Loss of GDF-15 abolishes Sulindac chemoprevention in the ApcMin/+ mouse model of intestinal cancer

2009 ◽  
Vol 136 (4) ◽  
pp. 571-576 ◽  
Author(s):  
Teresa A. Zimmers ◽  
Juan C. Gutierrez ◽  
Leonidas G. Koniaris
Keyword(s):  
Mouse Model ◽  
Intestinal Cancer

Conditional expression of fascin increases tumor progression in a mouse model of intestinal cancer

2014 ◽  
Vol 93 (10-12) ◽  
pp. 388-395 ◽  
Author(s):  
Marie Schoumacher ◽  
Fatima El-Marjou ◽  
Marick Laé ◽  
Nadège Kambou ◽  
Daniel Louvard ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Progression ◽  
Intestinal Cancer ◽  
Conditional Expression

scholarly journals Epigenetic modulation of the retinoid X receptor α by green tea in the azoxymethane-ApcMin/+mouse model of intestinal cancer

2009 ◽  
Vol 48 (10) ◽  
pp. 920-933 ◽  
Author(s):  
Suresh R. Volate ◽  
Stephanie J. Muga ◽  
Ala Y. Issa ◽  
Daniela Nitcheva ◽  
Theresa Smith ◽  
...  
Keyword(s):  
Mouse Model ◽  
Green Tea ◽  
Retinoid X Receptor ◽  
Intestinal Cancer ◽  
Epigenetic Modulation

scholarly journals Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer

Oncogene ◽  
2013 ◽  
Vol 33 (28) ◽  
pp. 3742-3747 ◽  
Author(s):  
M A Maynard ◽  
R Ferretti ◽  
K I Hilgendorf ◽  
C Perret ◽  
P Whyte ◽  
...  
Keyword(s):  
Mouse Model ◽  
Intestinal Cancer

scholarly journals SIDT2 RNA transporter promotes lung and gastrointestinal tumor development

2019 ◽  
Author(s):  
Tan A Nguyen ◽  
Kathryn T Bieging-Rolett ◽  
Tracy L Putoczki ◽  
Ian P Wicks ◽  
Laura D Attardi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Lung Adenocarcinoma ◽  
Transmembrane Protein ◽  
Tumor Development ◽  
Intestinal Cancer ◽  
Gastrointestinal Tumor ◽  
Double Stranded Rna ◽  
Selective Autophagy ◽  
Transcriptional Target

SUMMARYRNautophagy is a newly-described type of selective autophagy whereby cellular RNAs are transported into lysosomes for degradation. This process involves the transmembrane protein SIDT2, which transports double-stranded RNA (dsRNA) across the endolysosomal membrane. We previously demonstrated that SIDT2 is a transcriptional target ofp53, but its role in tumorigenesis – if any - is unclear. Unexpectedly, we show here thatSidt2−/−mice with concurrent oncogenicKrasG12Dactivation develop significantly fewer tumors than littermate controls in a mouse model of lung adenocarcinoma (LUAD). Consistent with this observation, loss of SIDT2 also leads to enhanced survival and delayed tumor development in anApcmin/+mouse model of intestinal cancer. Within the intestine,Apcmin/+;Sidt2−/−mice display accumulation of dsRNA in association with increased phosphorylation of eIF2α and JNK as well as elevated rates of apoptosis. Taken together, our data demonstrate a role for SIDT2 - and by extension RNautophagy - in promoting tumor development.

Cardiac Enlargement in a Mouse Model of Intestinal Cancer

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S179
Author(s):  
Julie M. Clements ◽  
Raymond W. Thompson ◽  
Emerson F. Gower ◽  
Kristen A. Mehl ◽  
James A. Carson
Keyword(s):  
Mouse Model ◽  
Intestinal Cancer ◽  
Cardiac Enlargement

Fabrication of novel combinatorial drug encapsulated micelles for enhanced tumor targeting in intestinal cancer in mouse model

2019 ◽  
Vol 234 (9) ◽  
pp. 15450-15458
Author(s):  
Haixiang Yu ◽  
Chunpeng Zhang ◽  
Kai Zhang ◽  
Yangyang Zhou ◽  
Chunsheng Li
Keyword(s):  
Mouse Model ◽  
Tumor Targeting ◽  
Intestinal Cancer
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