The role of growth hormone and amino acids on brain protein synthesis in aged rats given proteins of different quantity and quality

Amino Acids ◽  
2006 ◽  
Vol 32 (2) ◽  
pp. 247-253 ◽  
Author(s):  
M. Ohsumi ◽  
X. Shi ◽  
T. Tuchiya ◽  
K. Tujioka ◽  
S. Lyou ◽  
...  
Keyword(s):  
Amino Acids ◽  
Growth Hormone ◽  
Protein Synthesis ◽  
Aged Rats ◽  
Brain Protein ◽  
Brain Protein Synthesis

scholarly journals The Growth Hormone Affects the Brain Protein Synthesis Rate in Hypophysectomized Aged Rats

2008 ◽  
Vol 54 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Miho OHSUMI ◽  
Kazuyo TUJIOKA ◽  
Kazutoshi HAYASE ◽  
Shinichi NAGATA ◽  
Hidehiko YOKOGOSHI
Keyword(s):  
Growth Hormone ◽  
Protein Synthesis ◽  
Synthesis Rate ◽  
Protein Synthesis Rate ◽  
Aged Rats ◽  
Brain Protein ◽  
Brain Protein Synthesis ◽  
The Brain

scholarly journals Effect of Dietary Protein Quality on the Brain Protein Synthesis Rate in Aged Rats.

1999 ◽  
Vol 45 (4) ◽  
pp. 481-489 ◽  
Author(s):  
Miho KOIE ◽  
Miyuki TANAKA ◽  
Kazutoshi HAYASE ◽  
Akira YOSHIDA ◽  
Hidehiko YOKOGOSHI
Keyword(s):  
Protein Synthesis ◽  
Dietary Protein ◽  
Protein Quality ◽  
Synthesis Rate ◽  
Protein Synthesis Rate ◽  
Aged Rats ◽  
Brain Protein ◽  
Brain Protein Synthesis ◽  
The Brain

scholarly journals The effects of chronic hyperphenylalaninaemia on mouse brain protein synthesis can be prevented by other amino acids

1982 ◽  
Vol 206 (2) ◽  
pp. 407-414 ◽  
Author(s):  
P Binek-Singer ◽  
T C Johnson
Keyword(s):  
Amino Acids ◽  
Protein Synthesis ◽  
Amino Acid ◽  
Polypeptide Chain ◽  
Amino Acid Mixture ◽  
Chain Elongation ◽  
Acid Mixture ◽  
Brain Protein ◽  
Brain Protein Synthesis ◽  
The Brain

A prolonged elevation in the concentrations of circulating phenylalanine was maintained in newborn mice by daily injections of phenylalanine and a phenylalanine hydroxylase inhibitor, alpha-methylphenylalanine. The result of this chronic hyperphenylalaninaemia was an accumulation of vacant or inactive monoribosomes that persisted for 18 h of each day. An elongation assay in vitro with brain postmitochondrial supernatants demonstrated that, in addition, there was an equally prolonged decrease in the rates of polypeptide-chain elongation by the remaining brain polyribosomes. Analyses of the free amino acid composition in the brains of hyperphenylalaninaemic mice showed a loss of several amino acids from the brain, particularly the large, neutral amino acids, which are co- or counter-transported across plasma membranes with phenylalanine. When a mixture of these amino acids (leucine, isoleucine, valine, threonine, tryptophan, tyrosine, methionine) was injected into hyperphenylalaninaemic mice, there was an immediate cessation of monoribosome accumulation in the brain and there was no inhibition of the rates of polypeptide-chain elongation. Although the concentrations of the large, neutral amino acids in the brain were partially preserved by treatment of hyperphenylalaninaemic mice with the amino acid mixture, the elevated concentrations of phenylalanine remained unaltered. The amino acid mixture had no detectable effect on brain protein synthesis in the absence of the hyperphenylalaninaemic condition.

scholarly journals Effect of Dietary γ-Aminobutyric Acid on the Brain Protein Synthesis Rate in Hypophysectomized Aged Rats

2011 ◽  
Vol 57 (4) ◽  
pp. 285-291 ◽  
Author(s):  
Kazuyo TUJIOKA ◽  
Miho OHSUMI ◽  
Kazuhiro SAKAMOTO ◽  
Panicha THANAPREEDAWAT ◽  
Masahiro AKAO ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Aminobutyric Acid ◽  
Synthesis Rate ◽  
Protein Synthesis Rate ◽  
Aged Rats ◽  
Brain Protein ◽  
Brain Protein Synthesis ◽  
The Brain
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