Cellular uptake evaluation of pentagamaboronon-0 (PGB-0) for boron neutron capture therapy (BNCT) against breast cancer cells

2019 ◽  
Vol 37 (6) ◽  
pp. 1292-1299
Author(s):  
Adam Hermawan ◽  
Ratna Asmah Susidarti ◽  
Ratna Dwi Ramadani ◽  
Lailatul Qodria ◽  
Rohmad Yudi Utomo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Breast Cancer Cells ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

scholarly journals Chitosan Coating Effect on Cellular Uptake of PLGA Nanoparticles for Boron Neutron Capture Therapy

2019 ◽  
Vol 68 (4) ◽  
pp. 361-368 ◽  
Author(s):  
Issei Takeuchi ◽  
Mayu Ariyama ◽  
Kimiko Makino
Keyword(s):  
Cellular Uptake ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Plga Nanoparticles ◽  
Neutron Capture Therapy ◽  
Chitosan Coating ◽  
Boron Neutron Capture

Bahan Sasaran Sebagai Sumber Neutron yang Optimal untuk Boron Neutron Capture Therapy (BNCT)

2017 ◽  
Vol 1 ◽  
pp. 104
Author(s):  
Yan Surono ◽  
C Cari ◽  
Yohannes Sarjono
Keyword(s):  
Cancer Cells ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Radioactive Elements ◽  
Therapeutic Technique ◽  
The Core ◽  
Boron Neutron Capture ◽  
Deadly Disease ◽  
Α Particles

<p><strong>Abstract</strong> Cancer is a deadly disease that exist on planet earth. Efforts were made to be able to kill cancer cells either by manual operation or by radiotherapy. One way to use energy radiation radioactive elements as killers of cancer cells is Boron Neutron Capture Therapy (BNCT). BNCT is a therapeutic technique that utilizes the interaction of neutron capture by the core 10B will produce α-particles and nuclei 7Li results by reaction 10B (n, α) 7Li. It therefore requires a material that will produce neutrons used in BNCT. Materials  target that will be searched in order to obtain optimal materials according to the requirements provided by the International Atomic Agency (IAEA).<em></em></p><p><em> </em></p><p><strong>Keywords </strong>: Kanker, Material, Neutron, BNCT</p><p align="center"><strong><em> </em></strong></p><p><strong>Abstrak</strong> Kanker adalah salah satu penyakit yang mematikan yang ada di planet bumi. Upaya upaya dilakukan untuk dapat membunuh sel kanker baik itu  secara operasi manual maupun dengan cara radioterapi. Salah satu cara yang memanfaatkan energi radiasi unsur unsur radioaktif sebagai pembunuh sel kanker adalah Boron Neutron Capture Therapy (BNCT). BNCT merupakan teknik terapi yang memanfaatkan interaksi tangkapan neutron oleh inti 10B yang akan menghasilkan partikel-α dan inti hasil 7Li melalui reaksi 10B(n,α) 7Li. Oleh sebab itu diperlukan material yang akan menghasilkan neutron digunakan dalam BNCT. Bahan - bahan sasaran yang akan ditelusur dalam upaya mendapatkan bahan yang optimal sesuai persyaratan yang diberikan oleh International Atomic Agency (IAEA).</p><p><em> </em></p><p><strong>Kata Kunci </strong>: Kanker, Material, Neutron, BNCT</p>

Towards improved boron neutron capture therapy agents: evaluation of in vitro cellular uptake of a glutamine-functionalized carborane

2009 ◽  
Vol 14 (6) ◽  
pp. 883-890 ◽  
Author(s):  
Antonella Crivello ◽  
Carlo Nervi ◽  
Roberto Gobetto ◽  
Simonetta Geninatti Crich ◽  
Iboya Szabo ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

scholarly journals Cyclic-RGDyC functionalized liposomes for dual-targeting of tumor vasculature and cancer cells in glioblastoma: An in vitro boron neutron capture therapy study

Oncotarget ◽  
2017 ◽  
Vol 8 (22) ◽  
pp. 36614-36627 ◽  
Author(s):  
Weirong Kang ◽  
Darren Svirskis ◽  
Vijayalekshmi Sarojini ◽  
Ailsa L. McGregor ◽  
Joseph Bevitt ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Tumor Vasculature ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Dual Targeting

Uptake and metabolism of boronophenylalanine in human uveal melanoma cells in culture Relevance to boron neutron capture therapy of cancer cells

Amino Acids ◽  
1995 ◽  
Vol 8 (2) ◽  
pp. 217-229 ◽  
Author(s):  
R. Belkhou ◽  
J. -Ch. Abb� ◽  
P. Pham ◽  
N. Jasner ◽  
J. Sahel ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Uveal Melanoma ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Melanoma Cells ◽  
Neutron Capture Therapy ◽  
Cells In Culture ◽  
Boron Neutron Capture ◽  
Uptake And Metabolism

scholarly journals Monte Carlo assessment of boron neutron capture therapy for the treatment of breast cancer

2005 ◽  
Vol 20 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Daniel Mundy ◽  
Tatjana Jevremovic
Keyword(s):  
Breast Cancer ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Boron Concentration ◽  
Treatment Options ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Thermal Neutron Irradiation ◽  
Starting Point ◽  
Her 2

For a large number of women who are diagnosed with breast cancer every year the avail able treatment options are effective, though physically and mentally taxing. This work is a starting point of a study of the efficacy of boron neutron capture therapy as an alternative treatment for HER-2+ breast tumors. Using HER-2-specific monoclonal anti bodies coupled with a boron-rich oligomeric phosphate diester, it may be possible to deliver sufficient amounts of 10B to a tumor of the breast to al low for selective cell destruction via irradiation by thermal neutrons. A comprehensive computational model (MCNP) for thermal neutron irradiation of the breast is described, as well as the results of calculations made using this model, in order to determine the optimum boron concentration within the tumor for an effective boron neutron capture therapy treatment, as compared with traditional X-ray radiotherapy. The results indicate that a boron concentration of 50-60 mg per gram of tumor tissue is optimal when considering treatment times, dose distributions and skin sparing. How ever these results are based upon best-guess assumptions that must be experimentally verified.

scholarly journals Analysis of Radiation Interactions and Biological Effects for Boron Neutron Capture Therapy

2018 ◽  
Vol 35 (3) ◽  
pp. 203-207
Author(s):  
Ren-Tai Chiang
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Blood Supply ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Biological Effects ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Cancer Tumor ◽  
Ionizing Radiations

 The direct and indirect ionizing radiation sources for boron neutron capture therapy (BNCT)are identi?ed. The mechanisms of physical, chemical and biological radiation interactions for BNCT are systematically described and analyzed. The relationship between the effect of biological radiation and radiation dose are illustrated and analyzed for BNCT. If the DNAs in chromosomes are damaged by ion- izing radiations, the instructions that control the cell function and reproduction are also damaged. This radiation damage may be reparable, irreparable, or incorrectly repaired. The irreparable damage can result in cell death at next mitosis while incorrectly repaired damage can result in mutation. Cell death leads to variable degrees of tissue dysfunction, which can affect the whole organism’s functions. Can- cer cells cannot live without oxygen and nutrients via the blood supply. A cancer tumor can be shrunk by damaging angiogenic factors and/or capillaries via ionizing radiations to decrease blood supply into the cancer tumor. The collisions between ionizing radiations and the target nuclei and the absorption of the ultraviolet, visible light, infrared and microwaves from bremsstrahlung in the tumor can heat up and damage cancer cells and function as thermotherapy. The cancer cells are more chemically and biologically sensitive at the BNCT-induced higher temperatures since free-radical-induced chemical re- actions are more random and vigorous at higher temperatures after irradiation, and consequently the cancer cells are harder to divide or even survive due to more cell DNA damage. BNCT is demonstrated via a recent clinical trial that it is quite effective in treating recurrent nasopharyngeal cancer.

Functionalization and Cellular Uptake of Boron Carbide Nanoparticles. The First Step toward T Cell-Guided Boron Neutron Capture Therapy

2006 ◽  
Vol 17 (2) ◽  
pp. 284-290 ◽  
Author(s):  
M. W. Mortensen ◽  
O. Björkdahl ◽  
P. G. Sørensen ◽  
T. Hansen ◽  
M. R. Jensen ◽  
...  
Keyword(s):  
T Cell ◽  
Boron Carbide ◽  
Cellular Uptake ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture
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