Differences in the relation between bone mineral content and lean body mass according to gender and reproductive status by age ranges

2018 ◽  
Vol 37 (4) ◽  
pp. 749-758
Author(s):  
Edgar Denova-Gutiérrez ◽  
Patricia Clark ◽  
Ricardo Francisco Capozza ◽  
Laura Marcela Nocciolino ◽  
Jose Luis Ferretti ◽  
...  
2002 ◽  
Vol 87 (7) ◽  
pp. 3368-3372 ◽  
Author(s):  
Andrea F. Attanasio ◽  
Simon Howell ◽  
Peter C. Bates ◽  
Paul Frewer ◽  
John Chipman ◽  
...  

If GH therapy of children with GH deficiency (GHD) has been adequate, body composition should be comparable to that of patients who have undergone normal childhood development and become hypopituitary thereafter. To assess this, body composition was determined in 92 patients with childhood onset (CO) GHD, aged 18–30 yr, who had been treated to final height with GH for 8.98 ± 4.30 yr and had stopped treatment 1.57 ± 1.20 yr previously, but who remained GHD (assessed by a GH stimulation test and IGF-I values). These were compared with 35 age-matched GH-naïve hypopituitary patients with adult onset (AO) GHD. Lean body mass, fat mass, and total bone mineral content were assessed by dual energy x-ray absorptiometry and corrected for actual height. CO patients were shorter (CO height, −1.18 ± 1.16 sd score; AO height, −0.38 ± 1.12 sd score; P < 0.001) and had lower body mass index (CO, 23.19 ± 5.76 kg/m2; AO, 28.9 ± 6.27 kg/m2; P < 0.001) than the AO group. Although there were gender differences, within genders CO patients had lower lean body mass, fat mass, and bone mineral content (P < 0.001 in all cases) compared with AO patients. Standard deviation scores for IGF-I (CO female, −9.2 ± 3.1; AO female, −5.2 ± 2.6; CO male, −6.4 ± 2.7; AO male, −3.5 ± 2.3; P < 0.001 within each gender) and IGFBP-3 (CO female, −3.5 ± 2.5; AO female, −1.7 ± 1.5; CO male, −2.8 ± 2.0; AO male, −1.1 ± 1.6; P < 0.001 within each gender) were significantly lower in the CO group. These results suggest that patients with CO GHD who were treated to final height suffer a significant maturational deficit despite GH replacement during childhood.


1981 ◽  
Vol 33 (1) ◽  
pp. 5-8 ◽  
Author(s):  
Merete Sanvig Christensen ◽  
Claus Christiansen ◽  
Jørgen Næstoft ◽  
Peter McNair ◽  
Ib Transbøl

Bone ◽  
2004 ◽  
Vol 35 (4) ◽  
pp. 965-972 ◽  
Author(s):  
N.J. Crabtree ◽  
M.S. Kibirige ◽  
J.N. Fordham ◽  
L.M. Banks ◽  
F. Muntoni ◽  
...  

1998 ◽  
Vol 30 (Supplement) ◽  
pp. 179
Author(s):  
K. S Davison ◽  
R. L. Mirwald ◽  
R. A. Faulkner ◽  
D. A. Bailey

Bone ◽  
1998 ◽  
Vol 22 (6) ◽  
pp. 683-690 ◽  
Author(s):  
J.L Ferretti ◽  
R.F Capozza ◽  
G.R Cointry ◽  
S.L García ◽  
H Plotkin ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2562
Author(s):  
Antonio Hernandez-Martin ◽  
Jorge Garcia-Unanue ◽  
Alejandro Martinez-Rodriguez ◽  
Samuel Manzano-Carrasco ◽  
Jose Luis Felipe ◽  
...  

Dietary patterns, exercise, sport, and physical activity have been shown to improve body composition in children. This systematic review with meta-analysis analyzed the effects of practicing football on body composition (fat mass, lean body mass, and bone mineral content) in children. An initial search in PubMed, Web of Science, and SPORTDiscus was carried out in April 2021 to identify relevant articles. Inclusion criteria required children up to 12 years of age with a minimum football intervention duration of 10 weeks. Methodological quality of the articles was evaluated using the PEDro scale. Between the 1803 articles originally founded, only 14 articles were included in the meta-analysis. A total of 1643 subjects between the 14 studies were identified. The review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and used Review Manager and Full Meta-Analysis software. The results between the control and experimental groups showed significantly better lean body mass and fat mass values in the experimental group (p < 0.05). Football practice was positively associated with increases in lean body mass (mean difference of 1.55; 95% CI, 0.96, 2.15), decreases in fat mass (mean difference of −0.81; 95% CI, −1.49, −0.13), and increases in whole body bone mineral content (mean difference of 117.68; 95% CI, 83.69, 151.67). In conclusion, the results of this systematic review with meta-analysis suggest that football positively affects body composition in children. However, further research is needed to confirm the results for bone mineral content.


1997 ◽  
Vol 61 (2) ◽  
pp. 134-138 ◽  
Author(s):  
M. Revilla ◽  
L. F. Villa ◽  
A. Sánchez-Atrio ◽  
E. R. Hernández ◽  
H. Rico

Lupus ◽  
2016 ◽  
Vol 26 (8) ◽  
pp. 808-814 ◽  
Author(s):  
C Elera-Fitzcarrald ◽  
M F Ugarte-Gil ◽  
R V Gamboa-Cárdenas ◽  
F Zevallos ◽  
M Medina ◽  
...  

Objectives The objective of this study was to determine whether prolactin levels are associated with a pro-inflammatory body mass distribution in women with systemic lupus erythematosus (SLE). Methods This cross-sectional study was conducted in consecutive female SLE patients seen in our rheumatology department from January 2012 to July 2015. Prolactin was measured in ng/ml. Body mass distribution was measured by dual energy x-ray absorptiometry and it was divided into subtotal (whole body excluding the head), subtotal bone mineral content, lean mass index (appendicular lean mass/height2), subtotal trunk and leg fat percentages and trunk-to-leg fat ratio. The association between prolactin levels and body mass distribution components was evaluated by univariable and multivariable linear regression models adjusting for possible confounders. Results One hundred and eighty-five patients were evaluated; their mean (SD) age at diagnosis was 34.8 (13.8) years; nearly all patients were Mestizo. Patients included in this study were comparable to the rest of the cohort in terms of age, disease duration, SLEDAI, SDI and body mass index. Disease duration was 7.3 (6.6) years. The SLEDAI was 5.2 (4.3) and the SDI 0.9 (1.3). Prolactin levels were 18.9 (16.7) ng/ml. In univariable analyses, prolactin was negatively associated with bone mineral density, bone mineral content, leg fat percentage and lean mass index, and positively associated with trunk-to-leg fat ratio. In the multivariable analyses, prolactin was negatively associated with bone mineral content and positively associated with trunk-to-leg fat ratio. Conclusions Higher prolactin levels are associated with a pro-inflammatory body mass distribution in SLE patients.


2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Julia Clarke ◽  
Hugo Peyre ◽  
Marianne Alison ◽  
Anne Bargiacchi ◽  
Coline Stordeur ◽  
...  

Abstract Background Early-onset anorexia nervosa (EO-AN) represents a significant clinical burden to paediatric and mental health services. The impact of EO-AN on bone mineral abnormalities has not been thoroughly investigated due to inadequate control for pubertal status. In this study, we investigated bone mineral abnormalities in girls with EO-AN regardless of pubertal development stage. Method We conducted a cross-sectional study of 67 girls with EO-AN (median age = 12.4 [10.9–13.7 years]) after a median duration of disease of 1.3 [0.6–2.0] years, and 67 healthy age-, sex-, pubertal status- matched control subjects. We compared relevant bone mineral parameters between groups: the total body bone mineral density [TB-BMD], the lumbar spine BMD [LS-BMD], the total body bone mineral content [TB-BMC] and the ratio of the TB-BMC to lean body mass [TB-BMC/LBM]. Results TB-BMD, TB-BMC, LS-BMD and TB-BMC/LBM were all significantly lower in patients with AN compared to controls. In the EO-AN group, older age, later pubertal stages and higher lean body mass were associated with higher TB-BMC, TB-BMD, and LS-BMD values. Discussion Girls with EO-AN displayed deficits in bone mineral content and density after adjustment for pubertal maturation. Age, higher pubertal stage and lean body mass were identified as determinants of bone maturation in the clinical population of patients with EO-AN. Bone health should be promoted in patients, specifically in those with an onset of disorder before 14 years old and with a delayed puberty.


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