Genomic ancestry as a risk factor for diabetic retinopathy in patients with type 1 diabetes from an admixed population: a nested case–control study in Brazil

2020 ◽  
Vol 57 (8) ◽  
pp. 937-945
Author(s):  
Deborah Conte Santos ◽  
Laura Gomes Nunes de Melo ◽  
Marcela Haas Pizarro ◽  
Bianca S. V. Barros ◽  
Carlos Antonio Negrato ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Risk Factor ◽  
Case Control Study ◽  
Case Control ◽  
Admixed Population ◽  
Nested Case Control ◽  
Control Study

scholarly journals Human Leukocyte Antigens class II (HLA II) gene profile from an admixed population of patients with type 1 diabetes with severe diabetic retinopathy: a nested case-control study in Brazil

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Deborah Conte Santos ◽  
Luís Cristóvão Porto ◽  
Marcela Haas Pizarro ◽  
Laura Gomes Nunes de Melo ◽  
Dayse A. Silva ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Case Control Study ◽  
Case Control ◽  
P Value ◽  
Admixed Population ◽  
Nested Case Control ◽  
Control Study

Abstract Background Although the well-established role of the HLA genes on the predisposition of type 1 diabetes (T1D), its contribution to the development and progression of diabetic retinopathy is still unclear, especially in admixed populations. We aimed to study the relationship between HLA alleles and severe diabetic retinopathy in a highly admixed population of T1D patients. Methods This was a nested case-control study based on a cross-sectional, nationwide survey conducted in Brazil. We included 117 patients with severe diabetic retinopathy and 117 random controls composed of T1D patients without retinopathy, matched for diabetes duration. HLA-class II genes (HLA-DRB1, -DQA1, and -DQB1) were genotyped using the SSO and NGS methods. Results Haplotypes HLA-DRB1*04:05 ~ DQA1*03:01 g ~ DQB1*03:02 (OR 1.75, CI 0.97–3.16, p value 0.058) and HLA-DRB1*13:02 ~ DQA1*01:02 ~ DQB1*06:04 (OR 5.18, CI 1.12–23.09, p value 0.019) were more prevalent on the severe DR group but they did not present statistically difference after Bonferroni correction. The most frequent haplotype on both groups was HLA-DRB1*03:01 ~ DQA1*05:01 g ~ DQB1*02:01 (29.6% on severe DR and 33.33% on the control group). Conclusions Our study showed no influence of HLA genes on the development of DR. Further longitudinal data is needed to better understand the role of genetic factors on this multifactorial significant microvascular complication.

scholarly journals Diabetic Retinopathy May Indicate an Increased Risk of Cardiovascular Disease in Patients With Type 1 Diabetes—A Nested Case-Control Study in Brazil

2019 ◽  
Vol 10 ◽  
Author(s):  
Laura Gomes Nunes Melo ◽  
Paulo Henrique Morales ◽  
Karla Rezende Guerra Drummond ◽  
Deborah Conte Santos ◽  
Marcela Haas Pizarro ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
Nested Case Control ◽  
Control Study

scholarly journals Lower prediagnostic serum 25‐hydroxyvitamin D concentration is associated with increased incidence of type 1 diabetes in the U. S. military: a nested case‐control study

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Edward Doerr Gorham ◽  
Cedric Frank Garland ◽  
Alina Burgi ◽  
Sharif Burgette Mohr ◽  
Kenneth Zeng ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Nested Case Control ◽  
Control Study

Rotavirus immunization and type 1 diabetes mellitus: A nested case–control study

2014 ◽  
Vol 6 (4) ◽  
pp. 147-149
Author(s):  
Gabriel Chodick ◽  
Moran Almog ◽  
Shai Ashkenazi ◽  
Tal Sella
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study
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