scholarly journals The co-occurrence of leukemoid reaction and hypercalcemia in a patient with endometrial cancer: A case report and literature review

2021 ◽  
Vol 104 (2) ◽  
pp. 003685042110040
Author(s):  
Weimin Tao ◽  
Qin Yan ◽  
Yao Zhou ◽  
Yanli Wang ◽  
Zhiqiang Liu ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Identification ◽  
Metabolic Alkalosis ◽  
Rare Case ◽  
Symptomatic Treatment ◽  
Clinical Situation ◽  
Paraneoplastic Syndromes ◽  
Leukemoid Reaction ◽  
Clinical Prognosis ◽  
Infection Treatment

Paraneoplastic syndromes are rarely seen in gynecological tumors especially in endometrial cancer. Early identification of paraneoplastic syndromes plays a significant role in the treatment and prognosis of cancer. Here, we reported a rare case with endometrial cancer with a 2.7 cm × 2.2 cm × 3.4 cm lesion in the posterior cervix presenting leukemoid reaction and hypercalcemia as paraneoplastic syndromes simultaneously. During the progress of the endometrial cancer, her leukocyte level rose up to 60.7 × 109/L after anti-infection treatment. Meanwhile, the patient represented a series of severe clinical situation including hypercalcemia, hypokalemia, metabolic alkalosis. and respiratory failure. Finally, the patient died of respiratory circulatory failure 2 weeks later. In addition to symptomatic treatment, possible treatment targeted on the primary tumor as early as possible might help to improve the clinical prognosis.

Clinical and Morphological Features of Myocardial Damage and the Course of Fulminant Myocarditis on the Background of СOVID-19, Diagnosis and Treatment Tactics

2020 ◽  
Vol 75 (5S) ◽  
pp. 414-425
Author(s):  
Olga S. Oynotkinova ◽  
Evgenii L. Nikonov ◽  
Oleg V. Zayratyants ◽  
Elena V. Rzhevskaya ◽  
Evgenii V. Krukov ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Myocardial Damage ◽  
Heart Rhythm ◽  
Microvascular Dysfunction ◽  
Symptomatic Treatment ◽  
Clinical Situation ◽  
Diagnosis And Treatment ◽  
Screening Tests ◽  
Fulminant Myocarditis ◽  
Heart Rhythm Disorders

In a review article based on my own clinical experience of managing patients with acute myocardial injury and fulminant myocarditis, taking into account expert recommendations on the clinical treatment of myocardial damage associated with novel coronavirus infection a National clinical geriatric medical research center, division of cardiovascular diseases, the Chinese geriatrics society, Department of cardiology, Beijing Medical Association and European clinics discusses the pathogenesis, diagnosis and treatment of myocardial damage and FM patients, infected with SARS-CoV-2 in the context of the COVID-19 pandemic. Clinical features and diagnostic criteria are presented, including screening tests of markers of myocardial damage in the form of a highly sensitive troponin test, a natriuretic peptide. The article discusses in detail the pathogenesis and mechanisms of myocardial damage, including immune mechanisms, cytokine storm, systemic inflammation with macro- and microvascular dysfunction and the development of myocardial dysfunction with acute heart failure, hypotension, cardiogenic shock and/or life-threatening heart rhythm disorders caused by hypoxia and metabolic disorders at the cellular level. Features of the clinical course of fulminant myocarditis in infected patients (SARS-CoV-2) in the conditions of the COVID-19 pandemic are presented. For the first time, a detailed histo-morphological analysis of pathological myocardial injuries and complications is presented on the basis of unique autopsy material on post-mortem diagnostics of various pathoanatomic autopsies of those who died from COVID-19 in Moscow. Based on the clinical, functional and morphological material, the Protocol of etiopathogenetic treatment is presented. The basis of standard therapy is considered antiviral drugs, immunoglobulin G, the use of monoclonal antibodies to interleukin-6, anticoagulants, glucocorticoids, depending on the clinical situation, cardioprotectors and symptomatic treatment are recommended to maintain the heart, which in combination can achieve a certain clinical effectiveness. As adjuvant cardioprotective targeted therapy, the sodium salt of phosphocreatine is considered in order to preserve the myocardium, maintain its contractility and vital activity.

Neurologic complications in patients with lymphoid cancer

Blood ◽  
2021 ◽  
Author(s):  
Lakshmi Nayak ◽  
Tracy T Batchelor
Keyword(s):  
Nervous System ◽  
Case Studies ◽  
Early Identification ◽  
Vascular Complications ◽  
Paraneoplastic Syndromes ◽  
Neurologic Complications ◽  
Local Spread ◽  
Neurologic Deficits ◽  
Clinical Scenarios ◽  
Oncologic Therapy

Neurologic complications of lymphoid cancer can be challenging to recognize and treat. The nervous system can be affected directly by hematogenous or local spread of lymphoma. Indirect neurologic effects of lymphoma include paraneoplastic syndromes and vascular complications. Lymphoma treatments can also cause neurologic complications. Early identification and treatment are crucial to stabilize or reverse neurologic deficits, prevent further nervous system injury, and to optimize overall oncologic therapy. This article provides an overview of different neurologic complications of lymphoma and its treatments, in addition to presentation of case studies that emphasize commonly encountered clinical scenarios.

scholarly journals Milk-Alkali Syndrome: An Unusual Cause of Acute Renal Failure

2003 ◽  
Vol 2 (2) ◽  
pp. 64-65
Author(s):  
Azhar Ahmad ◽  
◽  
Rodney Dathan ◽  
Keyword(s):  
Renal Failure ◽  
Calcium Carbonate ◽  
Metabolic Alkalosis ◽  
Case Reports ◽  
Symptomatic Treatment ◽  
Self Medication ◽  
H2 Receptor Antagonists ◽  
Over The Counter ◽  
Ulcer Disease

Milk–alkali syndrome is described as a triad of hypercalcaemia, metabolic alkalosis and renal impairment, resulting from the ingestion of calcium and absorbable alkali1. It was more common in the early part of the century when antacids were used for the symptomatic treatment of peptic ulcer disease. The use of antacids has since been overtaken by H2- receptor antagonists and proton pump inhibitors. More recently, there have been various case reports of milk-alkali syndrome due to the increasing use of calcium carbonate as part of the management of osteoporosis and chronic renal failure, and also the increasing availability of calcium carbonate ‘over the counter’. We describe a case of milk-alkali syndrome due to self-medication with calcium carbonate.

scholarly journals Can 2-Aticyto Complex be an Effective Agent for Recovery of The Symptoms and Enhancing Laboratory Parameters in COVID-19 Patients?

2021 ◽  
Vol 3 (2) ◽  
pp. 35-39
Author(s):  
Ferhan Kerget ◽  
Buğra Kerget ◽  
Alperen Aksakal ◽  
Abdullah Osman Koçak
Keyword(s):  
Clinical Symptoms ◽  
Clinical Course ◽  
Symptomatic Treatment ◽  
Clinical Situation ◽  
National Guideline ◽  
Control Group ◽  
Effective Agent ◽  
Laboratory Parameters ◽  
Taste And Smell ◽  
D Dimer

Background: SARS-CoV-2 (Covid-19) pandemic which was firstly identified in Wuhan/China in December 2019.There still exists no precise treatment for this pandemic yet despite many agents are tried in prophylaxis and treatment for Covid-19. In this study, we aimed to investigate the efficacy of 2-aticyto complex in clinical course in these patients. Materials and Methods: 150 patients who applied to the Infection Diseases Polyclinics between dates September 2020-November 2020 having diagnosed with Covid-19 were included in our study. The patients were randomized into 2 groups (75 in each group) of which the first group only had the treatment of National Guideline and the second group had Viruthol® including 2-aticyto complex (at the dose of 27000 mcg/day) in addition to the treatment of the National Guideline. The laboratory parameters, clinical outcomes and the first day on which PCR result turned into negative of the patients were compared. Results: In Viruthol® group, LDH, CRP, D-Dimer and ferritin levels were significantly decreased compared to the control group, while lymphocyte levels were higher. (p=0.02, p=0.001, p=0.01, p=0.02, p=0,001 respectively).  In addition to that, clinical symptoms such as fever, headache, weakness, loss of taste and smell and muscle-joint pain recovered more rapidly in contrast with the control group (p=0.001, p=0.05, p=0.001, p=0.001, p=0.001, respectively). PCR results of the Viruthol® group turned negative in a statistically significant shorter period of time with respect to the control group (p=0.001). Conclusion: Viruthol® containing 2-aticyto complex may be an agent that can be used both symptomatic treatment and improving the clinical situation and recovery of the patients followed up for Covid-19.

scholarly journals Osteochondritis Dissecans of the Capitellum: A Case Report of Successful Arthroscopic Treatment

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
J. Ribeiras Cabral ◽  
R. Henriques ◽  
J. Arvela Matoso ◽  
S. Martins ◽  
M. Sarmento
Keyword(s):  
Osteochondritis Dissecans ◽  
Early Identification ◽  
Rare Case ◽  
White Male ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Successful Result ◽  
Case Presentation ◽  
History Of ◽  
Prompt Diagnosis

Introduction.Osteochondritis dissecans (OCD) of the capitellum is a localized disorder of the subchondral bone, in a region with limited healing capacity. Although its aetiology is still unknown, it has been associated with repetitive microtrauma. The natural history of this disease involves the evolution for degenerative joint disease in approximately half of the patients, with early identification and treatment being critical to optimizing the outcome.Case Presentation.We present a rare case in our practice, illustrating a capitellar OCD in a fifteen-year-old White male without an identified cause of repetitive microtrauma.Conclusion.In this case prompt diagnosis and arthroscopic-assisted treatment led to a successful result.

A rare case of severe hypertension with hypokalemic metabolic alkalosis in a 14-year-old girl: Answers

2020 ◽  
Vol 35 (9) ◽  
pp. 1633-1638
Author(s):  
Pediredla Karunakar ◽  
Sriram Krishnamurthy ◽  
Aakash Chandran Chidambaram ◽  
Jayaprakash Sahoo ◽  
Sadishkumar Kamalanathan ◽  
...  
Keyword(s):  
Metabolic Alkalosis ◽  
Rare Case ◽  
Severe Hypertension

scholarly journals A Rare Case of Recurrent Hematuria from Right Kidney: Radiologic Diagnosis and Treatment

ISRN Urology ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Pietro Venetucci ◽  
Mario Quarantelli ◽  
Vittorio Iaccarino
Keyword(s):  
Rare Case ◽  
Clinical Situation ◽  
Lumbar Pain ◽  
Ovarian Vein ◽  
Inflammatory Stimulus ◽  
Radiologic Diagnosis ◽  
Macroscopic Hematuria ◽  
Computed Tomography Images ◽  
Contrast Enhanced ◽  
Recurrent Hematuria

We report the case of a young woman admitted because of several and recurring episodes of macroscopic hematuria beginned after her first pregnancy. Contrast-enhanced multidetector computed tomography images showed dilated ovarian veins due to a typical pelvic varicocele. We supposed to be a right ovarian vein syndrome, a rare clinical situation characterized by an anomalous compression of the lumbar ureter by the ectasic ovarian vein; this condition may cause a chronic inflammatory stimulus above the urothelial mucosa with a following hematuria. All symptoms were solved by an endovascular treatment through the sclero-embolisation of the pelvic varicocele. After eighteen months the patient didn't present hematuria anymore and she no longer complained about her right side lumbar pain.

scholarly journals Persistent genital arousal disorder: always look beyond the surface - a case report

2021 ◽  
Vol 10 (4) ◽  
pp. 1691
Author(s):  
Rita Sarabando ◽  
Natacha Sousa ◽  
Ana C. Borges ◽  
Cristina Nogueira-Silva
Keyword(s):  
Endometrial Cancer ◽  
Rare Case ◽  
Case Reports ◽  
Rare Condition ◽  
Specific Context ◽  
Comprehensive Review ◽  
Genital Arousal ◽  
Arousal Disorder ◽  
Multiple Diagnosis

Persistent genital arousal disorder is a rare condition characterized by unwanted intrusive symptoms of sexual arousal without specific context. Their possible aetiologies and treatments are multiple and mostly based on case reports. We aim to do a comprehensive review of persistent genital arousal disorder and describe a case of a postmenopausal woman who developed this disease and, during the follow-up, was diagnosed with advanced endometrial cancer, reminding physicians to keep in mind the possibility of multiple diagnosis in the same patient, including malignancy. Although there is no description of this association in the literature, the possible aetiologies of persistent genital arousal disorder are diverse, and we sought this rare case should be disclosed.

scholarly journals SAT-494 A Very Rare Case: Hypercalcemia Caused by Ectopic PTH Secretion in Endometrial Cancer

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Nour Batarseh ◽  
Farah Al Sabie ◽  
Carmella Evans-Molina
Keyword(s):  
Endometrial Cancer ◽  
Rare Case
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