Angiotensin II type 1 and type 2 receptors bind angiotensin II through different types of epitope recognition

1999 ◽  
Vol 17 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Shin-ichiro Miura ◽  
Sadashiva S. Karnik
Keyword(s):  
Angiotensin Ii ◽  
Epitope Recognition ◽  
Different Types

FUNCTIONAL STATUS AND ADAPTIVE POTENTIAL IN FOREIGN STUDENTS WITH DIFFERENT TYPES OF VEGETATIVE REGULATION DURING TUITION

2020 ◽  
pp. 118-126
Author(s):  
A.M. Satarkulova
Keyword(s):  
Heart Rate ◽  
Foreign Students ◽  
Autonomic Regulation ◽  
The Body ◽  
Functional Changes ◽  
Different Types ◽  
Type 3 ◽  
Adaptive Abilities

The assessment and dynamic control over students’ status is a very important task. It allows timely detection of prenosological status prior to pathology and health maintenance in students. The objective of the paper is to assess the adaptive abilities of the body, to analyze changes in heart rate variability indicators in students with various types of autonomic regulation, to identify prenosological status and precursory pathological symptoms. Materials and Methods. The study enrolled 302 students from India, aged 21.54±1.43. Programming complex «Psychophysiologist» was used to register the main HRV parameters within 5 minutes. Health status was evaluated according to the index of functional changes and the scale of functional states. Results. N.I. Shlyk (2009) distinguished two groups of students with different types of autonomic regulation: type 1 (53 %) with moderate and type 2 (5 %) with marked characteristics of central regulation profile, type 3 (35 %) with moderate and type 4 (7 %) with marked characteristics of autonomous regulation profile. Main parameters of HRV and adaptation potential were defined for each student.All the parameters characterized functional and health status. Conclusions. It was shown that 82 % of trial subjects (type 1), 53 % (type 2), 94 % (type 3) and 95 % (type 4) demonstrated satisfactory adaptation and their physiological processes were at an optimal level. 18 % of students (type 1) demonstrated reduced adaptive abilities of the body. Moreover, they were under moderate stress. 47 % of subjects (type 2) were also under a significant stress, which was proven by excessively high SI, low SDNN and TP, and an increased index of functional changes. 5 % of students (type 4) revealed dysfunctional characteristics in the heart rhythm, peculiar to pathology. Keywords: foreign students, heart rate variability, types of autonomic regulation, adaptation potential, functional status. Оценка состояния студентов и динамический контроль за ним является важной задачей, поскольку позволяет своевременно выявлять у студентов донозологические состояния, предшествующие патологии, и способствовать сохранению здоровья. Цель. Оценка адаптивных возможностей организма, анализ изменений показателей вариабельности сердечного ритма у студентов с различными типами вегетативной регуляции, выявление донозологических состояний и ранних признаков патологии. Материалы и методы. В исследовании участвовало 302 студента в возрасте 21,54+1,43 года из Индии. Регистрировались основные параметры ВСР в течение 5 мин с использованием программно-аппаратного комплекса «Психофизиолог». Состояние и уровень здоровья оценивались по индексу функциональных изменений и шкале функциональных состояний. Результаты. По способу, предложенному Н.И. Шлык, выделены группы студентов с различными типами вегетативной регуляции: I (53 %) и II типы (5 %) – с умеренным и выраженным преобладанием центрального контура регуляции соответственно, III (35 %) и IV типы (7 %) – с умеренным и выраженным преобладанием автономного контура регуляции соответственно. У каждого из студентов определены основные параметры ВСР и адаптационного потенциала, характеризующие функциональное состояние и уровень здоровья. Выводы. Показано, что для 82 % обследуемых с I типом, 53 % со II типом, 94 % c III типом и 95 % с IV типом регуляции характерно состояние удовлетворительной адаптации, физиологические процессы сохраняются на оптимальном уровне. В группе студентов I типа у 18 % студентов адаптивные возможности организма снижены, выявлено состояние умеренного напряжения. У 47 % обследуемых II типа также зафиксировано состояние резко выраженного напряжения, индикатором которого является чрезмерно высокое значение SI, низкие величины SDNN и ТP, повышенное значение индекса функциональных изменений. В группе студентов с IV типом у 5 % учащихсяв регуляции ритма сердца выявлены дисфункциональные признаки, характерные для патологии. Ключевые слова: иностранные студенты, вариабельность сердечного ритма, типы вегетативной регуляции, адаптационный потенциал, функциональное состояние.

Blockade of central angiotensin II type 1 and type 2 receptors suppresses adrenalectomy-induced NaCl intake in rats

1996 ◽  
Vol 66 (1-2) ◽  
pp. 47-50 ◽  
Author(s):  
O. Galaverna ◽  
C. Polidori ◽  
R.R. Sakai ◽  
F. Liénard ◽  
S.Y. Chow ◽  
...  
Keyword(s):  
Angiotensin Ii

COEVALNESS OF INSECT TRACE FOSSILS AND TRACE-BEARING ROCKS, A CASE STUDY FROM THE PLIO?-PLEISTOCENE OF SW SPAIN

Palaios ◽  
2021 ◽  
Vol 36 (3) ◽  
pp. 115-121
Author(s):  
EDUARDO MAYORAL ◽  
JORGE F. GENISE ◽  
FRANCISCO J. RODRÍGUEZ-TOVAR ◽  
ANA SANTOS
Keyword(s):  
Fossil Record ◽  
Field Research ◽  
Sw Spain ◽  
Modern Age ◽  
Different Types ◽  
The Matrix ◽  
Time Gap

ABSTRACT Plio?-Pleistocene outcrops located at the southwestern edge of the Guadalquivir Basin in the area of Lepe (Huelva, Spain) provide an interesting example for studying the contemporaneity of traces with the rocks that contain them. Two different types of cells compatible with the ichnogenera Celliforma (Type 1) and Palmiraichnus (Type 2) were found in these outcrops. Their walls were constructed with the same material as the matrix and our first research in the area showed no extant bees producing them suggesting that they were coeval with the trace-bearing rocks. The case of the “Palmiraichnus-like” Type 2 cells was misleading because of its similarity with Palmiraichnus described from the region in the Canary Islands and Balearic Archipelago (Spain). Two determining features were vital in clarifying this first appearance. In the Palmiraichnus-like cells we found remains of a larval cocoon in one cell that could be dated by C14, giving a modern age. In the Celliforma-like cells more field research in the area allow us to observe extant bees nesting in these rocks in autumn. Ichnological literature show a few cases of asynchronies involving extant traces found mostly in Paleozoic and Mesozoic rocks. In contrast, the case presented herein indicates the time gap between the bearing rocks and the Lepe traces was shorter (ca. 12 ky–2.6 My), enhancing the similarity of traces and rocks and thus their potential coevalness. This case may serve as a warning about other potential examples in the fossil record in which relatively short asynchronies between traces and paleosols exist.

Angiotensin II-induced thirst, but not sodium appetite, via AT1 receptors in organum cavum prelamina terminalis

1995 ◽  
Vol 268 (6) ◽  
pp. R1401-R1405 ◽  
Author(s):  
M. el Ghissassi ◽  
S. N. Thornton ◽  
S. Nicolaidis
Keyword(s):  
Angiotensin Ii ◽  
Salt Intake ◽  
High Sensitivity ◽  
Ang Ii ◽  
Nacl Solution ◽  
At1 Receptors ◽  
Sodium Appetite ◽  
Specific Antagonist

The angiotensin receptor specificity, with respect to fluid intake, of the organum cavum prelamina terminalis (OCPLT), a recently discovered discrete forebrain structure with high sensitivity to angiotensin II (ANG II), was investigated. ANG II (10 ng) microinjected into the OCPLT significantly increased water consumption but did not induce intake of a hypertonic (3%) NaCl solution. Losartan, an ANG II type 1 (AT1) receptor-specific antagonist, produced dose-related (1-100 ng) inhibition of ANG II-induced drinking. The ANG II type 2 receptor-specific antagonist CGP-42112A was ineffective. Intake of the 3% NaCl solution in response to microinjection of either of the antagonists into the OCPLT was never observed. These findings suggest that water intake produced by microinjection of ANG II into the OCPLT is mediated by AT1 receptors uniquely and that, in contrast to other regions of the brain, these receptors do not induce salt intake when stimulated by ANG II.

scholarly journals Number of cases of type 1 and 2 diabetes diagnosed in Amapá between 2007 and 2012

2020 ◽  
pp. 18-26
Author(s):  
Kauê de Melo Souza ◽  
Lucas Facco ◽  
Amanda Alves Fecury ◽  
Maria Helena Mendonça de Araújo ◽  
Euzébio de Oliveira ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Genetic Factors ◽  
Sedentary Lifestyle ◽  
High Rate ◽  
Main Risk Factor ◽  
Food Education ◽  
Different Types

Diabetes mellitus is a succession of different types of disorders in metabolism that are characterized by causing a high rate of blood sugar. Because it is a disease with genetic factors type 1 diabetes has as main risk factor heredity, while type 2 diabetes besides these factors, includes obesity, high blood pressure, poor food education and advancing age. This study aims to show the number of cases of type 1 and 2 diabetes diagnosed in Amapá with the variables gender, age group, sedentary lifestyle, overweight, smoking, between 2007 and 2012. The data for the research were taken from the computer department of SUS, DATASUS (http://datasus.saude.gov.br). Type 1 and 2 diabetes mellitus (DM1 and DM2) are diseases that are tied to disturbances in production or in the efficient use of insulin. Smoking, as well as sedentary lifestyle and overweight are important risk factors for the development of DM2. Type 2 diabetes mellitus provides the development of various organic nerve lesions. In addition, DM2, through its chronicity, enables the development of retinopathies, nephropathies and other conditions negative to the individual’s health.

Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: An in vitro gene transfer study

Life Sciences ◽  
1998 ◽  
Vol 63 (19) ◽  
pp. PL289-PL295 ◽  
Author(s):  
Takehiko Yamada ◽  
Masahiro Akishita ◽  
Matthew J. Pollman ◽  
Gary H. Gibbons ◽  
Victor J. Dzau ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Gene Transfer ◽  
Cell Apoptosis ◽  
Receptor Action ◽  
Muscle Cell Apoptosis ◽  
Transfer Study

scholarly journals High-aluminum orthopyroxene megacrysts (HAOM) in the Ahvenisto complex, SE Finland, and the polybaric crystallization of massif-type anorthosites

2019 ◽  
Vol 175 (1) ◽  
Author(s):  
Aku Heinonen ◽  
Heli Kivisaari ◽  
Radoslaw M. Michallik
Keyword(s):  
Host Rock ◽  
Compositional Evolution ◽  
Al Content ◽  
Rock Types ◽  
Global Comparison ◽  
Different Types ◽  
Anorthosite Complex ◽  
High Aluminum

AbstractThe occurrence of high-aluminum orthopyroxene megacrysts (HAOMs) in several massif-type Proterozoic anorthosite complexes has been used as evidence of their polybaric crystallization. Here, we report such petrographic and geochemical (XRF and EMPA) evidence from HAOMs discovered in the 1.64 Ga Ahvenisto rapakivi granite—massif-type anorthosite complex in southeastern Finland. Two different types of HAOMs were recognized: type 1 HAOMs are individual, euhedral-to-subhedral crystals, and up to 15 cm in diameter, and type 2 HAOMs occur in pegmatitic pockets closely associated with megacrystic (up to 30 cm long) plagioclase. The type 1 megacrysts in particular are surrounded by complex corona structures composed of plagioclase, low-Al orthopyroxene, iddingsite (after olivine), and sulfides. Orthopyroxene crystallization pressure estimates based on an Al-in-Opx geobarometer reveal a three-stage compositional evolution in both textural HAOM types. The Al content decreases significantly from the core regions of the HAOM (4.4–7.6 wt% Al2O3), through the rims (1.3–3.6 wt%), into the host rock (0.5–1.5 wt%). Enstatite compositions overlap, but are generally higher in the cores (En~60–70) and rims (En~50–70) of the HAOMs than in the host rock (En~45–60) orthopyroxenes. The highest recorded Al abundances in the HAOM cores correspond to crystallization pressures of up to ~ 1.1 GPa (~ 34 km depth), whereas the HAOM rims have crystallized at lower pressures (max. ~ 0.5 GPa, 20 km depth). The highest pressure estimates for the host rock orthopyroxene were ~ 0.2 GPa (< 7 km depth). These observations confirm the polybaric magmatic evolution of the Ahvenisto anorthosites and suggest that the entire 1.65–1.55 Ga Fennoscandian rapakivi suite was emplaced at a relatively shallow level (< 7 km depth) in the upper crust. Global comparison to similar rock types reveals remarkable similarities in the petrogenetic processes controlling HAOM composition and evolution of anorthosite parental magmas.

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