Effect of aqueous extract of Hibiscus sabdariffa on some biochemical parameters in alloxan-induced diabetic rats

2014 ◽  
Vol 23 (6) ◽  
pp. 1675-1680 ◽  
Author(s):  
Patrick Emeka Aba ◽  
Chioma Uchenna Nwaigwe ◽  
Flora Ogbonne Okwuagwu ◽  
Samuel Chukwuneke Udem ◽  
Isaac Uzoma Asuzu
2017 ◽  
Vol 12 (2) ◽  
pp. 44-48
Author(s):  
Wakawa Henry Yusufu ◽  
Oluwayemisi Tanimowo ◽  
Sa`adatu Aliyu Abubakar ◽  
Fasihuddin Badruddin Ahmad

2020 ◽  
Vol 51 (1) ◽  
pp. 103-113
Author(s):  
Basiru Olaitan Ajiboye ◽  
Babatunji Emmanuel Oyinloye ◽  
Precious Ekong Essien ◽  
Sunday Amos Onikanni ◽  
Oluwafemi Adeleke Ojo ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Shou-Chieh Wang ◽  
Shiow-Fen Lee ◽  
Chau-Jong Wang ◽  
Chao-Hsin Lee ◽  
Wen-Chin Lee ◽  
...  

Several studies point out that oxidative stress maybe a major culprit in diabetic nephropathy. Aqueous extract ofHibiscus sabdariffaL. (HSE) has been demonstrated as having beneficial effects on anti-oxidation and lipid-lowering in experimental studies. This study aimed at investigating the effects ofHibiscus sabdariffaL. on diabetic nephropathy in streptozotocin induced type 1 diabetic rats. Our results show that HSE is capable of reducing lipid peroxidation, increasing catalase and glutathione activities significantly in diabetic kidney, and decreasing the plasma levels of triglyceride, low-density lipoprotein (LDL) and increasing high-density lipoprotein (HDL) value. In histological examination, HSE improves hyperglycemia-caused osmotic diuresis in renal proximal convoluted tubules (defined as hydropic change) in diabetic rats. The study also reveals that up-regulation of Akt/Bad/14-3-3γand NF-κB-mediated transcription might be involved. In conclusion, our results show that HSE possesses the potential effects to ameliorate diabetic nephropathy via improving oxidative status and regulating Akt/Bad/14-3-3γsignaling.


2014 ◽  
Vol 12 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Nor Malia Abd Warif ◽  
Asyraf Akmal Ayob ◽  
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Siti Balkis Budin ◽  
Satirah Zainalabidin ◽  
...  

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
NM De Gouveia ◽  
IB Moraes ◽  
RMF Sousa ◽  
MB Neto ◽  
AV Mundim ◽  
...  

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