scholarly journals Adiponectin is positively associated with insulin resistance in subjects with type 2 diabetic nephropathy and effects of angiotensin II type 1 receptor blocker losartan

2009 ◽  
Vol 24 (6) ◽  
pp. 1876-1883 ◽  
Author(s):  
L. L. Guo ◽  
Y. Pan ◽  
H. M. Jin
Keyword(s):  
Insulin Resistance ◽  
Diabetic Nephropathy ◽  
Angiotensin Ii ◽  
Receptor Blocker ◽  
Type 2 Diabetic

scholarly journals Amelioration of Cognitive Impairment in the Type-2 Diabetic Mouse by the Angiotensin II Type-1 Receptor Blocker Candesartan

Hypertension ◽  
2007 ◽  
Vol 50 (6) ◽  
pp. 1099-1105 ◽  
Author(s):  
Kana Tsukuda ◽  
Masaki Mogi ◽  
Jian-Mei Li ◽  
Jun Iwanami ◽  
Li-Juan Min ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Angiotensin Ii ◽  
Diabetic Mouse ◽  
Receptor Blocker ◽  
Type 2 Diabetic

Esculetin ameliorates insulin resistance and type 2 diabetic nephropathy through reversal of histone H3 acetylation and H2A lysine 119 monoubiquitination

2017 ◽  
Vol 35 ◽  
pp. 256-266 ◽  
Author(s):  
Almesh Kadakol ◽  
Vajir Malek ◽  
Santosh Kumar Goru ◽  
Anuradha Pandey ◽  
Nisha Sharma ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Diabetic Nephropathy ◽  
Histone H3 ◽  
Histone H3 Acetylation ◽  
H3 Acetylation ◽  
Type 2 Diabetic

scholarly journals Advances in the Renin-Angiotensin-Aldosterone System: Relevance to Diabetic Nephropathy

2008 ◽  
Vol 8 ◽  
pp. 434-445 ◽  
Author(s):  
Audrey Koitka ◽  
Christos Tikellis
Keyword(s):  
Diabetic Nephropathy ◽  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Renal Disease ◽  
Converting Enzyme ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Angiotensin Type 2 Receptor

Hypertension is now recognized as a key contributory factor to the development and progression of kidney disease in both type 1 and type 2 diabetes. The renin angiotensin system (RAS) and its effector molecule angiotensin II, in particular, have a range of hemodynamic and nonhemodynamic effects that contribute not only to the development of hypertension, but also to renal disease. As a result, therapeutic inhibition of the RAS with angiotensin-converting enzyme inhibitors and/or selective angiotensin II type 1 receptor blockers has been proposed as a key strategy for reducing kidney damage beyond the expected effects one would observe with blood pressure reduction per se. Although the relationship between the RAS and the progression of diabetic renal disease has been known for many decades, recent advances have revealed a more complex paradigm with the discovery of a number of new components. Thus, further understanding of these new components of the renin angiotensin aldosterone system (RAAS), such as the angiotensin type 2 receptor subtype, angiotensin converting enzyme 2, and the recently cloned renin receptor, is likely to have therapeutic implications for disorders such as diabetic nephropathy, where interruption of the RAAS is widely used.

Type 1 diabetes developed in a type 2 diabetic patient with severe insulin resistance

2005 ◽  
Vol 70 (3) ◽  
pp. 298-302 ◽  
Author(s):  
Tadashi Suehiro ◽  
Fumiaki Osaki ◽  
Yukio Ikeda ◽  
Kaoru Arii ◽  
Fumi Nakayama ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Diabetic Patient ◽  
Severe Insulin Resistance ◽  
Type 2 Diabetic
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