The role of the defective interfering particle DI9c in mucosal disease in cattle

Agger nasi cells contribute to nasofrontal duct (NFD) obstruction and chronic frontal sinus disease. To investigate this relationship, we conducted a review of the surgical outcome and computed tomographic imaging in 26 patients with chronic frontal sinusitis. Coronal and sagittal images were used to delineate the anatomic variability and mucosal disease in the NFD and frontal sinus region. Data from coronal and sagittal images were compared. The results were also correlated with the outcome of frontal sinus surgery in patients with a clinical history of chronic frontal sinus disease. Our data suggest that agger nasi cell pneumatization with narrowing of the frontal sinus outflow tract is a significant cause of persistent frontoethmoid pain and chronic frontal sinusitis. Sagittal reformatted images are more capable than coronal images of demonstrating agger nasi cell encroachment on the NFD, as well as NFD mucosal disease. Endoscopic frontal sinusotomy is an effective treatment for chronic frontal sinus disease.

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The Anatomic Relevance of the Haller Cell in Sinusitis

American Journal of Rhinology ◽

10.2500/105065897781751910 ◽

1997 ◽

Vol 11 (3) ◽

pp. 219-224 ◽

Cited By ~ 26

Author(s):

Sarah A. Stackpole ◽

David R. Edelstein

Keyword(s):

Maxillary Antrum ◽

Causative Factor ◽

Small Cells ◽

Ct Scans ◽

Etiologic Factor ◽

Mucosal Disease ◽

Ostiomeatal Complex ◽

Mucosal Thickening ◽

Radiologic Evidence

In current theories of sinusitis, obstruction at the ostiomeatal complex leads to localized inflammation and infection. Haller cells, an extension of ethmoid pneumatization along the maxillary antrum roof, have also been suggested as a causative factor in sinusitis because of their ability to cause narrowing of the infundibulum. Coronal CT scans were reviewed in 154 patients to evaluate the role of Haller cells in sinusitis. Haller cells were present in 34% of patients. The cells were graded as small, medium, or large, and correlated with radiologic evidence of sinusitis (e.g., mucosal thickening or opacification). A statistically significant increase in maxillary sinus mucosal disease was noted in patients with medium or large Haller cells (45.8%) versus those with small cells (28.9%, p < 0.05). Thus obstructive medium and large Haller cells may be an etiologic factor in sinusitis.

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Stress-related mucosal disease: Incidence of bleeding and the role of omeprazole in its prophylaxis

European Journal of Internal Medicine ◽

10.1016/j.ejim.2010.06.010 ◽

2010 ◽

Vol 21 (5) ◽

pp. 386-388 ◽

Cited By ~ 12

Author(s):

Marta C. Amaral ◽

Catarina Favas ◽

J. Delgado Alves ◽

Nuno Riso ◽

M. Vaz Riscado

Keyword(s):

Disease Incidence ◽

Mucosal Disease

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Pathophysiological role of ion channels and transporters in gastrointestinal mucosal diseases

Cellular and Molecular Life Sciences ◽

10.1007/s00018-021-04011-5 ◽

2021 ◽

Author(s):

Zilin Deng ◽

Yingying Zhao ◽

Zhiyuan Ma ◽

Minglin Zhang ◽

Hu Wang ◽

...

Keyword(s):

Ion Channels ◽

Mucosal Blood Flow ◽

Mucosal Barrier ◽

Acid Base Balance ◽

Mucosal Disease ◽

Pathophysiological Role ◽

Base Balance ◽

Inflammatory Bowel ◽

The Relationship

AbstractThe incidence of gastrointestinal (GI) mucosal diseases, including various types of gastritis, ulcers, inflammatory bowel disease and GI cancer, is increasing. Therefore, it is necessary to identify new therapeutic targets. Ion channels/transporters are located on cell membranes, and tight junctions (TJs) affect acid–base balance, the mucus layer, permeability, the microbiota and mucosal blood flow, which are essential for maintaining GI mucosal integrity. As ion channel/transporter dysfunction results in various GI mucosal diseases, this review focuses on understanding the contribution of ion channels/transporters to protecting the GI mucosal barrier and the relationship between GI mucosal disease and ion channels/transporters, including Cl−/HCO3− exchangers, Cl− channels, aquaporins, Na+/H+ exchangers, and K+ channels. Here, we provide novel prospects for the treatment of GI mucosal diseases.

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New Approaches to Candida and Oral Mycotic Infections

Advances in Dental Research ◽

10.1177/0022034511400912 ◽

2011 ◽

Vol 23 (1) ◽

pp. 152-158 ◽

Cited By ~ 4

Author(s):

M. McCullough ◽

L.L. Patton ◽

M. Coogan ◽

P.L. Fidel ◽

M. Komesu ◽

...

Keyword(s):

Hiv Transmission ◽

Disease Process ◽

Fungal Disease ◽

Poor Countries ◽

Mucosal Disease ◽

Oral Candidosis ◽

Oral Biofilms ◽

Neonatal Nutrition ◽

Topical Medications

This workshop reviewed aspects of the following: oral fungal disease in HIV-infected patients and the predictive value of oral mucosal disease in HIV progression; the role of the oral biofilms in mucosal disease; microbial virulence factors and the pseudomembranous oral mucosal disease process; the role that oral mucosal disease may have in HIV transmission; and the available topical antifungal treatment. This article summarizes the ensuing discussions and raises pertinent problems and potential research directions associated with oral fungal disease in HIV-infected patients, including the frequency of oral candidosis, the role of the intraoral biofilm in the development of oral mucosal disease, and host-pathogen interactions, as well as the development of the fetal oral mucosa, neonatal nutrition, and the role of oral candidosis in this setting. Finally, discussions are summarized on the use of inexpensive effective antifungal mouthwashes in resource-poor countries, the potential stigmata that may be associated with their use, as well as novel topical medications that may have clinical applicability in managing oral candidal infections in HIV-infected patients.

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Role of Osteitis in Chronic Rhinosinusitis: A Predictive Marker of Disease Severity?

Bengal Journal of Otolaryngology and Head Neck Surgery ◽

10.47210/bjohns.2021.v29i2.431 ◽

2021 ◽

Vol 29 (2) ◽

pp. 125-132

Author(s):

Neelima Gupta ◽

Ankit Parasher ◽

Rohit Bhardwaj ◽

Sonal Sharma ◽

Shuchi Bhatt ◽

...

Keyword(s):

Chronic Rhinosinusitis ◽

Treatment Plan ◽

Surrogate Marker ◽

Hounsfield Unit ◽

Predictive Marker ◽

Disease Outcome ◽

Bone Thickness ◽

Severity Of Disease ◽

Mucosal Disease

Introduction Chronic rhinosinusitis (CRS) not only affects the overlying mucosa but also involve the underlying sinus bone termed as osteitis. The role of osteitic bone in severity and persistence of disease has received little attention. Thus understanding of this can help in formulating better treatment plan for CRS. We conceived this study with an aim to assess correlation of osteitis with severity of disease and short term disease outcome by examining the various parameters concerned with CRS. Material and Methods This prospective cohort study included 40 participants as clinically diagnosed CRS cases and 20 participants as controls. Various pre and post-operative parameters concerning CRS were assessed like pre and post-operative Sino-Nasal Outcome Test (SNOT) 20 symptom score, Lund-Kennedy endoscopy and Lund Mackay CT scores, bone density / Hounsfield unit (HU), radiological bone thickness and histopathological mucosal and bone grading. Correlation between osteitis and all these parameters were analyzed. Results Osteitis / bone grade was found to have statistically significant, moderate and positive correlation with the preoperative Lund and Mackay CT score and mucosal grade. The osteitis / bone grade was found to be weakly and positively correlated to the Lund and Kennedy score and weakly but negatively correlated to change in SNOT- 20 values (both statistically insignificant). Conclusion There are high chances of harbouring severe osteitis underneath high grade mucosal disease in CRS. Preoperative Lund and Mackay CT score can serve as a surrogate marker for osteitis. Symptomatic severity of disease does not correlate with osteitis. Osteitis affects disease outcome negatively.

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