A rare case of severe hypertension with hypokalemic metabolic alkalosis in a 14-year-old girl: Answers

2020 ◽  
Vol 35 (9) ◽  
pp. 1633-1638
Author(s):  
Pediredla Karunakar ◽  
Sriram Krishnamurthy ◽  
Aakash Chandran Chidambaram ◽  
Jayaprakash Sahoo ◽  
Sadishkumar Kamalanathan ◽  
...  
Keyword(s):  
Metabolic Alkalosis ◽  
Rare Case ◽  
Severe Hypertension

scholarly journals The co-occurrence of leukemoid reaction and hypercalcemia in a patient with endometrial cancer: A case report and literature review

2021 ◽  
Vol 104 (2) ◽  
pp. 003685042110040
Author(s):  
Weimin Tao ◽  
Qin Yan ◽  
Yao Zhou ◽  
Yanli Wang ◽  
Zhiqiang Liu ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Identification ◽  
Metabolic Alkalosis ◽  
Rare Case ◽  
Symptomatic Treatment ◽  
Clinical Situation ◽  
Paraneoplastic Syndromes ◽  
Leukemoid Reaction ◽  
Clinical Prognosis ◽  
Infection Treatment

Paraneoplastic syndromes are rarely seen in gynecological tumors especially in endometrial cancer. Early identification of paraneoplastic syndromes plays a significant role in the treatment and prognosis of cancer. Here, we reported a rare case with endometrial cancer with a 2.7 cm × 2.2 cm × 3.4 cm lesion in the posterior cervix presenting leukemoid reaction and hypercalcemia as paraneoplastic syndromes simultaneously. During the progress of the endometrial cancer, her leukocyte level rose up to 60.7 × 109/L after anti-infection treatment. Meanwhile, the patient represented a series of severe clinical situation including hypercalcemia, hypokalemia, metabolic alkalosis. and respiratory failure. Finally, the patient died of respiratory circulatory failure 2 weeks later. In addition to symptomatic treatment, possible treatment targeted on the primary tumor as early as possible might help to improve the clinical prognosis.

scholarly journals A rare case of Cushing syndrome by cyclic ectopic-ACTH

2012 ◽  
Vol 56 (5) ◽  
pp. 324-330 ◽  
Author(s):  
Mariana Farage ◽  
Mario Alberto da Dantas Loures Costa ◽  
Amélio Fernando Godoy-Matos
Keyword(s):  
Primary Tumor ◽  
Rare Case ◽  
Glomus Tumor ◽  
Cushing Syndrome ◽  
Severe Hypertension ◽  
Abdominal Fat ◽  
Ectopic Acth ◽  
Mood Changes ◽  
Ectopic Acth Production

ACTH-dependent Cushing syndrome (CS) due to ectopic ACTH production is most times difficult to manage. The identification of the source of ACTH may take many years. Surgery or chemotherapy for the primary tumor is not always possible. Control of Cushing symptoms is many times achieved using medication, or bilateral adrenalectomy in refractory cases. This case presents a Brazilian male who showed severe hypertension, mood changes, muscle weakness, darkening of skin, and increased abdominal fat. An investigation for Cushing syndrome was carried out and, after a four-year follow-up, a carotid glomus tumor (chemodectoma) was confirmed, a rare ectopic ACTH-producing tumor. Besides, the patient presented cyclic Cushing syndrome that was exacerbated by diverticulitis episodes. This case presents interesting pitfalls on diagnosis and management of ACTH-dependent CS. This is the only report of a chemodectoma that produced ACTH in the literature.

A rare cause of severe hypertension with hypokalemic metabolic alkalosis in a 14-year-old girl: Questions

2020 ◽  
Vol 35 (9) ◽  
pp. 1631-1632
Author(s):  
Pediredla Karunakar ◽  
Sriram Krishnamurthy ◽  
Aakash Chandran Chidambaram ◽  
Jayaprakash Sahoo ◽  
Sadishkumar Kamalanathan ◽  
...  
Keyword(s):  
Metabolic Alkalosis ◽  
Severe Hypertension

scholarly journals A Rare Case of Hypokalemia Induced Rhabdomyolysis Secondary to Gitelman Syndrome: An Easily Overlooked Inherited Tubulopathy

2020 ◽  
Vol 21 (2) ◽  
pp. 105-108
Author(s):  
Richmond Ronald Gomes ◽  
Diapankar Kumar Basak ◽  
Akmat Ali
Keyword(s):  
Acute Kidney Injury ◽  
Metabolic Alkalosis ◽  
Rare Case ◽  
Kidney Injury ◽  
Clinical Problem ◽  
Short Review ◽  
Gitelman Syndrome ◽  
Lower Limbs ◽  
Life Threatening ◽  
Common Clinical Problem

Hypokalemia is a common clinical problem in endocrinologists’ and nephrologists’ practice. There are many obvious causes of hypokalemia such as diarrhea, vomiting or diuretics abuse. Other causes such as tubulopathies are rarely observed and their diagnosis is more challenging. There are many inherited and acquired tubulopathies causing hypokalemia, sometimes severe and life-threatening. We report a case of a middle aged female patient who presented with weakness of upper and lower limbs, muscle pain and oliguria. On evaluation, she had hypokalemia, hypomagnesemia, metabolic alkalosis and hypocalciuria and diagnosis of Gitelman syndrome was established. In addition, she had acute kidney injury (AKI ) due to rhabdomyolysis secondary to hypokalemia. A short review on the etiology, pathogenesis and management of Gitelman syndrome is presented. J MEDICINE JUL 2020; 21 (2) : 105-108

scholarly journals Severe hypertension complicating pregnancy, pheochromocytoma: A rare case report

2020 ◽  
Vol 7 (1) ◽  
pp. 129-132
Author(s):  
Ruchi Kalra,= ◽  
◽  
Sushil Jindal ◽  
Sanjay P Dave ◽  
Shefali Bansal ◽  
...  
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Severe Hypertension ◽  
Rare Case Report

scholarly journals Gitelman Syndrome: A Rare Case of Hypokalaemia and a Novel Mutation

2021 ◽  
Author(s):  
Maria Clara Novais de Matos ◽  
Fábio Correia ◽  
Maria Inês Silva ◽  
Sofia Carola ◽  
Ana Órfão ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Sodium Chloride ◽  
Metabolic Alkalosis ◽  
Rare Case ◽  
Novel Mutation ◽  
Gitelman Syndrome ◽  
Clinical Approach ◽  
Slc12a3 Gene ◽  
Sodium Chloride Cotransporter ◽  
Renal Tubulopathy

Gitelman syndrome (GS) is a hereditary renal tubulopathy caused by mutations in the SLC12A3 gene which encodes the thiazide-sensitive apical sodium-chloride cotransporter. GS is characterized by hypokalaemia, hypomagnesaemia and metabolic alkalosis. Treatment is based on potassium and magnesium replacement ad eternum. We present the case of a young man with palpitations and persistent hypokalaemia, who was diagnosed with GS. Genetic testing revealed 2 mutations in the gene SLC12A3 of combined heterozygosity, both considered pathological. Interestingly, 1 of these mutations was not yet described in the literature or in the reviewed databases. We also discuss the clinical approach and the specificities of managing this rare hereditary renal tubulopathy.

scholarly journals A rare case of acute kidney injury and anemia induced by hypercalcemia

2019 ◽  
Vol 9 (2) ◽  
Author(s):  
Suparpit Von Bormann ◽  
Sirilak Suksompong ◽  
Benno Von Bormann
Keyword(s):  
Vitamin D ◽  
Acute Kidney Injury ◽  
Serum Creatinine ◽  
Rare Case ◽  
Severe Hypertension ◽  
Kidney Injury ◽  
Hemoglobin Concentration ◽  
Plasma Calcium ◽  
Healthy Patient ◽  
Plasma Calcium Level

Hypercalcemia may result in acute kidney injury (AKI) and arterial hypertension. Anemia as a consequence of this constellation is nowhere described. A female patient underwent total thyroidectomy in 2007, since then being under continuous daily medication with 100 μg thyroxin, 1.6 g calcium and 1.0 μg alfacalcidol. In 2017, after accidentally overdosing alfacalcidol fourfold for several weeks leading to massive hypercalcemia (plasma calcium level 16.7 mg/dL), the otherwise healthy patient developed symptoms of AKI, such as serum creatinine 2.48 mg/dL, plus severe hypertension and acute anemia (hemoglobin concentration 10.2 g/dL). After cessation of calcium and alfacalcidol medication for 9 days, hypercalcemia and AKI symptoms and anemia recovered within 14 and after 62 days, respectively. The patient is currently free of complaints and has been sufficiently treated with half of the yearslong pre-event calcium/alfacalcidol dose. In conclusion, hypercalcemia with consecutive AKI after vitamin D overdose can occur asymptomatically. The treatment does not compulsorily include washout by hyperhydration and diuretics. AKI may lead to anemia, possibly caused by the deterioration of the release of erythropoietin.

Sign in / Sign up

Export Citation Format

Share Document