Head and neck cancer in Germany: a site-specific analysis of survival of the Thuringian cancer registration database

Purpose: In this study, we created site specific Hounsfield Unit (HU) and Relative electron density(RED) calibration curves for computed tomography(CT) and cone beam computed tomography (CBCT) for head and neck radiotherapy dose calculation and compared them with standard calibration curves. Methods: The calibration curves between HU and RED were generated using RANDO phantom for CT and CBCT and fed in the treatment planning system for dose calculation for head and neck patients.The treatment plans for 10 head and neck cancer patients were calculated using the standard calibration curves generated with CATPHAN and head and neck calibration curves generated with RANDO phantom for both CT and CBCT. Dose accuracy of head and neck calibration curves(H/N CC) were compared to the standard calibration curves (SCC) using dose volume metrics and 3D gamma analysis. Results: The results show that slightly better dosimetric agreement from the SCC can be obtained when using this H/N CC. Conclusions: A site specific calibration curves have been proposed and tested for the head-and-neck patients and the results explain the dosimetric benefits.

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Influence of allelism at GSTM1, GSTM3 and GSTP1 gene loci and enzyme expression on site-specific susceptibility to head and neck cancer

European Journal of Cancer ◽

10.1016/s0959-8049(97)85481-0 ◽

1997 ◽

Vol 33 ◽

pp. S183

Author(s):

C. Matthias ◽

V. Jahnke ◽

P. Hand ◽

A.A. Fryer ◽

R.C. Strange

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Enzyme Expression ◽

Site Specific ◽

Gstp1 Gene ◽

Specific Susceptibility

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Risk of Second Primary Malignancy After Esophagectomy for Squamous Cell Carcinoma of the Thoracic Esophagus

Journal of Clinical Oncology ◽

10.1200/jco.2003.12.074 ◽

2003 ◽

Vol 21 (23) ◽

pp. 4336-4341 ◽

Cited By ~ 75

Author(s):

Toshiki Matsubara ◽

Kazuhiko Yamada ◽

Aya Nakagawa

Keyword(s):

Squamous Cell Carcinoma ◽

Head And Neck Cancer ◽

Early Detection ◽

Cell Carcinoma ◽

Head And Neck ◽

Neck Cancer ◽

Squamous Cell ◽

Cancer Registration ◽

Thoracic Esophagus ◽

Second Malignancy

Purpose: To assess the risk of subsequent malignancies after esophagectomy for squamous cell carcinoma of the thoracic esophagus for the establishment of an adequate follow-up program.Patients and Methods: We statistically analyzed clinical factors in 114 cases of second malignancy after esophagectomy that developed in 94 of 679 patients who underwent curative resection. The cancer incidence rates in the general population estimated by the Research Group for Population-Based Cancer Registration in Japan were used as standards for comparison.Results: The 10-year cumulative risk of second malignancy was 34.5%, and the overall relative risk (RR) was 2.98 (95% CI, 2.41 to 3.65). The risk of head and neck cancer was markedly elevated (RR, 34.9; 95% CI, 24.3 to 48.6), followed by the risks of lung cancer (RR, 3.24; 95% CI, 1.89 to 5.19) and stomach cancer (RR, 2.00; 95% CI, 1.17 to 3.21). Multifactor analysis demonstrated that independent factors affecting the risk of subsequent malignancies were presence of other malignancies detected before esophagectomy and any of the following factors: masculine sex, alcohol consumption, and smoking. The 5-year survival rate after detection of subsequent malignancy was 45%. The outcome in patients with subsequent head and neck cancer was significantly less favorable as a result of difficulty in early detection.Conclusion: Patients had a remarkably high risk of subsequent cancer of the upper aerodigestive tract after esophagectomy, in particular, head and neck cancer. Minute postoperative surveillance is strongly recommended, especially in patients with a history of malignancies before esophagectomy. Early detection of second malignancies allowed less invasive treatment with favorable outcome.

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