Clear Cell Adenocarcinoma of the Cervix in a Child without in Utero Exposure to Diethylstilbestrol: A Case Report and Review of the Literature

2005 ◽  
Vol 8 (6) ◽  
pp. 690-695 ◽  
Author(s):  
William A. Ahrens ◽  
L. Patricia Barrón-Rodriguez ◽  
Millisa McKee ◽  
Scott Rivkees ◽  
Miguel Reyes-Múgica
Keyword(s):  
Differential Diagnosis ◽  
Clear Cell ◽  
Clinical History ◽  
In Utero ◽  
Embryonal Rhabdomyosarcoma ◽  
In Utero Exposure ◽  
Clear Cell Adenocarcinoma ◽  
Review Of The Literature ◽  
Cervical Tumor ◽  
History Of

We describe the case of a primary cervical tumor in a 6-year-old child that was originally suspected to be an embryonal rhabdomyosarcoma botryoides. Histologic analysis revealed a clear cell adenocarcinoma. Despite a direct search and questioning for maternal exposure to diethylstilbestrol, this was not documented. Clear cell adenocarcinoma is an extremely rare neoplasm that should be kept in the differential diagnosis of cervicovaginal lesions in children, even in the absence of a clinical history of in utero diethylstilbestrol exposure. We discuss the hypothesized pathogenesis and review the literature on this unusual tumor.

scholarly journals Metastasis of Malignant Melanoma to Urinary Bladder: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Rashna Meunier ◽  
Gyan Pareek ◽  
Ali Amin
Keyword(s):  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Urinary Bladder ◽  
Clinical History ◽  
Metastatic Malignant Melanoma ◽  
Review Of The Literature ◽  
Bladder Mucosa ◽  
Immunohistochemical Examination ◽  
History Of ◽  
The Right

Aims. Metastatic malignant melanoma of the urinary bladder is a rare clinical entity, with only twenty-three published cases to date. We present a case of this rare entity, a thorough review of the literature, and differential diagnosis of melanoma in the bladder.Methods and Results. A 55-year-old woman with a history of malignant melanoma of the right thigh, excised eight years ago, presented with back pain, fatigue, and hematuria. She underwent computed tomography (CT) scan and was found to have metastases within the liver, spleen, lungs, and urinary bladder. She underwent cystoscopy and transurethral resection of three polypoid lesions. Histologic and immunohistochemical examination revealed metastatic malignant melanoma involving bladder mucosa.Conclusions. This case illustrates the importance of including malignant melanoma in the differential diagnosis of high grade neoplasms of bladder, especially in cases where the relevant clinical history is not available.

scholarly journals Primary clear cell adenocarcinoma of cervix in a young women: A rare entity

2016 ◽  
Author(s):  
Nidhi Jain ◽  
Rahul Manchanda ◽  
Anshika Lekhi ◽  
Sravani Chithra ◽  
Hena Kausar
Keyword(s):  
Cervical Cancer ◽  
Young Women ◽  
Clear Cell ◽  
Uterine Cavity ◽  
In Utero ◽  
Clear Cell Adenocarcinoma ◽  
Vascular Growth ◽  
Gynaecological Malignancy ◽  
History Of ◽  
Diagnostic Hysteroscopy

Cervical cancer is the most common gynaecological malignancy worldwide. The most common type of cervical carcinoma is squamous cell carcinoma followed by adenocarcinoma of cervix, which constitutes only 15% of cases. Adenocarcinoma of cervix can be categorized histologically into clear cell, mucinous, endometrioid, serous and mesonephric subtypes. Clear cell adenocarcinoma (CCA) most commonly occurs in the ovary, followed by endometrium, vagina, and cervix. Primary CCA of cervix is a rare neoplastic entity, which occurs in young women exposed to diethylstilbestrol (DES) in utero. It is extremely rare in women without in utero DES exposure and in such cases it concerns mostly postmenopausal women. Here, we present a case of 30 year old woman who presented with primary infertility. There was no history of in-utero exposure to diethyl stilbestrol. She was diagnosed a case of cervical fibroid on ultrasonography. Diagnostic hysteroscopy was done and she was found to have friable, vascular growth in endocervix, which was extending to uterine cavity. Biopsy was taken. On histopathology, moderately differentiated clear cell adenocarcinoma of cervix was reported. Through this case, authors would like to highlight the probability of rare occurrence and how to manage challenges posed by cervical cancer in young girl wishing to conceive, stressing on the role of hysteroscopy in diagnosis.

scholarly journals Late Recurrence in Ovarian Dysgerminoma Presenting as a Primary Retroperitoneal Tumor: A Case Report and Review of the Literature

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Yuichiro Sato ◽  
Tohru Hayashi ◽  
Hidetaka Yamamoto ◽  
Ichiro Niina ◽  
Naoya Kuroki ◽  
...  
Keyword(s):  
Clinical History ◽  
Late Recurrence ◽  
Retroperitoneal Tumor ◽  
Retroperitoneal Mass ◽  
Review Of The Literature ◽  
Rare Type ◽  
History Of ◽  
Node Metastases ◽  
Ovarian Dysgerminoma ◽  
Primary Retroperitoneal

Ovarian dysgerminoma is a rare type of germ cell tumor. The majority of patient relapses occur within 2 years of diagnosis. Here, we report the case of a 74-year-old woman with a history of ovarian dysgerminoma 39 years earlier. The patient visited the hospital presenting with heartburn. An abdominal computed tomography (CT) revealed a right retroperitoneal mass, and a primary retroperitoneal tumor was suspected. She underwent surgical resection of the retroperitoneal tumor. Histological examination confirmed a metastatic dysgerminoma to the retroperitoneum. Postoperative CT showed paraaortic and cervical lymph node metastases. The patient was treated with bleomycin, etoposide, and cisplatin chemotherapy. This case demonstrates the difficulties that may be encountered in the differential diagnosis of a retroperitoneal mass and underlines the necessity for understanding a patient’s clinical history.

Malignant Pericardial Mesothelioma. Report of two Cases, Review of the Literature and Differential Diagnosis

2005 ◽  
Vol 91 (3) ◽  
pp. 276-279 ◽  
Author(s):  
Maximilian Papi ◽  
Giovenzio Genestreti ◽  
Davide Tassinari ◽  
Paolo Lorenzini ◽  
Silvia Serra ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Radical Surgery ◽  
Asbestos Exposure ◽  
Distant Metastases ◽  
Review Of The Literature ◽  
Primary Tumors ◽  
Cardiac Neoplasm ◽  
Fibrous Stroma ◽  
Pericardial Mesothelioma ◽  
History Of

Malignant pericardial mesothelioma is an uncommon variety of a primary malignant cardio-pericardial tumor and it is a highly lethal and fortunately rare cardiac neoplasm. The presentation of pericardial mesothelioma is aspecific and pathologically mesothelioma is not the most common among primary tumors of the pericardium. It is characterized by atypical solid growth of mesothelium with formation of atypical cavities surrounded by fibrous stroma. Antemortem diagnosis is difficult and distant metastases are extremely rare. Radical surgery can be used to treat localized mesothelioma. The treatment for advanced primary pericardial mesothelioma is usually palliative because the tumor is resistant to radiotherapy and chemotherapy. The prognosis is unfavorable. The median survival from the onset of symptoms is six months. In this paper we report two cases of patients with primary mesothelioma of the pericardium without a definite history of asbestos exposure.

scholarly journals Distant Ureteral Metastasis from Colon Adenocarcinoma: Report of a Case and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Ferakis Nikolaos ◽  
Anastasopoulos Panagiotis ◽  
Bouropoulos Konstantinos ◽  
Samaras Vassilios ◽  
Poulias Iraklis
Keyword(s):  
Rectal Cancer ◽  
Differential Diagnosis ◽  
Distant Metastasis ◽  
Toxic Megacolon ◽  
Incidental Finding ◽  
Previous History ◽  
Colon Adenocarcinoma ◽  
Review Of The Literature ◽  
Muscular Coat ◽  
History Of

Carcinomas arising from organs neighbouring the ureter can directly infiltrate the ureter. Distant ureteral metastasis from colon adenocarcinoma is extremely rare and usually an incidental finding in performed autopsies. We report a case of a right ureteral metastasis in a 65-year-old Caucasian male with a history of rectal cancer for which he had been treated 4 years before. He presented with asymptomatic moderate right hydronephrosis. The patient underwent a right nephroureterectomy. Histology of the ureter revealed transmural adenocarcinoma with infiltration of the mucosa. Infiltration of the muscular coat of the bladder was found 2 years later. Thus, cystectomy and left ureterocutaneostomy were performed. The patient died 6 months later due to toxic megacolon during chemotherapy. The differential diagnosis of ureteral adenocarcinoma, especially in patients with previous history of colon adenocarcinoma, should include the possibility of distant metastasis from the primary colonic tumor.

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