Towards improved boron neutron capture therapy agents: evaluation of in vitro cellular uptake of a glutamine-functionalized carborane

The quality manajement system program of in vitro / in vivo test facility of Boron Neutron Capture Therapy (BNCT) methode as quality assurance requirement for utilization of radial pearcing beamport of Kartini research have been done. Identification and management of technical specification and parameters meassurement of to the radial piercing beamport have been determined for preparing in vitro / in vivo test facility. The parameters are epithermal neutron flux is 9,8243E+05 n cm-2 s-1and thermal neutron flux is 3,0691E+06 n cm-2 s-1, radiation shielding of parafin, dimension and size of piercing radial and instrumentatin and control system for automatic transfer of in vitro / in vivo samplels have been documented. Management system of the documents for fullfil basic guidance to perform working job of in vitro / in vivo at the piercing radial beamport of Kartini Research Reactor in order purpose utilization of the reactor for safety worker of the radiation area, society and invironment beeing safely

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Cyclic-RGDyC functionalized liposomes for dual-targeting of tumor vasculature and cancer cells in glioblastoma: An in vitro boron neutron capture therapy study

Oncotarget ◽

10.18632/oncotarget.16625 ◽

2017 ◽

Vol 8 (22) ◽

pp. 36614-36627 ◽

Cited By ~ 20

Author(s):

Weirong Kang ◽

Darren Svirskis ◽

Vijayalekshmi Sarojini ◽

Ailsa L. McGregor ◽

Joseph Bevitt ◽

...

Keyword(s):

Cancer Cells ◽

Boron Neutron Capture Therapy ◽

Neutron Capture ◽

Tumor Vasculature ◽

Neutron Capture Therapy ◽

Boron Neutron Capture ◽

Dual Targeting

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Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

10.1101/471128 ◽

2018 ◽

Cited By ~ 1

Author(s):

Guillaume Vares ◽

Vincent Jallet ◽

Yoshitaka Matsumoto ◽

Cedric Rentier ◽

Kentaro Takayama ◽

...

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Boron Neutron Capture Therapy ◽

Neutron Capture ◽

Mesoporous Silica Nanoparticles ◽

Alpha Particles ◽

Neutron Capture Therapy ◽

Boron Neutron Capture

AbstractTreatment resistance, relapse and metastasis remain critical issues in some challenging cancers, such as chondrosarcomas. Boron-neutron Capture Therapy (BNCT) is a targeted radiation therapy modality that relies on the ability of boron atoms to capture low energy neutrons, yielding high linear energy transfer alpha particles. We have developed an innovative boron-delivery system for BNCT, composed of multifunctional fluorescent mesoporous silica nanoparticles (B-MSNs), grafted with an activatable cell penetrating peptide (ACPP) for improved penetration in tumors and with Gadolinium for magnetic resonance imaging (MRI)in vivo. Chondrosarcoma cells were exposedin vitroto an epithermal neutron beam after B-MSNs administration. BNCT beam exposure successfully induced DNA damage and cell death, including in radio-resistant ALDH+ cancer stem cells (CSCs), suggesting that BNCT using this system might be a suitable treatment modality for chondrosarcoma or other hard-to-treat cancers.

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Boron neutron capture therapy in cancer: past, present and future

Arquivos Brasileiros de Endocrinologia & Metabologia ◽

10.1590/s0004-27302007000500024 ◽

2007 ◽

Vol 51 (5) ◽

pp. 852-856 ◽

Cited By ~ 25

Author(s):

Mario A. Pisarev ◽

Maria Alejandra Dagrosa ◽

Guilermo J. Juvenal

Keyword(s):

Boron Neutron Capture Therapy ◽

Neutron Capture ◽

Alpha Particles ◽

Neutron Capture Therapy ◽

Selective Uptake ◽

Complete Control ◽

Boron Neutron Capture ◽

A Cell ◽

Undifferentiated Thyroid Cancer

Undifferentiated thyroid cancer (UTC) is a very aggressive tumor with no effective treatment, since it lacks iodine uptake and does not respond to radio or chemotherapy. The prognosis of these patients is bad, due to the rapid growth of the tumor and the early development of metastasis. Boron neutron capture therapy (BNCT) is based on the selective uptake of certain boron non-radioactive compounds by a tumor, and the subsequent irradiation of the area with an appropriate neutron beam. 10B is then activated to 11B, which will immediately decay releasing alpha particles and 7Li, of high linear energy transfer (LET) and limited reach. Clinical trials are being performed in patients with glioblastoma multiforme and melanoma. We have explored its possible application to UTC. Our results demonstrated that a cell line of human UTC has a selective uptake of borophenylalanine (BPA) both in vitro and after transplantation to nude mice. Treatment of mice by BNCT led to a complete control of growth and cure of 100% of the animals. Moreover dogs with spontaneous UTC also have a selective uptake of BPA. At the present we are studying the biodistribution of BPA in patients with UTC before its application in humans.

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