Bis(triazinyl)pyridine complexes of Pt(II) and Pd(II): studies of the nucleophilic substitution reactions, DNA/HSA interactions, molecular docking and biological activity

2021 ◽  
Author(s):  
Snežana Jovanović-Stević ◽  
Snežana Radisavljević ◽  
Andreas Scheurer ◽  
Dušan Ćoćić ◽  
Biljana Šmit ◽  
...  
Keyword(s):  
Biological Activity ◽  
Molecular Docking ◽  
Nucleophilic Substitution ◽  
Substitution Reactions ◽  
Nucleophilic Substitution Reactions ◽  
Pyridine Complexes

Homo- and hetero-dinuclear Pt(ii)/Pd(ii) complexes: studies of hydrolysis, nucleophilic substitution reactions, DNA/BSA interactions, DFT calculations, molecular docking and cytotoxic activity

2020 ◽  
Vol 49 (41) ◽  
pp. 14411-14431
Author(s):  
Dušan Ćoćić ◽  
Snežana Jovanović-Stević ◽  
Ratomir Jelić ◽  
Sanja Matić ◽  
Suzana Popović ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Dft Calculations ◽  
Cytotoxic Activity ◽  
Nucleophilic Substitution ◽  
Dinuclear Complexes ◽  
Substitution Reactions ◽  
Nucleophilic Substitution Reactions

Dinuclear complexes [Pd2(tpbd)Cl2]Cl2, [Pt2(tpbd)Cl2]Cl2 and [PdPt(tpbd)Cl2]Cl2 (tpbd = N,N,N′,N′-tetrakis(2-pyridylmethyl)benzene-1,4-diamine) have been synthesized and the kinetic, interactions with DNA/BSA and cytotoxic activity were studied.

Studies of the stability, nucleophilic substitution reactions, DNA/BSA interactions, cytotoxic activity, DFT and molecular docking of some tetra- and penta-coordinated gold(iii) complexes

2020 ◽  
Vol 44 (26) ◽  
pp. 11172-11187
Author(s):  
Snežana Radisavljević ◽  
Ana Đeković Kesić ◽  
Dušan Ćoćić ◽  
Ralph Puchta ◽  
Laura Senft ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Cytotoxic Activity ◽  
Nucleophilic Substitution ◽  
Substitution Reactions ◽  
Nucleophilic Substitution Reactions ◽  
Tu 5 ◽  
The Stability

The stability in water and at pH = 7.2, substitution reactions with Tu, 5’-GMP, GSH and l-Met, DNA/BSA interactions, cytotoxicity, DFT and molecular docking of gold(iii) complexes with phenanthroline derivatives as inert ligands were studied.

scholarly journals SYNTHETIC AND BIOLOGICAL UTILITY OF 2,3-DICHLORO-1,4-NAPHTHOQUINONE: A REVIEW

2020 ◽  
Vol 7 (10) ◽  
pp. 293-347
Author(s):  
Hardesh K. Maurya
Keyword(s):  
Biological Activity ◽  
Nucleophilic Substitution ◽  
Biologically Active ◽  
Substitution Reactions ◽  
Nucleophilic Substitution Reactions ◽  
Anti Hiv

2,3-Dichloro-1,4-naphthoquinones (dichlone) have attracted considerable attention for the construction of biologically active tricyclic and tetracyclic 1,4-quinones and other derivatives. A diversified reaction of 2,3-dichloro-1,4-naphthoquinones such as cycloaddition, condensation, photo induced and nucleophilic substitution reactions with suitable nucleophiles viz. carbon, nitrogen, oxygen, sulfur, selenium etc have been explored. Various synthesized compounds have also explored for their biological activity such as antifungal, antibacterial, anticancer, antiplatlet, anti-inflamentry, anti-allergic and anti HIV. This review describes the chemistry and biological activity of compounds synthesized from 2,3-dichloro-1,4-naphthoquinones during the last three decades.

The unexpected reactivity of 9-iodo-nido-carborane: from nucleophilic substitution reactions to the synthesis of tricobalt tris(dicarbollide) Na[4,4′,4′′-(MeOCH2CH2O)3-3,3′,3′′-Co3(μ3-O)(μ3-S)(1,2-C2B9H10)3]

2021 ◽  
Vol 50 (7) ◽  
pp. 2671-2688
Author(s):  
Marina Yu. Stogniy ◽  
Sergey A. Anufriev ◽  
Akim V. Shmal'ko ◽  
Sergey M. Antropov ◽  
Aleksei A. Anisimov ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reactions ◽  
Nucleophilic Substitution Reactions

An unusual reactivity of 9-iodo-nido-carborane [9-I-7,8-C2B9H11]− towards nucleophiles under strong basic conditions was revealed.

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