Prognostic significance of neural stem cell markers, Nestin and Musashi-1, in oral squamous cell carcinoma: expression pattern of Nestin in the precancerous stages of oral squamous epithelium

2014 ◽  
Vol 19 (6) ◽  
pp. 1251-1260 ◽  
Author(s):  
Gokulan Ravindran ◽  
Halagowder Devaraj
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Expression Pattern ◽  
Neural Stem Cell ◽  
Squamous Cell ◽  
Squamous Epithelium ◽  
Prognostic Significance ◽  
Stem Cell Markers

scholarly journals Interferon-α Promotes the Expression of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma

2017 ◽  
Vol 8 (12) ◽  
pp. 2384-2393 ◽  
Author(s):  
Hailong Ma ◽  
Shufang Jin ◽  
Wenyi Yang ◽  
Zhuowei Tian ◽  
Shuli Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Interferon Α ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cancer Stem Cell Markers

scholarly journals Cancer stem cell markers in patterning differentiation and in prognosis of oral squamous cell carcinoma

Tumor Biology ◽  
2017 ◽  
Vol 39 (6) ◽  
pp. 101042831770365 ◽  
Author(s):  
Simple Mohanta ◽  
Gangotri Siddappa ◽  
Sindhu Govindan Valiyaveedan ◽  
Ravindra Dodda Thimmasandra Ramanjanappa ◽  
Debashish Das ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cancer Stem Cell Markers

scholarly journals Prognostic Relevance of CD4+, CD8+ and FOXP3+ TILs in Oral Squamous Cell Carcinoma and Correlations with PD-L1 and Cancer Stem Cell Markers

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 653
Author(s):  
Paloma Lequerica-Fernández ◽  
Julián Suárez-Canto ◽  
Tania Rodriguez-Santamarta ◽  
Juan Pablo Rodrigo ◽  
Faustino Julián Suárez-Sánchez ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Independent Prognostic Factor ◽  
Stem Cell Markers ◽  
Cancer Stem Cell Markers

This study investigates the relevance of tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis of stromal/tumoral CD4+, CD8+ and FOXP3+ TILs is performed in 125 OSCC patients. Potential relationships with the expression of tumoral PD-L1 and cancer stem cell (CSC) markers (NANOG, SOX2, OCT4, Nestin and Podoplanin (PDPN)) are assessed. CD4+ and CD8+ TILs are significantly associated with smoking and alcohol habits. CD4+ and CD8+ TILs show an inverse relationship with NANOG and SOX2 expression, and FOXP3+ TILs is significantly correlated with Nestin and PDPN expression. High infiltration of CD4+ and CD8+ TILs and a high tumoral CD8+/FOXP3+ ratio are significantly associated with tumors harboring positive PD-L1 expression. Infiltration of stromal/tumoral FOXP3+ TILs and a low stromal CD8+/FOXP3+ ratio are significantly associated with better disease-specific survival. Multivariate analysis reveals that the stromal CD8+/FOXP3+ TILs ratio is a significant independent prognostic factor. Regarding OSCC patient survival, the CD8+/FOXP3+ TILs ratio is an independent prognostic factor. TILs may act as biomarkers and potential therapeutic targets for OSCC.

scholarly journals Expression Pattern of the Cancer Stem Cell Marker “Nestin” in Leukoplakia and Oral Squamous Cell Carcinoma

2019 ◽  
Vol 10 (4) ◽  
pp. e0024
Author(s):  
Kushbu Narender Singh ◽  
Madhavan Nirmal Ramadas ◽  
Veeravarmal Veeran ◽  
Murali Radhakrishnan Naidu ◽  
Thamarai Selvi Dhanaraj ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Expression Pattern ◽  
Squamous Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals Stem cell markers expression evaluation in Oral Squamous Cell Carcinoma

2021 ◽  
Vol 10 (13) ◽  
pp. e314101320840
Author(s):  
Julio Cesar Ramos Cadilho ◽  
Silvia Maria de Carvalho Lyra ◽  
Ana Beatriz Machado Lima ◽  
Carina Maciel da Silva Boghossian ◽  
Cláudia Maria Pereira
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Embryonic Stem ◽  
Tobacco Consumption ◽  
Stem Cell Markers ◽  
Cell Markers

Oral carcinogenesis is a highly complex process. Molecular studies demonstrate that some oral cancers progress from pre-neoplastic lesions. Cancer stem cells (CSCs), a small cellular group within the tumor, have currently received much attention by its self-renewal and tumor differentiation ability. It is considered that CSCs may be responsible for the relapse and metastasis of cancer. CSCs have been reported to express common embryonic stem cells markers such as Nestin and Nanog. The aim of the present study was to identify the presence of Nestin and Nanog markers in patients with oral squamous cell carcinoma (OSCC). Nine samples were collected from patients diagnosed with OSCC and two healthy oral mucosa were used as control. The markers expression in nine OSCC was determined by end-point PCR. The OSCC population analyzed was mostly composed of black and white males, with a mean age of 70.6 years, that reported alcohol and tobacco consumption. Nestin and Nanog stem cell markers were expressed in all OSCCs and normal samples analyzed. As these two markers have already been related to the mechanism of metastasis and relapses in cancer, its expression determination could help to understand the aggressive and invasive nature of OSCC.

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