Whole-exome sequencing identifies key mutated genes in T790M wildtype/cMET-unamplified lung adenocarcinoma with acquired resistance to first-generation EGFR tyrosine kinase inhibitors

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-018-2634-4 ◽

2018 ◽

Vol 144 (6) ◽

pp. 1079-1086 ◽

Author(s):

Chenguang Li ◽

Hailin Liu ◽

Bin Zhang ◽

Liqun Gong ◽

Yanjun Su ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Exome Sequencing ◽

Tyrosine Kinase Inhibitors ◽

Whole Exome Sequencing ◽

First Generation ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Whole Exome ◽

Egfr Tyrosine Kinase Inhibitors

Download Full-text

EGFR T790M detection and osimertinib treatment response evaluation by liquid biopsy in lung adenocarcinoma patients with acquired resistance to first generation EGFR tyrosine kinase inhibitors

Diagnostic Pathology ◽

10.1186/s13000-018-0728-6 ◽

2018 ◽

Vol 13 (1) ◽

Author(s):

Chenguang Li ◽

Rui Jia ◽

Hailin Liu ◽

Bin Zhang ◽

Changli Wang

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Liquid Biopsy ◽

First Generation ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Response Evaluation ◽

Treatment Response Evaluation ◽

Egfr Tyrosine Kinase Inhibitors ◽

Download Full-text

Abstract 742: Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors

10.1158/1538-7445.am2015-742 ◽

2015 ◽

Author(s):

Yuho Maki ◽

Shinsuke Hashida ◽

Hiromasa Yamamoto ◽

Kazuhiko Shien ◽

Tomoaki Ohtsuka ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Hsp90 Inhibitor ◽

Adenocarcinoma Cell ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

Download Full-text

An activation of LC3A-mediated autophagy contributes tode novoand acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma

The Journal of Pathology ◽

10.1002/path.4354 ◽

2014 ◽

pp. n/a-n/a ◽

Author(s):

Kaito Nihira ◽

Yasuhiro Miki ◽

Shinya Iida ◽

Sodai Narumi ◽

Katsuhiko Ono ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

Download Full-text

Acquired Resistance to EGFR Tyrosine Kinase Inhibitors is Associated With Low Efficacy of Radiation Therapy for Brain Metastases From EGFR-mutant Lung Adenocarcinoma

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2012.07.166 ◽

2012 ◽

Vol 84 (3) ◽

pp. S102

Author(s):

H. Hirata ◽

K. Nakamura ◽

N. Kunitake ◽

Y. Shioyama ◽

T. Sasaki ◽

...

Keyword(s):

Radiation Therapy ◽

Brain Metastases ◽

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Download Full-text

A case of EGFR mutant lung adenocarcinoma that acquired resistance to EGFR-tyrosine kinase inhibitors with MET amplification and epithelial-to-mesenchymal transition

OncoTargets and Therapy ◽

10.2147/ott.s78911 ◽

2015 ◽

pp. 783 ◽

Author(s):

Seigo Miyoshi ◽

Takahide Kato ◽

Hitoshi Katayama ◽

Ryoji Ito ◽

Takafumi Okura ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Tyrosine Kinase Inhibitors ◽

Epithelial To Mesenchymal Transition ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Mesenchymal Transition ◽

Met Amplification ◽

Egfr Tyrosine Kinase Inhibitors ◽

Download Full-text

High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma

10.18632/oncotarget.19777 ◽

2017 ◽

Vol 8 (35) ◽

pp. 59000-59007 ◽

Author(s):

Youyou Xie ◽

Dongqing Lv ◽

Wei Wang ◽

Minhua Ye ◽

Xiaofeng Chen ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Expression Levels ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

Download Full-text

Acquired resistance of lung adenocarcinoma to EGFR-tyrosine kinase inhibitors gefitinib and erlotinib

Cancer Biology & Therapy ◽

10.4161/cbt.9.8.11881 ◽

2010 ◽

Vol 9 (8) ◽

pp. 572-582 ◽

Author(s):

Yan Xu ◽

Hongyu Liu ◽

Jun Chen ◽

Qinghua Zhou

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

Download Full-text

P1.02-050 Acquired Resistance to EGFR Tyrosine Kinase Inhibitors (TKIs) in EGFR-Mutant Lung Adenocarcinoma among Hispanics (Rbiop-CLICaP)

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2016.11.634 ◽

2017 ◽

Vol 12 (1) ◽

pp. S517-S518

Author(s):

Andrés Cardona ◽

Oscar Arrieta ◽

Leonardo Rojas ◽

Beatriz Wills ◽

Noemi Reguart ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Download Full-text

P76.85 Afatinib and Necitumumab in EGFR mutant NSCLC with Acquired Resistance to 1st or 3rd Generation EGFR Tyrosine Kinase Inhibitors

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2021.01.1142 ◽

2021 ◽

Vol 16 (3) ◽

pp. S626

Author(s):

S. Padda ◽

J. Whisenant ◽

J. Neal ◽

S. York ◽

W. Iams ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Download Full-text

Reversion of mesenchymal behaviour by AZD9291 (osimertinib) in EGFR mutant NSCLC cell lines resistant to first generation EGFR tyrosine kinase inhibitors

Annals of Oncology ◽

10.1093/annonc/mdw362.12 ◽

2016 ◽

Vol 27 ◽

pp. vi3

Author(s):

B. Savastano ◽

C.M. Della Corte ◽

F. Papaccio ◽

V. Giuseppe ◽

G. Esposito ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

First Generation ◽

Kinase Inhibitors ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Download Full-text