Survivin expression in head and neck squamous cell carcinomas is frequent and correlates with clinical parameters and treatment outcomes

2018 ◽  
Vol 23 (1) ◽  
pp. 361-367 ◽  
Author(s):  
Adrian Münscher ◽  
Sebastian Prochnow ◽  
Amit Gulati ◽  
Guido Sauter ◽  
Balazs Lörincz ◽  
...  
2021 ◽  
Vol 6 (2) ◽  
pp. 99-104
Author(s):  
P Sakthidasan Chinnathambi ◽  
Deepak Kumar B

Squamous cell carcinomas constitute 95% of cancers of the head and neck region. The progression of disease in these patients depends on various molecular regulators. The present study is undertaken to identify the immunoexpression of Cyclin D1 in Head and Neck Squamous Cell Carcinomas (HNSCC) and to study their association with clinicopathological variables in routine diagnostics.1. To study the expression of Cyclin D1 in Head and Neck Squamous Cell Carcinomas by immunohistochemistry. 2. To correlate the expression of Cyclin D1 with histopathological grading and various demographic parameters.150 cases of HNSCCs were studied for a period of 18 months in ESIC MC & PGIMSR, Bangalore. The cases were subjected to immunohistochemical analysis of Cyclin D1 antigen. Immunoexpression of Cyclin D1 was correlated with histopathological differentiation and clinical parameters.Out of 150 cases; well, moderate and poorly differentiated grades constituted67, 63 and 20 cases respectively. Immunoexpression of Cyclin D1 wasfound in 100 % of the cases and they were significantly associated with worseninggrade of the tumour and positive lymph node disease while it was not found to be associated with other clinical parameters.Immunohistochemical analysis of cyclin D1 can be routinely done inHNSCC as it proves to be an effective, early prognostic indicator in predicting theadvanced stage of the disease and guiding appropriate management.


2014 ◽  
Vol 3 (2) ◽  
pp. 10-11
Author(s):  
Pallavi Sinha ◽  
Bimal Kumar Sinha ◽  
Dharma Kanta Baskota ◽  
Yogesh Neupane ◽  
Kunjan Acharya

DOI: http://dx.doi.org/10.3126/njenthns.v3i2.10154 Nepalese Journal of Head and Neck Surgery Vol.3(2) 2012: 10-11


1998 ◽  
Vol 23 (3) ◽  
pp. 268-269
Author(s):  
Liloglou ◽  
Scholes ◽  
Spandidos ◽  
Jones ◽  
Vaughan ◽  
...  

2005 ◽  
Vol 14 (2) ◽  
pp. 320-321
Author(s):  
Mehmet Gunduz ◽  
Esra Gunduz ◽  
Byung-Moo Min ◽  
Gene Lee ◽  
Ji-Jun Lim ◽  
...  

Oral Oncology ◽  
2011 ◽  
Vol 47 ◽  
pp. S46
Author(s):  
F.K.J. Leusink ◽  
P.J. Slootweg ◽  
M.W.M. van den Brekel ◽  
R.J. Baatenburg de Jong ◽  
F.C.P. Holstege ◽  
...  

2001 ◽  
Vol 19 (2) ◽  
pp. 127-136 ◽  
Author(s):  
John C. Grecula ◽  
David E. Schuller ◽  
Roy Smith ◽  
Chris A. Rhoades ◽  
Subir Nag ◽  
...  

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