scholarly journals Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease: A paradigm shift from acid to bacteria?

2021 ◽  
Vol 27 (18) ◽  
pp. 2054-2072
Author(s):  
Steve M D'Souza ◽  
Kevin Houston ◽  
Lauren Keenan ◽  
Byung Soo Yoo ◽  
Parth J Parekh ◽  
...  
Keyword(s):  
Paradigm Shift ◽  
Mucosal Disease ◽  
Microbial Dysbiosis

Posttransplant CMV infection and the role of immunosuppression (Sponsor: Novartis Pharma GmbH, Nürnberg)

2016 ◽  
Vol 04 (01) ◽  
pp. 4-10
Keyword(s):  
Lower Incidence ◽  
Paradigm Shift ◽  
Mtor Inhibitor ◽  
De Novo ◽  
Expert Panel ◽  
Risk Of Infection ◽  
Cmv Infection ◽  
Expert Meeting ◽  
Selection Of

AbstractImmunosuppression permits graft survival after transplantation and consequently a longer and better life. On the other hand, it increases the risk of infection, for instance with cytomegalovirus (CMV). However, the various available immunosuppressive therapies differ in this regard. One of the first clinical trials using de novo everolimus after kidney transplantation [1] already revealed a considerably lower incidence of CMV infection in the everolimus arms than in the mycophenolate mofetil (MMF) arm. This result was repeatedly confirmed in later studies [2–4]. Everolimus is now considered a substance with antiviral properties. This article is based on the expert meeting “Posttransplant CMV infection and the role of immunosuppression”. The expert panel called for a paradigm shift: In a CMV prevention strategy the targeted selection of the immunosuppressive therapy is also a key element. For patients with elevated risk of CMV, mTOR inhibitor-based immunosuppression is advantageous as it is associated with a significantly lower incidence of CMV events.

E-Projects Challenges in India – Role of Human Resource Management and Technology

2018 ◽  
Vol 6 (8) ◽  
pp. 263
Author(s):  
Ramnik Kaur
Keyword(s):  
Developing Countries ◽  
Public Administration ◽  
Paradigm Shift ◽  
Successful Implementation ◽  
The Public ◽  
Government Services ◽  
The Past ◽  
The Government ◽  
Traditional Approaches

E-governance is a paradigm shift over the traditional approaches in Public Administration which means rendering of government services and information to the public by using electronic means. In the past decades, service quality and responsiveness of the government towards the citizens were least important but with the approach of E-Government the government activities are now well dealt. This paper withdraws experiences from various studies from different countries and projects facing similar challenges which need to be consigned for the successful implementation of e-governance projects. Developing countries like India face poverty and illiteracy as a major obstacle in any form of development which makes it difficult for its government to provide e-services to its people conveniently and fast. It also suggests few suggestions to cope up with the challenges faced while implementing e-projects in India.

scholarly journals Microbiota Alterations in Precancerous Colon Lesions: A Systematic Review

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3061
Author(s):  
Francesca Aprile ◽  
Giovanni Bruno ◽  
Rossella Palma ◽  
Maria Teresa Mascellino ◽  
Cristina Panetta ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Endoscopic Resection ◽  
Causative Role ◽  
Health It ◽  
Microbial Dysbiosis ◽  
Pubmed Database ◽  
The Impact ◽  
The Relationship ◽  
Preventive Role

Gut microbiota plays an important role in human health. It may promote carcinogenesis and is related to several diseases of the gastrointestinal tract. This study of microbial dysbiosis in the etiology of colorectal adenoma aimed to investigate the possible causative role of microbiota in the adenoma–carcinoma sequence and its possible preventive role. A systematic, PRISMA-guided review was performed. The PubMed database was searched using “adenoma microbiota” and selecting original articles between January 2010 and May 2020 independently screened. A higher prevalence of Proteobacteria, Fusobacteria, and Bacteroidetes phyla was observed in the fecal luminal and mucosa-associated microbiota of patients with adenoma. However, other studies provided evidence of depletion of Clostridium, Faecalibacterium, Bacteroides and Romboutsia. Results on the relationship between adenoma endoscopic resection and microbiota were inconsistent. In conclusion, none of the analyzed studies developed a predictive model that could differentiate adenoma from non-adenoma patients, and therefore, to prevent cancer progression. The impact of adenoma’s endoscopic resection on microbiota was investigated, but the results were inconclusive. Further research in the field is required.

scholarly journals Can Blockchain Strengthen the Energy Internet?

Network ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 95-115
Author(s):  
Charithri Yapa ◽  
Chamitha de Alwis ◽  
Madhusanka Liyanage
Keyword(s):  
Distributed Generation ◽  
Paradigm Shift ◽  
Distribution Networks ◽  
Future Research ◽  
Disruptive Technology ◽  
Electricity Distribution ◽  
Energy Internet ◽  
Energy Delivery ◽  
Electricity Grids

Emergence of the Energy Internet (EI) demands restructuring of traditional electricity grids to integrate heterogeneous energy sources, distribution network management with grid intelligence and big data management. This paradigm shift is considered to be a breakthrough in the energy industry towards facilitating autonomous and decentralized grid operations while maximizing the utilization of Distributed Generation (DG). Blockchain has been identified as a disruptive technology enabler for the realization of EI to facilitate reliable, self-operated energy delivery. In this paper, we highlight six key directions towards utilizing blockchain capabilities to realize the envisaged EI. We elaborate the challenges in each direction and highlight the role of blockchain in addressing them. Furthermore, we summarize the future research directive in achieving fully autonomous and decentralized electricity distribution networks, which will be known as Energy Internet.

scholarly journals Herring and ICES: a historical sketch of a few ideas and their linkages

2009 ◽  
Vol 66 (8) ◽  
pp. 1652-1661 ◽  
Author(s):  
Mike Sinclair
Keyword(s):  
Paradigm Shift ◽  
Pelagic Fish ◽  
Marine Ecology ◽  
Effective Management ◽  
Paradigm Shifts ◽  
Population Thinking ◽  
Fish Stocks ◽  
Considerable Debate ◽  
Historical Sketch

Abstract Sinclair, M. 2009. Herring and ICES: a historical sketch of a few ideas and their linkages. – ICES Journal of Marine Science, 66: 1652–1661. This introduction to the Symposium on “Linking Herring” sketches the development of some ideas generated from herring research within an ICES context. The work of Committee A (1902–1908), under the leadership of Johan Hjort, led to a paradigm shift from “migration thinking” to “population thinking” as the interpretation of fluctuations in herring landings. From the 1920s to the 1950s, the focus on forecasting services for the herring fisheries, although ultimately unsuccessful, had the unintended consequence of generating ideas on recruitment overfishing and the match–mismatch hypothesis. The collapse of the East Anglian fishery led, in 1956, to considerable debate on its causes, but no consensus was reached. Three consecutive symposia dealing with herring (1961, 1968, and 1970) reveal a changing perspective on the role of fishing on recruitment dynamics, culminating in Cushing’s 1975 book (“Marine Ecology and Fisheries”, referred to here as the “Grand Synthesis”), which defined the concept of recruitment overfishing and established the future agenda for fisheries oceanography. The 1978 ICES “Symposium on the Assessment and Management of Pelagic Fish Stocks” is interpreted as the “Aberdeen Consensus” (i.e. without effective management, recruitment overfishing is to be expected). In conclusion, herring research within ICES has led to many ideas and two major paradigm shifts.

The Concept of the ‘Living Constitution’ in Russian Constitutional Theory and Practice

2021 ◽  
Vol 46 (3-4) ◽  
pp. 416-445
Author(s):  
Caroline von Gall
Keyword(s):  
Direct Effect ◽  
Paradigm Shift ◽  
Social Conditions ◽  
Theory And Practice ◽  
Constitutional Reform ◽  
Constitutional Theory ◽  
Constitutional Change ◽  
The Past ◽  
Margin Of Appreciation

Abstract In discussing the concept of the ‘living constitution’ in Russian constitutional theory and practice, this paper shows that the Russian concept of the living constitution differs from U.S. or European approaches to evolutive interpretation. The Russian concept has its roots in Soviet and pre-revolutionary Russian constitutional thinking. It reduces the normative power of the Constitution but allows an interpretation according to changing social conditions and gives the legislator a broad margin of appreciation. Whereas the 1993 Russian constitutional reform had been regarded as a paradigm shift with the intention to break with the past by declaring that the Constitution shall have supreme judicial force and direct effect, the paper also gives answers to the complexity of constitutional change and legal transplants and the role of constitutional theory and practice for the functioning of the current authoritarian regime in Russia.

scholarly journals The taxonomy, biogeography and conservation of the myrmecophilous Chrysoritis butterflies (Lepidoptera: Lycaenidae) in South Africa

Koedoe ◽  
2003 ◽  
Vol 46 (2) ◽  
Author(s):  
R.F. Terblanche ◽  
H. Van Hamburg
Keyword(s):  
South Africa ◽  
National Parks ◽  
Paradigm Shift ◽  
Butterfly Species ◽  
Conservation Action ◽  
Research Fields ◽  
Species Lists ◽  
Species Groups ◽  
Valuable Role

The relevance and integration of scientific knowledge to conservation management of the locally popular and highly endemic butterfly genus Chrysoritis are investigated within the research fields of taxonomy and biogeography. The butterfly genus Chrysoritis contains at least 41 species endemic to South Africa. The taxonomy of Chrysoritis has reached a state where revisions could easily result in a plethora of names between “lumping and splitting”. In practice, the state of the taxonomy of these butterflies on species level may alter their conservation priority. The two most species rich species groups in Chrysoritis have different centres of endemism, however, a butterfly atlas becomes a necessity to reveal more about their biogeography. There is an absence of butterfly species lists in many of our National Parks and Nature Reserves. Legislation should facilitate rather than limit the valuable role of the amateur lepidopterist to add distribution records. In turn, the amateur lepidopterists should adapt and make an effort to explore unknown localities, apart from monitoring butterflies at their well-known localities. The red listing of localised butterflies in South Africa, including a number of Chrysoritis species, is in need of an urgent review in the light of the most recent IUCN categories. A species such as Chrysoritis dicksoni should be protected by law - but at its known localities. The scenario that real conservation action is only needed if the last known locality of a butterfly is threatened, should be abolished. A paradigm shift to conserve the metapopulations of the highly endemic Chrysoritis genus and not merely a few of its species as items that appear on lists, seems necessary.

scholarly journals Efficient utilization of renewable feedstocks: the role of catalysis and process design

2017 ◽  
Vol 376 (2110) ◽  
pp. 20170064 ◽  
Author(s):  
Regina Palkovits ◽  
Irina Delidovich
Keyword(s):  
Elevated Temperature ◽  
Gas Phase ◽  
Process Design ◽  
Circular Economy ◽  
Paradigm Shift ◽  
Efficient Utilization ◽  
Polar Solvents ◽  
Platform Chemicals ◽  
Renewable Feedstocks

Renewable carbon feedstocks such as biomass and CO 2 present an important element of future circular economy. Especially biomass as highly functionalized feedstock provides manifold opportunities for the transformation into attractive platform chemicals. However, this change of the resources requires a paradigm shift in refinery design. Fossil feedstocks are processed in gas phase at elevated temperature. In contrast, biorefineries are based on processes in polar solvents at moderate conditions to selectively deoxygenate the polar, often thermally instable and high-boiling molecules. Here, challenges of catalytic deoxygenation, novel strategies for separation and opportunities provided at the interface to biotechnology are discussed in form of showcases. This article is part of a discussion meeting issue ‘Providing sustainable catalytic solutions for a rapidly changing world’.

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