Association between height and weight catch-up growth with insulin resistance in pre-pubertal Chinese children born small for gestational age at two different ages

2010 ◽  
Vol 170 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Hong-Zhu Deng ◽  
Yan-Hong Li ◽  
Zhe Su ◽  
Hua-Mei Ma ◽  
Yue-Fang Huang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Chinese Children ◽  
Different Ages ◽  
Catch Up

Insulin resistance and its association with catch-up growth in Chinese children born small for gestational age

Obesity ◽  
2016 ◽  
Vol 25 (1) ◽  
pp. 172-177 ◽  
Author(s):  
Chunhua Liu ◽  
Baiyan Wu ◽  
Niyang Lin ◽  
Xiaoyi Fang
Keyword(s):  
Insulin Resistance ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Chinese Children ◽  
Catch Up

scholarly journals Premature small for gestational age infants fed an exclusive human milk-based diet achieve catch-up growth without metabolic consequences at 2 years of age

2018 ◽  
Vol 104 (3) ◽  
pp. F242-F247 ◽  
Author(s):  
Chonnikant Visuthranukul ◽  
Steven A Abrams ◽  
Keli M Hawthorne ◽  
Joseph L Hagan ◽  
Amy B Hair
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Birth Weight ◽  
Human Milk ◽  
Premature Infants ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Insulin Level ◽  
Metabolic Outcomes ◽  
Catch Up

ObjectiveTo compare postdischarge growth, adiposity and metabolic outcomes of appropriate for gestational age (AGA) versus small for gestational age (SGA) premature infants fed an exclusive human milk (HM)-based diet in the neonatal intensive care unit.DesignPremature infants (birth weight ≤1250 g) fed an exclusive HM-based diet were examined at 12–15 months corrected gestational age (CGA) (visit 1) for anthropometrics, serum glucose and non-fasting insulin, and at 18–22 months CGA (visit 2) for body composition by dual-energy X-ray absorptiometry.ResultsOf 51 children, 33 were AGA and 18 were SGA at birth. The SGA group had weight gain (g/day) equal to AGA group during the follow-up period. SGA had a significantly greater body mass index (BMI) z-score gain from visit 1 to visit 2 (0.25±1.10 vs −0.21±0.84, p=0.02) reflecting catch-up growth. There were no significant differences in total fat mass (FM) and trunk FM between groups. SGA had significantly lower insulin level (5.0±3.7 vs 17.3±15.1 µU/mL, p=0.02) and homeostatic model of assessment-insulin resistance (1.1±0.9 vs 4.3±4.1, p=0.02). Although regional trunk FM correlated with insulin levels in SGA (r=0.893, p=0.04), they had lower insulin level compared with AGA and no difference in adiposity.ConclusionsSGA premature infants who received an exclusive HM-based diet exhibited greater catch-up growth without increased adiposity or elevated insulin resistance compared with AGA at 2 years of age. An exclusive HM-based diet may improve long-term body composition and metabolic outcomes of premature infants with ≤1250 g birth weight, specifically SGA.

Effects of a High-Protein Diet on Insulin Resistance and Body Fat in Catch-Up Growth Rats Born Small for Gestational Age

2012 ◽  
Vol 78 (3) ◽  
pp. 180-187 ◽  
Author(s):  
Hong-Zhu Deng ◽  
Hong Deng ◽  
Yan-Hong Li ◽  
Zhe Su ◽  
Hua-Mei Ma ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Fat ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Catch Up

scholarly journals Serum adiponectin levels, insulin resistance, and lipid profile in children born small for gestational age are affected by the severity of growth retardation at birth

2007 ◽  
Vol 156 (2) ◽  
pp. 271-277 ◽  
Author(s):  
Eleni N Evagelidou ◽  
Vasileios I Giapros ◽  
Anna S Challa ◽  
Dimitrios N Kiortsis ◽  
Agathocles A Tsatsoulis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Profile ◽  
Gestational Age ◽  
Growth Retardation ◽  
Small For Gestational Age ◽  
Density Lipoprotein ◽  
Model Assessment ◽  
Apo B ◽  
Significant Difference ◽  
Catch Up

Objective: Insulin resistance has been linked to intrauterine growth retardation (IUGR); adiponectin is a protein with insulin-sensitizing properties. This study was designed to test whether being born small for gestational age (SGA) has an effect on blood levels of adiponectin and leptin, insulin resistance parameters, and lipid profile in pre-puberty, taking into consideration the severity of IUGR. Methods: Serum levels of adiponectin, leptin, total cholesterol (t-CHOL), high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, triglycerides, apolipoproteins A-1 (Apo A-1), Apo B and Apo E, lipoprotein(a) (Lp(a)), fasting glucose, and insulin (Ins), the homeostasis model assessment insulin resistance index (HOMA-IR) and anthropometric indices were evaluated in 70 children aged 6–8 years, born appropriate for gestational age (AGA; n = 35) and SGA (n = 35), matched for age, gender, height, and BMI. SGA children were divided into two subgroups according to the severity of IUGR: SGA<3rd percentile (n = 20), and SGA 3rd–10th percentile (n = 15). They were also subdivided in two subgroups, those with (n = 25) and those without (n = 10) catch-up growth, considering their actual height corrected for mid-parental height. Results: SGA children had higher Ins and HOMA-IR than AGA children (Ins, 42 ± 23 vs 32 ± 11 pmol/l; HOMA-IR, 1.30 ± 0.8 vs 0.92 ± 0.3; P<0.05). No significant difference in serum leptin was found between the SGA and the AGA groups but adiponectin showed a trend to be higher in SGA children (13.6 ± 5.7 vs 10.8 ± 5.9 μg/ml respectively). SGA children without catch-up growth had higher adiponectin (15.6 ± 8.5 μg/ml, P<0.05) than AGA children. Among the SGA children, the subgroup <3rd percentile had higher Lp(a) than the subgroup 3rd–10th percentile (P<0.05). An independent positive correlation between adiponectin and Lp(a) was observed in SGA children (R = 0.59, P<0.01). Conclusion: SGA children, although more insulin resistant, had similar or higher adiponectin levels than matched AGA children in pre-puberty. The severity of IUGR appears to affect their metabolic profile during childhood.

Insulin Responses During Catch-up Growth of Infants Who Were Small for Gestational Age

PEDIATRICS ◽  
1976 ◽  
Vol 57 (3) ◽  
pp. 363-371
Author(s):  
Eleanor Colle ◽  
David Schiff ◽  
Gail Andrew ◽  
Charles B. Bauer ◽  
Pamela Fitzhardinge
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Growth Velocity ◽  
Insulin Response ◽  
Growth Characteristics ◽  
Term Infants ◽  
The Mean ◽  
Catch Up ◽  
Insulin Responses ◽  
Permissive Role

Growth characteristics of 15 full-term infants, selected because of weights more than 2 SD below the mean for gestational age, are described. The response to an intravenous injection of glucose was utilized to measure the insulin response of the infants at 6 months. Infants small for gestational age grow at a faster rate than appropriate-for-age infants during the first six months of life. There was a positive correlation between the growth velocity of the period and insulin release and a negative correlation between growth velocity and birth length. There was no correlation between these variables and increases in weight during the same period. Growth velocity during catch-up growth is related to the degree of preceding retardation but insulin may play a permissive role.

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