scholarly journals Transition in the etiology of liver cirrhosis in Japan: a nationwide survey

2019 ◽  
Vol 55 (3) ◽  
pp. 353-362 ◽  
Author(s):  
Hirayuki Enomoto ◽  
◽  
Yoshiyuki Ueno ◽  
Yoichi Hiasa ◽  
Hiroki Nishikawa ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Viral Hepatitis ◽  
Nationwide Survey ◽  
Newly Diagnosed ◽  
Japan Society ◽  
Real Numbers ◽  
The Real ◽  
Changing Trends ◽  
Notable Increase ◽  
Viral Etiologies

Abstract Background To assess the recent real-world changes in the etiologies of liver cirrhosis (LC) in Japan, we conducted a nationwide survey in the annual meeting of the Japan Society of Hepatology (JSH). Methods We investigated the etiologies of LC patients accumulated from 68 participants in 79 institutions (N = 48,621). We next assessed changing trends in the etiologies of LC by analyzing cases in which the year of diagnosis was available (N = 45,834). We further evaluated the transition in the real number of newly identified LC patients by assessing data from 36 hospitals with complete datasets for 2008–2016 (N = 18,358). Results In the overall data, HCV infection (48.2%) was the leading cause of LC in Japan, and HBV infection (11.5%) was the third-most common cause. Regarding the transition in the etiologies of LC, the contribution of viral hepatitis-related LC dropped from 73.4 to 49.7%. Among the non-viral etiologies, alcoholic-related disease (ALD) and nonalcoholic steatohepatitis (NASH)-related LC showed a notable increase (from 13.7 to 24.9% and from 2.0 to 9.1%, respectively). Regarding the real numbers of newly diagnosed patients from 2008 to 2016, the numbers of patients with viral hepatitis-related LC decreased, while the numbers of patients with non-viral LC increased. Conclusions HCV has remained the main cause of LC in Japan; however, the contribution of viral hepatitis as an etiology of LC is suggested to have been decreasing. In addition, non-viral LC, such as ALD-related LC and NASH-related LC, is suggested to have increased as etiologies of LC in Japan.

scholarly journals The transition in the etiologies of hepatocellular carcinoma-complicated liver cirrhosis in a nationwide survey of Japan

2020 ◽  
Author(s):  
Hirayuki Enomoto ◽  
◽  
Yoshiyuki Ueno ◽  
Yoichi Hiasa ◽  
Hiroki Nishikawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Viral Hepatitis ◽  
Real Number ◽  
Nationwide Survey ◽  
Hcv Infection ◽  
Annual Number ◽  
The Real ◽  
Number Of Patients ◽  
Viral Etiologies

Abstract Background We recently reported the real-world changes in the etiologies of liver cirrhosis (LC) based on nationwide survey data and assessed the etiologies of LC with hepatocellular carcinoma (HCC). Methods Fifty-five participants from 68 institutions provided data on 23,637 patients with HCC-complicated LC. The changing trends in etiologies were assessed. We further analyzed the data from 29 hospitals that provided the annual number of newly identified HCC-complicated LC patients from 2008 to 2016 (N = 9362) without any missing years and assessed the transition in the real number of newly identified HCC-complicated LC cases. Results In the overall cohort, hepatitis C virus (HCV) infection (60.3%) and hepatitis B virus (HBV) infection (12.9%) were the leading and third-most common causes of HCC-complicated LC in Japan, respectively. HCV infection was found to be the leading cause throughout Japan. The rate of viral hepatitis-related HCC decreased from 85.3 to 64.4%. Among non-viral etiologies, notable increases were observed in nonalcoholic steatohepatitis (NASH)-related HCC (from 1.5 to 7.2%) and alcoholic liver disease (ALD)-related HCC (from 8.5 to 18.6%). Regarding the real number of newly diagnosed patients, the number of patients with viral hepatitis-related HCC decreased, while the number of patients with non-viral HCC, particularly NASH-related HCC, increased. Conclusions Viral hepatitis has remained the main cause of HCC in Japan. However, the decrease in viral hepatitis-related HCC, particularly HCV-related HCC highly contributed to the etiological changes. In addition, the increased incidence of non-viral HCC, particularly NASH-related HCC, was involved in the changing etiologies of HCC-complicated LC in Japan.

Real world heart failure epidemiology and outcome: a population-based analysis of 1,990,162 heart failure patients

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
P Leszek ◽  
M Zaleska-Kociecka ◽  
D Was ◽  
K Witczak ◽  
K Bartolik ◽  
...  
Keyword(s):  
Heart Failure ◽  
Real World ◽  
Age Groups ◽  
Developed Countries ◽  
Funding Source ◽  
Newly Diagnosed ◽  
The European Union ◽  
Ministry Of Health ◽  
The Real ◽  
Incidence Prevalence

Abstract Background Heart failure (HF) is the leading cause of death and hospitalization in developed countries. Most of the information about HF is based on selected cohorts, the real epidemiology of HF is scarce. Purpose To assess trends in the real world incidence, prevalence and mortality of all in-and outpatients with HF who presented in public health system in 2009–2018 in Poland. Methods It is a retrospective analysis of 1,990,162 patients who presented with HF in Poland in years 2009–2018. It is a part of nationwide Polish Ministry of Health registry that collects detailed information for the entire Polish population (38,495,659 in 2013) since 2009. Detailed data within the registry were collected since 2013. HF was recorded if HF diagnosis was coded (ICD-10). Results The incidence of HF in Poland fell down from 2013 to reach 127,036 newly diagnosed cases (330 per 100,000 population) in 2018 that equals to 43.6% drop. This decrease was mainly driven by marked reduction in females (p<0.001; Fig. 1A) and HF of ischaemic etiology (HF-IE vs HF-nonIE, Fig. 1B. p<0.001). The HF incidence per 100,000 population decreased across all age groups with the greatest drop in the youngest (Table 1). The prevalence rose by 11.6% to reach 1,242,129 (3233 per 100,000 population) in 2018 with significantly greater increase in females and HF-IE (both p<0.0001, Fig. 1C and D, respectively). The HF prevalence per 100,000 population increased across all age groups except for the 70–79 years old. (Table 1). Mortality increased by 28.5% to reach 142,379 cases (370 per 100,000 population) in 2018. The rise was more pronounced among females (p=0.015, Fig. 1E) and in HF-IE (p<0.001, Fig. 1F). The HF mortality per 100 000 population increased across all age groups, except for the 50–59 subgroup (Table 1). Conclusions Heart failure incidence plummeted in years 2013–2018 in Poland due to drop in newly diagnosed HF-IE. Despite that fact, the prevalence and mortality increased with rising trends in HF-IE. Figure 1. Incidence, prevalence, mortality trends Funding Acknowledgement Type of funding source: Public grant(s) – EU funding. Main funding source(s): The project is co-financed by the European Union from the European Social Fund under the Operational Programme Knowledge Education Development and it is being carried out by the Analyses and Strategies Department of the Polish Ministry of Health

Shuffling of Linear Orders

1995 ◽  
Vol 38 (2) ◽  
pp. 223-229
Author(s):  
John Lindsay Orr
Keyword(s):  
Ordered Set ◽  
Linear Orders ◽  
Real Numbers ◽  
The Real ◽  
Linearly Ordered Set

AbstractA linearly ordered set A is said to shuffle into another linearly ordered set B if there is an order preserving surjection A —> B such that the preimage of each member of a cofinite subset of B has an arbitrary pre-defined finite cardinality. We show that every countable linearly ordered set shuffles into itself. This leads to consequences on transformations of subsets of the real numbers by order preserving maps.

scholarly journals ALTERATIONS IN SERUM TRANSAMINASE ACTIVITIES IN VIRAL HEPATITIS AND LIVER CIRRHOSIS

1962 ◽  
Vol 51 (3) ◽  
pp. 227-236
Author(s):  
Tadashi AMIOKA ◽  
Kazuhisa TAKETA ◽  
Ichiro UJIHIRA ◽  
Yasuhiro TAKITANI
Keyword(s):  
Liver Cirrhosis ◽  
Viral Hepatitis ◽  
Serum Transaminase

scholarly journals A question of van den Dries and a theorem of Lipshitz and Robinson; Not everything is standard

2007 ◽  
Vol 72 (1) ◽  
pp. 119-122 ◽  
Author(s):  
Ehud Hrushovski ◽  
Ya'acov Peterzil
Keyword(s):  
Real Numbers ◽  
The Real ◽  
First Order ◽  
Real Closed Fields ◽  
Minimal Structure ◽  
Closed Fields ◽  
New Construction ◽  
The Relationship

AbstractWe use a new construction of an o-minimal structure, due to Lipshitz and Robinson, to answer a question of van den Dries regarding the relationship between arbitrary o-minimal expansions of real closed fields and structures over the real numbers. We write a first order sentence which is true in the Lipshitz-Robinson structure but fails in any possible interpretation over the field of real numbers.

Kawasaki Disease Continues to Increase in Japan

PEDIATRICS ◽  
1979 ◽  
Vol 64 (3) ◽  
pp. 386-386
Author(s):  
I. Shigematsu ◽  
S. Shibata ◽  
H. Tamashiro ◽  
T. Kawasaki ◽  
S. Kusakawa
Keyword(s):  
Kawasaki Disease ◽  
Nationwide Survey ◽  
Newly Diagnosed ◽  
Research Committee

Mucocutaneous lymphnode syndrome (MCLS) or Kawasaki disease was reported first by Kawasaki in Japan in 1967.1 Cases of MCLS have been reported in many countries, since it was reported in Pediatrics in 1974.2 By the end of 1976, about 12,000 cases were collected and registered throughout Japan by the MCLS Research Committee which was organized in 1970. The Committee is now conducting the fifth nationwide survey of all pediatric departments of hospitals with more than 100 beds (1,688 hospitals) in order to register cases of MCLS newly diagnosed during 1977-1978.

Portal vein thrombosis as a complication of coronavirus infection against the background of chronic viral hepatitis

2021 ◽  
Vol 2 (88) ◽  
pp. 66-70
Author(s):  
A.V. Kuznetsova ◽  
◽  
A.V. Ivolgina ◽  
Ye.V. Dubotolkina ◽  
T.Ye. Makarova ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Portal Vein ◽  
Viral Hepatitis ◽  
Abdominal Ultrasound ◽  
Chronic Viral Hepatitis ◽  
Outpatient Basis ◽  
Vein Thrombosis ◽  
Viral Hepatitis C ◽  
Coronavirus Infection

The article presents an extract from an outpatient case history card of a 47-year-old patient observed at the Central Hospital for Chronic Hepatitis C. In 2017, he received a course of therapy for this disease (Pegasis in combination with ribavirin). A sustained virological response (SVR) has been achieved. According to elastometry data dated 12/13/2017 – the degree of fibrosis F4 Metavir, 13.1 KPa. In January 2021, he suffered a coronavirus infection (according to the CT scan of the lungs, the lesion was 20 %). The disease proceeded against the background of chronic viral hepatitis C complicated by liver cirrhosis. He was treated symptomatically on an outpatient basis. He did not receive anticoagulant therapy. In February 2021, abdominal ultrasound (ABP) revealed a thrombus in the portal vein. The presence of a thrombus in the portal vein contributes to the further progression of liver cirrhosis

scholarly journals Aflatoxin Exposure and Viral Hepatitis in the Etiology of Liver Cirrhosis in The Gambia, West Africa

2008 ◽  
Vol 116 (11) ◽  
pp. 1553-1557 ◽  
Author(s):  
Mark H. Kuniholm ◽  
Olufunmilayo A. Lesi ◽  
Maimuna Mendy ◽  
Aliu O. Akano ◽  
Omar Sam ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
West Africa ◽  
Viral Hepatitis ◽  
The Gambia
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