Patterns of changes in fasting plasma glucose, hemoglobin A1c and the area under the curve during oral glucose tolerance tests in prediabetic subjects: results from a 16-year prospective cohort study among first-degree relatives of type 2 diabetic patients

Author(s):  
Shahla Safari ◽  
Masoud Amini ◽  
Ashraf Aminorroaya ◽  
Awat Feizi
2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
V. T. T. Huyen ◽  
D. V. Phan ◽  
P. Thang ◽  
P. T. Ky ◽  
N. K. Hoa ◽  
...  

Aims.To investigate the antidiabetic effect of the traditional Vietnamese herbGynostemma pentaphyllum(GP) together with sulfonylurea (SU) in 25 drug-naïve type 2 diabetic patients.Methods.After 4-week treatment with gliclazide (SU), 30 mg daily, all patients were randomly assigned into 2 groups to add on GP extract or placebo extract, 6 g daily, during eight weeks.Results.After 4-week SU treatment, fasting plasma glucose (FPG) and HbA1Cdecreased significantly (P<0.001). FPG was further reduced after add-on therapy with 2.9 ± 1.7 and 0.9 ± 0.6 mmol/L in the GP and placebo groups, respectively (P<0.001). Therapy with GP extract also reduced 30- and 120-minute oral glucose tolerance test postload values. HbA1Clevels decreased approximately 2% units in the GP group compared to 0.7% unit in the placebo group (P<0.001).Conclusion.GP extract in addition to SU offers an alternative to addition of other oral medication to treat type 2 diabetic patients.


2012 ◽  
Vol 27 (10) ◽  
pp. 1196 ◽  
Author(s):  
Seong-Woo Choi ◽  
Young-Hoon Lee ◽  
Sun-Seog Kweon ◽  
Hye-rim Song ◽  
Hye-Ran Ahn ◽  
...  

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