GABA uptake and phenotypic characteristics of the subcommissural ependymocytes of the semi-desertic rodent, Meriones shawi: correlation with serotoninergic innervation

1996 ◽  
Vol 285 (3) ◽  
pp. 435-443 ◽  
Author(s):  
A. Laalaoui ◽  
L. Chouaf ◽  
M. Didier-Bazes ◽  
M. Geffard ◽  
M. F. Belin ◽  
...  
Keyword(s):  
Gaba Uptake ◽  
Phenotypic Characteristics ◽  
Serotoninergic Innervation

A form of Autoimmune Diabetes in Adults Named LADA – An Update on Essential Features and Controversies

2019 ◽  
Vol 15 (3) ◽  
pp. 172-173 ◽  
Author(s):  
Valdemar Grill ◽  
Bjørn O. Åsvold
Keyword(s):  
Genetic Background ◽  
Clinical Utility ◽  
Autoimmune Diabetes ◽  
Classical Type ◽  
Phenotypic Characteristics ◽  
Latent Autoimmune Diabetes ◽  
The Impact

Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than “classical” type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged. Despite the absence of a genetic background that is exclusive to LADA, this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems as to therapy and follow-up perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.

scholarly journals Functional and Phenotypic Characteristics of Human Leptin Receptor Mutations

2018 ◽  
Vol 3 (1) ◽  
pp. 27-41 ◽  
Author(s):  
Adriana Nunziata ◽  
Jan-Bernd Funcke ◽  
Guntram Borck ◽  
Julia von Schnurbein ◽  
Stephanie Brandt ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Phenotypic Characteristics

scholarly journals Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug

Drug Research ◽  
2020 ◽  
Author(s):  
Meenakshi Dhanawat ◽  
Sumeet Gupta ◽  
Dinesh Kumar Mehta ◽  
Rina Das
Keyword(s):  
Epileptic Activity ◽  
Aminobutyric Acid ◽  
Gaba Uptake ◽  
Nipecotic Acid ◽  
Design Synthesis ◽  
Hydrophilic Nature ◽  
Carrier Mediated Transport ◽  
Ester Prodrug ◽  
Hplc Data

Nipecotic acid is considered to be one of the most potent inhibitors of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Due to its hydrophilic nature, nipecotic acid does not readily cross the blood-brain barrier (BBB). Large neutral amino acids (LAT1)-knotted nipecotic acid prodrug was designed and synthesized with the aim to enhance the BBB permeation by the use of carrier-mediated transport. The synthesized prodrug was tested in animal models of Pentylenetetrazole (PTZ)-induced convulsions in mice. Further pain studies were carried out followed by neurotoxicity estimation by writhing and rota-rod test respectively. HPLC data suggests that the synthesized prodrug has improved penetration through BBB. Nipecotic acid-L-serine ester prodrug with considerable anti-epileptic activity, and the ability to permeate the BBB has been successfully synthesized. Graphical Abstract.

Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures

1989 ◽  
Vol 168 (2) ◽  
pp. 265-268 ◽  
Author(s):  
Susan F. Gonsalves ◽  
Bonnie Twitchell ◽  
Robert E. Harbaugh ◽  
Povl Krogsgaard-Larsen ◽  
Arne Schousboe
Keyword(s):  
Anticonvulsant Activity ◽  
Gaba Uptake ◽  
Uptake Inhibitor ◽  
Gaba Uptake Inhibitor

scholarly journals Model-Based Patterns of Lymphedema Symptomatology: Phenotypic and Biomarker Characterization

2020 ◽  
Author(s):  
Mei R. Fu ◽  
Bradley E Aouizerat ◽  
Gary Yu ◽  
Yvette Conley ◽  
Deborah Axelrod ◽  
...  
Keyword(s):  
Breast Cancer Survivors ◽  
Latent Class ◽  
Severe Symptom ◽  
Repeated Measure ◽  
Phenotypic Characteristics ◽  
Post Surgery ◽  
Lower Education Level ◽  
Measure Design ◽  
Lower Education ◽  
Symptom Patterns

Abstract Purpose of the Study More than 50% of breast cancer survivors without a diagnosis of lymphedema suffer daily from numerous and co-occurring lymphedema symptoms. This study aimed to identify lymphedema symptom patterns and the association of such patterns with phenotypic characteristics and biomarkers using latent class analysis (LCA). A prospective, descriptive, and repeated-measure design was used to enroll 140 women and collect data. Recent Findings LCA identified three distinct lymphedema symptom classes at 8 weeks and 12 months post-surgery: low, moderate, and severe symptom classes and associated phenotypic characteristics. Participants were more likely to be in the severe symptom classes at 12 months post-surgery if they had lower education level, cording, an axillary syndrome at 8 weeks post-surgery, neoadjuvant chemotherapy, and radiation. Summary Pre-surgery level of IL1-a, IL-6, IL-8, and VEGF was associated with the severe symptom class at 8 weeks post-surgery, suggesting that such biomarkers may be used to predict risk for lymphedema symptoms.

scholarly journals Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A

2014 ◽  
Vol 56 (1) ◽  
Author(s):  
Carolina Stenfeldt ◽  
Juan M Pacheco ◽  
Manuel V Borca ◽  
Luis L Rodriguez ◽  
Jonathan Arzt
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Phenotypic Characteristics ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Virus Strains

Identification of HNF1A-MODY and HNF4A-MODY in Irish families: Phenotypic characteristics and therapeutic implications

2011 ◽  
Vol 37 (6) ◽  
pp. 512-519 ◽  
Author(s):  
M.P. Kyithar ◽  
S. Bacon ◽  
K.K. Pannu ◽  
S.R. Rizvi ◽  
K. Colclough ◽  
...  
Keyword(s):  
Phenotypic Characteristics ◽  
Therapeutic Implications

Synthesis and Biochemical Studies of Spirocyclic Amino Acid Esters, Part 3 Activity of 2-Azaspiro[4.5]decane-6-carboxylates as GABA-Uptake Inhibitors

1996 ◽  
Vol 329 (3) ◽  
pp. 149-154 ◽  
Author(s):  
Wilhelm Fleischhacker ◽  
Silvia Lauritz ◽  
Ernst Urban ◽  
Peter Baumann ◽  
Helmut Bittiger
Keyword(s):  
Amino Acid ◽  
Gaba Uptake ◽  
Amino Acid Esters ◽  
Uptake Inhibitors ◽  
Biochemical Studies ◽  
Gaba Uptake Inhibitors ◽  
Acid Esters
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