IgG antibody response to ES or somatic antigens of Dicrocoelium dendriticum (Trematoda) in experimentally infected sheep

2000 ◽  
Vol 86 (6) ◽  
pp. 472-479 ◽  
Author(s):  
C. González-Lanza ◽  
M. Y. Manga-González ◽  
R. Campo ◽  
P. Del-Pozo ◽  
H. Sandoval ◽  
...  
Keyword(s):  
Antibody Response ◽  
Infected Sheep ◽  
Igg Antibody ◽  
Dicrocoelium Dendriticum ◽  
Somatic Antigens

scholarly journals Evaluation of Antibody Response to Various Developmental Stage Specific Somatic Antigens ofParamphistomum epiclitumin Goats

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Jyoti ◽  
A. Prasad ◽  
Nirbhay Kumar Singh
Keyword(s):  
Early Diagnosis ◽  
Antibody Response ◽  
Developmental Stage ◽  
Statistical Significance ◽  
Polyacrylamide Gel Electrophoresis ◽  
Electrophoretic Analysis ◽  
Igg Antibody ◽  
Native Polyacrylamide Gel Electrophoresis ◽  
Paramphistomum Epiclitum ◽  
Somatic Antigens

Electrophoretic analysis of various developmental stage specific somatic antigens ofParamphistomum epiclitum(Digenea: Paramphistomidae), namely, metacercariae (McAg), immature intestinal flukes (ImIAg), immature ruminal flukes (ImRAg), and adult flukes (AAg), was done by native polyacrylamide gel electrophoresis. Result revealed presence of 3 (range 15.2–40.3 kDa), 13 (9.3–121.2 kDa), 14 (9.3–169.3 kDa), and 15 (8.0–169.3 kDa) polypeptides in McAg, ImIAg, ImRAg, and AAg, respectively. With an aim to identify a suitable immunodiagnostic antigen for early diagnosis of amphistomosis, the IgG antibody response to various developmental stage antigens in goats experimentally infected with metacercariae ofP. epiclitumwas evaluated by ELISA. The highest OD values were recorded with ImIAg which ranged between 0.23 and 0.55 with a significant increase from the 2nd week till 8th week of infection with a peak at 6th week. The analysis of statistical significance using a one-way analysis of variance with multiple pair wise comparisons revealed that IgG response was significantly higher with all antigens (P<0.01) except McAg (P>0.05) with a maximum mean difference of 0.1838 in comparison to control with ImIAg, thus, indicating that ImIAg which could be further exploited for its potential is a candidate for immunodiagnostic antigen for early diagnosis of amphistomosis.

scholarly journals Trichinella britovihuman infection in Spain : antibody response to surface, excretory/secretory and somatic antigens

Parasite ◽  
2003 ◽  
Vol 10 (2) ◽  
pp. 159-164 ◽  
Author(s):  
M. Rodríguez-Osorio ◽  
V. Gómez-Garcia ◽  
R. Benito ◽  
J. Gil
Keyword(s):  
Antibody Response ◽  
Somatic Antigens

scholarly journals Prior COVID-19 Infection and Antibody Response to Single Versus Double Dose mRNA SARS-CoV-2 Vaccination

2021 ◽  
Author(s):  
Joseph E. Ebinger ◽  
Justyna Fert-Bober ◽  
Ignat Printsev ◽  
Min Wu ◽  
Nancy Sun ◽  
...  
Keyword(s):  
Antibody Response ◽  
Dose Regimen ◽  
Vaccine Dose ◽  
Double Dose ◽  
Igg Antibody ◽  
Vaccination Programs ◽  
Public Health Programs ◽  
Supply Chain Logistics ◽  
Potential Efficacy ◽  
Single Versus

The double dose regimen for mRNA vaccines against SARS-CoV-2 presents both a hope and a challenge for global efforts to curb the COVID-19 pandemic. With supply chain logistics impacting the rollout of population-scale vaccination programs, increasing attention has turned to the potential efficacy of single versus double dose vaccine administration for select individuals. To this end, we examined response to Pfizer-BioNTech mRNA vaccine in a large cohort of healthcare workers including those with versus without prior COVID-19 infection. For all participants, we quantified circulating levels of SARS-CoV-2 anti-spike (S) protein IgG at baseline prior to vaccine, after vaccine dose 1, and after vaccine dose 2. We observed that the anti-S IgG antibody response following a single vaccine dose in persons who had recovered from confirmed prior COVID-19 infection was similar to the antibody response following two doses of vaccine in persons without prior infection (P>0.57). Patterns were similar for the post-vaccine symptoms experienced by infection recovered persons following their first dose compared to the symptoms experienced by infection naive persons following their second dose (P=0.66). These results support the premise that a single dose of mRNA vaccine could provoke in COVID-19 recovered individuals a level of immunity that is comparable to that seen in infection naive persons following a double dose regimen. Additional studies are needed to validate our findings, which could allow for public health programs to expand the reach of population wide vaccination efforts.

scholarly journals Influence of HLA-DRB1 and HLA-DQB1 Alleles on IgG Antibody Response to the P. vivax MSP-1, MSP-3α and MSP-9 in Individuals from Brazilian Endemic Area

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e36419 ◽  
Author(s):  
Josué C. Lima-Junior ◽  
Rodrigo N. Rodrigues-da-Silva ◽  
Dalma M. Banic ◽  
Jianlin Jiang ◽  
Balwan Singh ◽  
...  
Keyword(s):  
Antibody Response ◽  
Endemic Area ◽  
Igg Antibody

scholarly journals IgG antibody response against Plasmodium falciparum aminopeptidase 1 antigen in Gabonese children living in Makokou and Franceville

2020 ◽  
Vol 200 (3) ◽  
pp. 287-298
Author(s):  
S. L. Oyegue‐Liabagui ◽  
R.‐K. Imboumy‐Limoukou ◽  
C. L. Kouna ◽  
F. Bangueboussa ◽  
M. Schmitt ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antibody Response ◽  
Igg Antibody

scholarly journals Clinical evaluation of serological IgG antibody response on the Abbott Architect for established SARS-CoV-2 infection

2020 ◽  
Vol 26 (9) ◽  
pp. 1256.e9-1256.e11 ◽  
Author(s):  
K.L. Chew ◽  
S.S. Tan ◽  
S. Saw ◽  
A. Pajarillaga ◽  
S. Zaine ◽  
...  
Keyword(s):  
Antibody Response ◽  
Clinical Evaluation ◽  
Igg Antibody ◽  
Abbott Architect

scholarly journals Genetic regulation of the antibody response to H-2Db alloantigens in mice. I. Differences in activation of helper T cells in C57BL/10 and BALB/c congenic strains.

1975 ◽  
Vol 141 (3) ◽  
pp. 573-583 ◽  
Author(s):  
D Wernet ◽  
F Lilly
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Antibody Response ◽  
Genetic Regulation ◽  
Surface Antigens ◽  
T Helper ◽  
Spleen Cells ◽  
Igg Antibody ◽  
Cell Surface Antigens ◽  
Helper Function

B10.A(5R) mice immunized with C57BL/10 spleen cells demonstrate a normal T-cell-mediated cytotoxicity to H-2Db tumor cells but they do not mount any IgG antibody response to H-2Db alloantigens. B10.A(5R) mice do show a high titered IgG response when immunized with A.BY cells, which differ at H-2Db plus non-H-2 cell surface antigens, or with B10.A(2R) cells, which differ at H-2Db, H-2Kk, and H-2Ik cell surface antigens. These findings indicate a failure of the T-helper cells to induce the switch from IgM to IgG when the H-2Db alloantigens are the only difference on the immunizing cell. In immunizing H-2d mice with congenic H-g2 cells which differ only in the H-2Db region, mice of the C57BL/10 background made only IgM antibodies whereas mice of the BALB/c background made IgG antibodies. This comparison confirms that genes separate from H-2 regulate the T-cell helper function. The genes that influence the T-cell helper function do not regulate the T-cell-mediated cytotoxicity.

scholarly journals Generation of Antibody Responses to Pneumococcal Capsular Polysaccharides Is Independent of CD1 Expression in Mice

2009 ◽  
Vol 77 (5) ◽  
pp. 1976-1980 ◽  
Author(s):  
Leen Moens ◽  
Axel Jeurissen ◽  
Stefan Nierkens ◽  
Louis Boon ◽  
Luc Van Kaer ◽  
...  
Keyword(s):  
Antibody Response ◽  
The Elderly ◽  
Immunoglobulin M ◽  
Antibody Responses ◽  
Capsular Polysaccharides ◽  
Wild Type ◽  
Igg Antibody ◽  
Antibody Treatment ◽  
Serious Infection ◽  
Protection Against Infection

ABSTRACT Streptococcus pneumoniae is a bacterial microorganism that frequently causes serious infection, particularly in children and the elderly. Protection against infection with S. pneumoniae is based mainly on the generation of antibodies to the pneumococcal capsular polysaccharides (caps-PS), but the mechanisms responsible for the generation of anticapsular antibodies remain incompletely understood. The aim of the present study was to evaluate the role of CD1-restricted T cells in the antibody response to caps-PS. When immunized with Pneumo23, wild-type mice and CD1 knockout mice on BALB/c and C57BL/6 backgrounds generated immunoglobulin M (IgM) and IgG antibody responses to soluble caps-PS that were comparable. Similar results were obtained after immunization with heat-inactivated S. pneumoniae. The IgM and IgG antibody response of wild-type mice to Pneumo23 was not affected by an antagonizing monoclonal anti-CD1 antibody treatment. In summary, our data provide evidence that the antibody response to caps-PS is generated independently of CD1 expression.

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