Antidiabetic Effects of Add-OnGynostemma pentaphyllumExtract Therapy with Sulfonylureas in Type 2 Diabetic Patients

Aims.To investigate the antidiabetic effect of the traditional Vietnamese herbGynostemma pentaphyllum(GP) together with sulfonylurea (SU) in 25 drug-naïve type 2 diabetic patients.Methods.After 4-week treatment with gliclazide (SU), 30 mg daily, all patients were randomly assigned into 2 groups to add on GP extract or placebo extract, 6 g daily, during eight weeks.Results.After 4-week SU treatment, fasting plasma glucose (FPG) and HbA1Cdecreased significantly (P<0.001). FPG was further reduced after add-on therapy with 2.9 ± 1.7 and 0.9 ± 0.6 mmol/L in the GP and placebo groups, respectively (P<0.001). Therapy with GP extract also reduced 30- and 120-minute oral glucose tolerance test postload values. HbA1Clevels decreased approximately 2% units in the GP group compared to 0.7% unit in the placebo group (P<0.001).Conclusion.GP extract in addition to SU offers an alternative to addition of other oral medication to treat type 2 diabetic patients.

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Assessment of insulin sensitivity and insulin secretion from the oral glucose tolerance test in nonobese Japanese type 2 diabetic patients: comparison with minimal-model approach

Diabetes Care ◽

10.2337/diacare.23.9.1439 ◽

2000 ◽

Vol 23 (9) ◽

pp. 1439-1440 ◽

Cited By ~ 9

Author(s):

A. Taniguchi ◽

S. Nagasaka ◽

M. Fukushima ◽

M. Sakai ◽

I. Nagata ◽

...

Keyword(s):

Insulin Secretion ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Oral Glucose ◽

Diabetic Patients ◽

Oral Glucose Tolerance ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic ◽

Model Approach

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Identification of the Mechanism of Action of a Glucokinase Activator From Oral Glucose Tolerance Test Data in Type 2 Diabetic Patients Based on an Integrated Glucose-Insulin Model

The Journal of Clinical Pharmacology ◽

10.1177/0091270011422231 ◽

2012 ◽

Vol 52 (12) ◽

pp. 1861-1871 ◽

Cited By ~ 16

Author(s):

Petra M. Jauslin ◽

Mats O. Karlsson ◽

Nicolas Frey

Keyword(s):

Glucose Tolerance ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Oral Glucose ◽

Diabetic Patients ◽

Oral Glucose Tolerance ◽

Type 2 Diabetic Patients ◽

Glucokinase Activator ◽

Type 2 Diabetic

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Patterns of changes in fasting plasma glucose, hemoglobin A1c and the area under the curve during oral glucose tolerance tests in prediabetic subjects: results from a 16-year prospective cohort study among first-degree relatives of type 2 diabetic patients

Acta Diabetologica ◽

10.1007/s00592-020-01622-5 ◽

2020 ◽

Author(s):

Shahla Safari ◽

Masoud Amini ◽

Ashraf Aminorroaya ◽

Awat Feizi

Keyword(s):

Hemoglobin A1c ◽

Area Under The Curve ◽

Oral Glucose ◽

Diabetic Patients ◽

Oral Glucose Tolerance ◽

Type 2 Diabetic Patients ◽

Oral Glucose Tolerance Tests ◽

Glucose Tolerance Tests ◽

Type 2 Diabetic

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Effect of eicosapentaenoic acid ethyl ester v. oleic acid-rich safflower oil on insulin resistance in type 2 diabetic model rats with hypertriacylglycerolaemi

British Journal Of Nutrition ◽

10.1079/bjn2001496 ◽

2002 ◽

Vol 87 (2) ◽

pp. 157-162 ◽

Cited By ~ 38

Author(s):

Asako Minami ◽

Noriko Ishimura ◽

Sadaichi Sakamoto ◽

Eiko Takishita ◽

Kazuaki Mawatari ◽

...

Keyword(s):

Insulin Resistance ◽

Oleic Acid ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Abdominal Fat ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Oletf Rats ◽

Type 2 Diabetic

The purpose of the present study was to test whether hyperlipidaemia and insulin resistance in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats can be improved by dietary supplementation with purified eicosapentaenoic acid (EPA) or oleic acid (OA). Male OLETF rats were fed powdered chow (510 g fat/kg) alone (n 8) or chow supplemented with 1·0 g EPA- (n 8) or OA- (n 8) rich oil/kg per d from 5 weeks until 30 weeks of age. An oral glucose tolerance test and hyperinsulinaemic euglycaemic clamp was performed at 25 and 30 weeks of age. EPA supplementation resulted in significantly (P<0.05) reduced plasma lipids, hepatic triacylglycerols, and abdominal fat deposits, and more efficient in vivo glucose disposal compared with OA supplementation and no supplementation. OA supplementation was associated with significantly increased insulin response to oral glucose compared with EPA supplementation and no supplementation. Inverse correlation was noted between glucose uptake and plasma triacylglycerol levels (r -0·86, P<0·001) and abdominal fat volume (r -0·80, P<0·001). The result of oral glucose tolerance test study showed that the rats fed EPA tended to improve glucose intolerance, although this was not statistically significant. Levels of plasma insulin at 60 min after glucose was significantly increased in rats fed OA compared with the other two groups. The results indicate that long-term feeding of EPA might be effective in preventing insulin resistance in diabetes-prone rats, at least in part, due to improving hypertriacylglycerolaemia.

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Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione

Diabetes Obesity and Metabolism ◽

10.1111/j.1463-1326.2005.00568.x ◽

2006 ◽

Vol 8 (5) ◽

pp. 561-567 ◽

Cited By ~ 13

Author(s):

A. Kautzky-Willer ◽

A. Tura ◽

C. Winzer ◽

O. F. Wagner ◽

B. Ludvik ◽

...

Keyword(s):

Insulin Sensitivity ◽

Glucose Metabolism ◽

Glucose Tolerance ◽

Oral Glucose Tolerance Test ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Type 2 Diabetic

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Conformance of the diagnostic criteria for diabetes mellitus estimated from the results of the oral glucose tolerance testsand glycated hemoglobin (HbA1c) level

Problems of Endocrinology ◽

10.14341/probl201460136-38 ◽

2014 ◽

Vol 60 (1) ◽

pp. 36-38

Author(s):

E A Shestakova

Keyword(s):

Diabetes Mellitus ◽

Glucose Tolerance ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Oral Glucose ◽

Diabetic Patients ◽

Oral Glucose Tolerance ◽

Study Population ◽

Hba1c Measurement

The study population of 127 patients with type 2 diabetes mellitus (T2DM) risk factors underwent oral glucose tolerance test (OGTT) and HbA1c measurement for diagnostic reasons. HbA1c revealed less diabetic patients than OGTT (31% vs 43%). HbA1c >7% and OGTT were similar in confirming diabetes, but HbA1c <7% suggests the need for OGTT performance to validate the diagnosis.

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