scholarly journals Strong cytoplasmic expression of NF-κB/p65 correlates with a good prognosis in patients with triple-negative breast cancer

Surgery Today ◽  
2015 ◽  
Vol 46 (7) ◽  
pp. 843-851 ◽  
Author(s):  
Motoi Baba ◽  
Masato Takahashi ◽  
Katsushige Yamashiro ◽  
Hideki Yokoo ◽  
Moto Fukai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Good Prognosis ◽  
Cytoplasmic Expression

scholarly journals Prognostic Role of Androgen Receptor in Triple Negative Breast Cancer: A Multi-Institutional Study

Cancers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 995 ◽  
Author(s):  
Shristi Bhattarai ◽  
Sergey Klimov ◽  
Karuna Mittal ◽  
Uma Krishnamurti ◽  
Xiaoxian Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Molecular Subtype ◽  
Good Prognosis ◽  
Prognostic Role ◽  
Primary Tumors ◽  
Total N

Background: The androgen receptor (AR) has emerged as a potential therapeutic target for AR-positive triple-negative breast cancer (TNBC). However, conflicting reports regarding AR’s prognostic role in TNBC are putting its usefulness in question. Some studies conclude that AR positivity indicates a good prognosis in TNBC, whereas others suggest the opposite, and some show that AR status has no significant bearing on the patients’ prognosis. Methods: We evaluated the prognostic value of AR in resected primary tumors from TNBC patients from six international cohorts {US (n = 420), UK (n = 239), Norway (n = 104), Ireland (n = 222), Nigeria (n = 180), and India (n = 242); total n = 1407}. All TNBC samples were stained with the same anti-AR antibody using the same immunohistochemistry protocol, and samples with ≥1% of AR-positive nuclei were deemed AR-positive TNBCs. Results: AR status shows population-specific patterns of association with patients’ overall survival after controlling for age, grade, population, and chemotherapy. We found AR-positive status to be a marker of good prognosis in US and Nigerian cohorts, a marker of poor prognosis in Norway, Ireland and Indian cohorts, and neutral in UK cohort. Conclusion: AR status, on its own, is not a reliable prognostic marker. More research to investigate molecular subtype composition among the different cohorts is warranted.

scholarly journals Adenoid cystic carcinoma: triple negative breast cancer with good prognosis

2016 ◽  
pp. bcr2015213704 ◽  
Author(s):  
Daniel Romeira ◽  
Débora Cardoso ◽  
Helena Miranda ◽  
Ana Martins
Keyword(s):  
Breast Cancer ◽  
Adenoid Cystic Carcinoma ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Good Prognosis ◽  
Adenoid Cystic

scholarly journals 1151 Update on triple-negative breast cancer: the good prognosis

2021 ◽  
Author(s):  
S Sakhri ◽  
K Hamza ◽  
S Kamoun ◽  
Y Houcine ◽  
T Karima ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Good Prognosis

scholarly journals Exploring specific prognostic biomarkers in triple-negative breast cancer

2019 ◽  
Vol 10 (11) ◽  
Author(s):  
Chang Bao ◽  
Yunkun Lu ◽  
Jishun Chen ◽  
Danni Chen ◽  
Weiyang Lou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Target Genes ◽  
Triple Negative ◽  
Therapeutic Targets ◽  
Good Prognosis ◽  
The Cancer Genome Atlas ◽  
Prognostic Biomarkers ◽  
Luciferase Reporter ◽  
Hub Genes

Abstract Lacking of both prognostic biomarkers and therapeutic targets, triple-negative breast cancer (TNBC) underscores pivotal needs to uncover novel biomarkers and viable therapies. MicroRNAs have broad biological functions in cancers and may serve as ideal biomarkers. In this study, by data mining of the Cancer Genome Atlas database, we screened out 4 differentially-expressed microRNAs (DEmiRNAs) between TNBC and normal samples: miR-135b-5p, miR-9-3p, miR-135b-3p and miR-455-5p. They were specially correlated with the prognosis of TNBC but not non-TNBC. The weighted correlation network analysis (WGCNA) for potential target genes of 3 good prognosis-related DEmiRNAs (miR-135b-5p, miR-9-3p, miR-135b-3p) identified 4 hub genes with highly positive correlation with TNBC subtype: FOXC1, BCL11A, FAM171A1 and RGMA. The targeting relationships between miR-9-3p and FOXC1/FAM171A1, miR-135b-3p and RGMA were validated by dual-luciferase reporter assays. Importantly, the regulatory functions of 4 DEmiRNAs and 3 verified target genes on cell proliferation and migration were explored in TNBC cell lines. In conclusion, we shed lights on these 4 DEmiRNAs (miR-135b-5p, miR-9-3p, miR-135b-3p, miR-455-5p) and 3 hub genes (FOXC1, FAM171A1, RGMA) as specific prognostic biomarkers and promising therapeutic targets for TNBC.

Expression of NY-ESO-1 in Triple-Negative Breast Cancer Is Associated with Tumor-Infiltrating Lymphocytes and a Good Prognosis

Oncology ◽  
2015 ◽  
Vol 89 (6) ◽  
pp. 337-344 ◽  
Author(s):  
Hee Jin Lee ◽  
Joo Young Kim ◽  
In Hye Song ◽  
In Ah Park ◽  
Jong Han Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Tumor Infiltrating Lymphocytes ◽  
Good Prognosis ◽  
Infiltrating Lymphocytes

scholarly journals Triple-negative breast cancer in children: a case report

2021 ◽  
Author(s):  
Lexiang SHI ◽  
Chengtao Chi ◽  
Yinan Zhang ◽  
Zhongwen Sun ◽  
Wenxian Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Treatment Options ◽  
Growth Factor Receptor ◽  
Good Prognosis ◽  
Her 2 ◽  
Epidermal Growth ◽  
Cancer In Children

Abstract Background Triple-negative breast cancer (TNBC) is often considered a breast tumor with a poor prognosis that lacks or decreases the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2). It tends to occur in middle-aged and older women, and cases of TNBC in children are rarely reported. Methods We report a case of basal-like TNBC in a child at our hospital and review the related literature. Results Based on the patient's condition we performed a local mass excision, and despite the postoperative pathological diagnosis of TNBC, this case of basic TNBC had a good prognosis and was very different from conventional basic TNBC in many ways. Conclusions Although secretory breast cancer is a subtype of basal-like TNBC, it has its peculiarities and is completely different from basal-like TNBC. There is a need to raise awareness of the disease, select individualized treatment options, and prevent medical errors.

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