scholarly journals Expression of angiotensin II type 1 and type 2 receptor mRNAs in the gastric mucosa of Helicobacter pylori-infected Mongolian gerbils

2011 ◽  
Vol 46 (10) ◽  
pp. 1177-1186 ◽  
Author(s):  
Mitsushige Sugimoto ◽  
Tomoyuki Ohno ◽  
Yoshio Yamaoka
Keyword(s):  
Helicobacter Pylori ◽  
Angiotensin Ii ◽  
Gastric Mucosa ◽  
Mongolian Gerbils ◽  
Receptor Mrnas

S1645 Gastric Mucosal Expression of Angiotensin II Type 1 and Type 2 Receptor mRNA in Helicobacter pylori-Induced Mongolian Gerbils

2010 ◽  
Vol 138 (5) ◽  
pp. S-245
Author(s):  
Mitsushige Sugimoto ◽  
Tomoyuki Ohno ◽  
David Y Graham ◽  
Yoshio Yamaoka
Keyword(s):  
Helicobacter Pylori ◽  
Angiotensin Ii ◽  
Mongolian Gerbils ◽  
Receptor Mrna

scholarly journals Helicobacter pylori–binding nonacid glycosphingolipids in the human stomach

2018 ◽  
Vol 293 (44) ◽  
pp. 17248-17266 ◽  
Author(s):  
Chunsheng Jin ◽  
Angela Barone ◽  
Thomas Borén ◽  
Susann Teneberg
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Structural Complexity ◽  
Human Stomach ◽  
Carbohydrate Binding ◽  
Human Gastric Mucosa ◽  
H Pylori ◽  
Contrast Information

Helicobacter pylori has a number of well-characterized carbohydrate-binding adhesins (BabA, SabA, and LabA) that promote adhesion to the gastric mucosa. In contrast, information on the glycoconjugates present in the human stomach remains unavailable. Here, we used MS and binding of carbohydrate-recognizing ligands to characterize the glycosphingolipids of three human stomachs from individuals with different blood group phenotypes (O(Rh−)P, A(Rh+)P, and A(Rh+)p), focusing on compounds recognized by H. pylori. We observed a high degree of structural complexity, and the composition of glycosphingolipids differed among individuals with different blood groups. The type 2 chain was the dominating core chain of the complex glycosphingolipids in the human stomach, in contrast to the complex glycosphingolipids in the human small intestine, which have mainly a type 1 core. H. pylori did not bind to the O(Rh−)P stomach glycosphingolipids, whose major complex glycosphingolipids were neolactotetraosylceramide, the Lex, Lea, and H type 2 pentaosylceramides, and the Ley hexaosylceramide. Several H. pylori-binding compounds were present among the A(Rh+)P and A(Rh+)p stomach glycosphingolipids. Ligands for BabA-mediated binding of H. pylori were the Leb hexaosylceramide, the H type 1 pentaosylceramide, and the A type 1/ALeb heptaosylceramide. Additional H. pylori-binding glycosphingolipids recognized by BabA-deficient strains were lactosylceramide, lactotetraosylceramide, the x2 pentaosylceramide, and neolactohexaosylceramide. Our characterization of human gastric receptors required for H. pylori adhesion provides a basis for the development of specific compounds that inhibit the binding of this bacterium to the human gastric mucosa.

Blockade of central angiotensin II type 1 and type 2 receptors suppresses adrenalectomy-induced NaCl intake in rats

1996 ◽  
Vol 66 (1-2) ◽  
pp. 47-50 ◽  
Author(s):  
O. Galaverna ◽  
C. Polidori ◽  
R.R. Sakai ◽  
F. Liénard ◽  
S.Y. Chow ◽  
...  
Keyword(s):  
Angiotensin Ii

Angiotensin II-induced thirst, but not sodium appetite, via AT1 receptors in organum cavum prelamina terminalis

1995 ◽  
Vol 268 (6) ◽  
pp. R1401-R1405 ◽  
Author(s):  
M. el Ghissassi ◽  
S. N. Thornton ◽  
S. Nicolaidis
Keyword(s):  
Angiotensin Ii ◽  
Salt Intake ◽  
High Sensitivity ◽  
Ang Ii ◽  
Nacl Solution ◽  
At1 Receptors ◽  
Sodium Appetite ◽  
Specific Antagonist

The angiotensin receptor specificity, with respect to fluid intake, of the organum cavum prelamina terminalis (OCPLT), a recently discovered discrete forebrain structure with high sensitivity to angiotensin II (ANG II), was investigated. ANG II (10 ng) microinjected into the OCPLT significantly increased water consumption but did not induce intake of a hypertonic (3%) NaCl solution. Losartan, an ANG II type 1 (AT1) receptor-specific antagonist, produced dose-related (1-100 ng) inhibition of ANG II-induced drinking. The ANG II type 2 receptor-specific antagonist CGP-42112A was ineffective. Intake of the 3% NaCl solution in response to microinjection of either of the antagonists into the OCPLT was never observed. These findings suggest that water intake produced by microinjection of ANG II into the OCPLT is mediated by AT1 receptors uniquely and that, in contrast to other regions of the brain, these receptors do not induce salt intake when stimulated by ANG II.

Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: An in vitro gene transfer study

Life Sciences ◽  
1998 ◽  
Vol 63 (19) ◽  
pp. PL289-PL295 ◽  
Author(s):  
Takehiko Yamada ◽  
Masahiro Akishita ◽  
Matthew J. Pollman ◽  
Gary H. Gibbons ◽  
Victor J. Dzau ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Gene Transfer ◽  
Cell Apoptosis ◽  
Receptor Action ◽  
Muscle Cell Apoptosis ◽  
Transfer Study
Sign in / Sign up

Export Citation Format

Share Document