):

Xinle Ren ◽

Di Zhu ◽

Hen Wang ◽

Jilin Wang ◽

Biyun Lin ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Hashimoto’S Thyroiditis ◽

Hashimoto's Thyroiditis ◽

Papillary Thyroid ◽

Poorly Differentiated

Download Full-text

Clinical Features and Prognostic Factors for Survival in Patients with Poorly Differentiated Thyroid Carcinoma and Comparison to the Patients with the Aggressive Variants of Papillary Thyroid Carcinoma

Endocrine Journal ◽

10.1507/endocrj.k06-166 ◽

2007 ◽

Vol 54 (2) ◽

pp. 265-274 ◽

Cited By ~ 66

Author(s):

Tae Sik JUNG ◽

Tae Yong KIM ◽

Kyung Won KIM ◽

Young Lyun OH ◽

Do Joon PARK ◽

...

Keyword(s):

Prognostic Factors ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Clinical Features ◽

Differentiated Thyroid Carcinoma ◽

Papillary Thyroid ◽

Poorly Differentiated Thyroid Carcinoma ◽

Poorly Differentiated

Download Full-text

Case of aggressive metastatic follicular variant papillary thyroid carcinoma with BRAF K601E and BCORL1 mutations

BMJ Case Reports ◽

10.1136/bcr-2019-234208 ◽

2020 ◽

Vol 13 (6) ◽

pp. e234208

Author(s):

Doaa Attia ◽

Alexander Lurie ◽

Qihui Zhai ◽

Robert Smallridge

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Left Lobe ◽

Papillary Thyroid ◽

Braf Mutations ◽

Follicular Variant ◽

Positron Emission ◽

Small Defect ◽

Tumour Biopsy ◽

The Right

BCL6 corepressor like-1 (BCORL1) mutation has rarely been described in thyroid cancer or in association with BRAF mutations in any malignancy. However, we report a 49-year-old woman who had aggressive follicular variant papillary thyroid carcinoma (FV-PTC) with both the BRAF K601E and BCORL1 mutations. The patient underwent a total thyroidectomy for a 3.6 cm right thyroid nodule and a smaller lesion in the left lobe in 2007; both were FV-PTCs with no lymphovascular invasion or metastases. In 2015, a positron emission tomography–CT scan showed a small defect in the left posterior lateral fifth rib with mild increased hypermetabolic activity with standardised uptake value of 3.9 and another lesion in the right hip at the junction of the femoral neck and trochanter. Tumour biopsy and genetic analysis revealed an uncommon BRAF K601E and a rare BCORL1 mutation. While rare, we report a case of aggressive FV-PTC with both the BRAF K601E and BCORL1 mutations.

Download Full-text