A sandwich-type electrochemical immunosensor based on Au-rGO composite for CA15-3 tumor marker detection

2021 ◽  
Vol 189 (1) ◽  
Author(s):  
Thiago S. Martins ◽  
José L. Bott-Neto ◽  
Osvaldo N. Oliveira ◽  
Sergio A. S. Machado
Keyword(s):  
Tumor Marker ◽  
Electrochemical Immunosensor ◽  
Sandwich Type ◽  
Marker Detection

Electrochemical Immunosensors Based on Nanostructured Materials for Sensing of Prostate-Specific Antigen: A Review

2020 ◽  
Vol 28 ◽  
Author(s):  
Hayati Filik ◽  
Asiye Aslıhan Avan ◽  
Mustafa Özyürek
Keyword(s):  
Prostate Specific Antigen ◽  
Nanostructured Materials ◽  
Specific Antigen ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Electrochemical Immunosensors ◽  
Metal Metal ◽  
Different Types ◽  
Sandwich Type ◽  
Carbon Based Nanomaterials

: The prostate-specific antigen (PSA) has been considered a crucial serological marker for distinguishing prostate based cancer. This surveys recent progress in the construction of nanomaterial-based electrochemical immunosensors for a PSA. This review (from 2015 to 2020) reports the latest progress in PSA sensing based on the employ of different types of nanostructured materials. The most popular used nanostructured materials are metal, metal oxide, carbon-based nanomaterials, and their hybrid architectures utilized for distinct amplification protocols. In this review, the electrochemical immunosensors for prostate-specific antigen sensing are classified into three categories such as sandwich type@labeled, label free@nonlabeled and aptamer-based electrochemical immunosensor.

Tumor Marker Detection by Aptamer-Functionalized Graphene Oxide

2013 ◽  
Vol 17 (2) ◽  
pp. 132-136 ◽  
Author(s):  
Ming-Yu Lin ◽  
Yen-Pei Lu ◽  
Alexandru Grumezescu ◽  
Fu Han Ho ◽  
Ying-Hsien Kao ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Tumor Marker ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Marker Detection

Fluorescence immunosensor based on p-acid-encapsulated silica nanoparticles for tumor marker detection

The Analyst ◽  
2012 ◽  
Vol 137 (12) ◽  
pp. 2834 ◽  
Author(s):  
Mei Yan ◽  
Shenguang Ge ◽  
Weiqiang Gao ◽  
Chengchao Chu ◽  
Jinghua Yu ◽  
...  
Keyword(s):  
Tumor Marker ◽  
Silica Nanoparticles ◽  
Marker Detection

scholarly journals Sandwich Electrochemical Immunosensor for Early Detection of Tuberculosis Based on Graphene/Polyaniline-Modified Screen-Printed Gold Electrode

Sensors ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 3926 ◽  
Author(s):  
Umi Mohd Azmi ◽  
Nor Yusof ◽  
Norzila Kusnin ◽  
Jaafar Abdullah ◽  
Siti Suraiya ◽  
...  
Keyword(s):  
Gold Electrode ◽  
Differential Pulse ◽  
Sample Volume ◽  
Electrochemical Immunosensor ◽  
X Ray ◽  
Sandwich Type ◽  
Pulse Voltammetry ◽  
Culture Filtrate Protein ◽  
Cast Technique ◽  
Screen Printed

A rapid and sensitive sandwich electrochemical immunosensor was developed based on the fabrication of the graphene/polyaniline (GP/PANI) nanocomposite onto screen-printed gold electrode (SPGE) for detection of tuberculosis biomarker 10-kDa culture filtrate protein (CFP10). The prepared GP/PANI nanocomposite was characterized using Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FESEM). The chemical bonding and morphology of GP/PANI-modified SPGE were studied by Raman spectroscopy and FESEM coupled with energy dispersive X-ray spectroscopy, respectively. From both studies, it clearly showed that GP/PANI was successfully coated onto SPGE through drop cast technique. Cyclic voltammetry was used to study the electrochemical properties of the modified electrode. The effective surface area for GP/PANI-modified SPGE was enhanced about five times compared with bare SPGE. Differential pulse voltammetry was used to detect the CFP10 antigen. The GP/PANI-modified SPGE that was fortified with sandwich type immunosensor exhibited a wide linear range (20–100 ng/mL) with a low detection limit of 15 ng/mL. This proposed electrochemical immunosensor is sensitive, low sample volume, rapid and disposable, which is suitable for tuberculosis detection in real samples.

Sign in / Sign up

Export Citation Format

Share Document