Cytoplasmic Inclusion Bodies and Minimal Hepatitis: Fibrinogen Storage without Hypofibrinogenemia

2001 ◽  
Vol 4 (3) ◽  
pp. 304-309 ◽  
Author(s):  
Daiki Abukawa ◽  
Yusaku Tazawa ◽  
Tomoyo Noro ◽  
Michiko Nakagawa ◽  
Kazuie Iinuma ◽  
...  
Keyword(s):  
Inclusion Bodies ◽  
Periodic Acid ◽  
Plasma Concentrations ◽  
Cytoplasmic Inclusion ◽  
Clotting Factors ◽  
Periodic Acid Schiff ◽  
Transmission Electron ◽  
Eosinophilic Inclusion ◽  
Old Japanese ◽  
Cytoplasmic Inclusion Bodies

A 12-year-old Japanese boy had chronic elevation and fluctuation of serum transaminase levels since infancy, with no signs or symptoms of liver failure. Usual infections or metabolic disorders were eliminated from consideration. No coagulopathy or abnormality in plasma concentrations of clotting factors was found. Light microscopy of liver biopsy specimens obtained at ages 2,5, and 7 years showed slight hepatocyte disarray and minimal mononuclear-leukocyte lobular inflammation, with eosinophilic inclusion bodies in the cytoplasm of hepatocytes throughout the lobule. These bodies stained with the periodic acid-Schiff (PAS) technique; the PAS-positive material was partly diastase digestible and on immunostaining marked for fibrinogen but not for α1-antitrypsin. On transmission electron microscopy, the bodies were represented by finely granular material contained within membranes and were interpreted as tentatively endoplasmic reticulum. Fibrinogen storage may be manifest as minimal hepatitis without coagulopathy.

Morphology and Other Prognostic Factors of Hepatocellular Carcinoma

1999 ◽  
Vol 123 (6) ◽  
pp. 524-528
Author(s):  
Antonio Chedid ◽  
Louise M. Ryan ◽  
Yogeshwar Dayal ◽  
Barbara C. Wolf ◽  
Geoffrey Falkson
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Factors ◽  
Blood Vessel ◽  
Inclusion Bodies ◽  
Cytoplasmic Inclusion ◽  
Primary Hepatocellular Carcinoma ◽  
Blood Vessel Invasion ◽  
Vessel Invasion ◽  
Eosinophilic Inclusion ◽  
Cytoplasmic Inclusion Bodies

Abstract Objective.—Hepatocellular carcinoma is a malignancy found worldwide that has typically poor prognosis despite treatment. Although several studies have dealt with prognostic factors, just a few detailed analyses of large series correlating the pathology of hepatocellular carcinoma with prognosis are available. The present study was undertaken to address this limitation. Patients and Methods.—Our prior clinical study described 432 patients, but sufficient tissue was available for evaluation in only 299 patients. Of these, 224 samples contained primary hepatocellular carcinoma, while the remainder contained only metastatic tumor. Characteristics evaluated included degree of tumor differentiation, associated cirrhosis or hepatitis, presence of cytoplasmic inclusion bodies, and blood vessel invasion by the neoplasm. Results.—Of the 224 patients, 71% were male, 65% white, and 73% over the age of 45 years. Ninety-one percent were from North America. A total of 42 patients were found to have cirrhosis. Thirty-five percent had cytoplasmic inclusion bodies, and 25% showed evidence of blood vessel invasion. Tumor response rates (tumor shrinkage) were low (8%) regardless of treatment. Presence of cytoplasmic eosinophilic inclusion bodies and blood vessel invasion were not associated with increased survival. Some histopathologies (pelioid, spindle cell, fibrolamellar) were associated with a better prognosis. Patients with a predominant trabecular pattern (43%) did particularly poorly. Although sex was significantly associated with survival using a univariate analysis, this effect disappeared in a multivariate Cox model that adjusted simultaneously for other factors. Conclusion.—This investigation suggests that histologic subtype and clinical features may provide useful prognostic information in hepatocellular carcinoma. Poorer survival was observed in males, older patients with poorly differentiated tumors, or when associated with cirrhosis. Age younger than 45 years was a good prognostic factor, and presence of cirrhosis had an adverse effect on survival.

Enterogenous cyst in the cervical spinal canal

1988 ◽  
Vol 68 (2) ◽  
pp. 292-296 ◽  
Author(s):  
Kouichi Miyagi ◽  
Jiro Mukawa ◽  
Susumu Mekaru ◽  
Yasunari Ishikawa ◽  
Toshihiko Kinjo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Immunohistochemical Staining ◽  
Periodic Acid ◽  
Enterogenous Cyst ◽  
Resonance Imaging ◽  
Periodic Acid Schiff ◽  
Content Type ◽  
Low Intensity ◽  
Old Japanese ◽  
Fine Print

✓ The case of an 11-year-old Japanese girl with an intradural and extramedullary enterogenous cyst is presented. A mass giving a low-intensity signal in comparison with the spinal cord was demonstrated on magnetic resonance imaging. Histologically, the diagnosis was confirmed on specimens stained with periodic acid-Schiff, alcian blue, mucicarmine, and immunohistochemical staining of carcinoembryonic antigen, and by electron microscopy.

scholarly journals Searching for the cause of Kawasaki disease — cytoplasmic inclusion bodies provide new insight

2008 ◽  
Vol 6 (5) ◽  
pp. 394-401 ◽  
Author(s):  
Anne H. Rowley ◽  
Susan C. Baker ◽  
Jan M. Orenstein ◽  
Stanford T. Shulman
Keyword(s):  
Kawasaki Disease ◽  
Inclusion Bodies ◽  
Cytoplasmic Inclusion ◽  
Cytoplasmic Inclusion Bodies

scholarly journals Peste Des Petits Ruminants Virus and Goatpox Virus Co-Infection in Goats

2020 ◽  
Vol 57 (4) ◽  
pp. 550-553
Author(s):  
Olatunde Babatunde Akanbi ◽  
Kati Franzke ◽  
Adeyinka Jeremy Adedeji ◽  
Reiner Ulrich ◽  
Jens Peter Teifke
Keyword(s):  
Small Ruminants ◽  
Cytoplasmic Inclusion ◽  
Economic Consequences ◽  
Peste Des Petits Ruminants ◽  
Cytoplasmic Inclusions ◽  
Goatpox Virus ◽  
Transmission Electron ◽  
Cytoplasmic Inclusion Bodies ◽  
Red Sokoto Goat ◽  
First Time

Infection of small ruminants with peste des petits ruminants virus (PPRV) and goatpox virus (GTPV) are endemic and can have devastating economic consequences in Asia and Africa. Co-infection with these viruses have recently been reported in goats and sheep in Nigeria. In this study, we evaluated samples from the lips of a red Sokoto goat, and describe co-infection of keratinocytes with PPRV and GTPV using histopathology and transmission electron microscopy. Eosinophilic cytoplasmic inclusion bodies were identified histologically, and ultrastructural analysis revealed numerous large cytoplasmic viral factories containing poxvirus particles and varying sizes of smaller cytoplasmic inclusions composed of PPRV nucleocapsids. These histopathological and ultrastructural findings show concurrent infection with the 2 viruses for the first time as well as the detection of PPRV particles in epithelial cells of the mucocutaneous junction of the lip.

Distinctive eosinophilic cytoplasmic inclusion bodies in melanocytic nevi: an immunohistochemical and ultrastructural study

2011 ◽  
Vol 38 (11) ◽  
pp. 865-870 ◽  
Author(s):  
Wonwoo Shon ◽  
David A. Wada ◽  
Lawrence E. Gibson ◽  
Thomas J. Flotte ◽  
Bernd W. Scheithauer
Keyword(s):  
Ultrastructural Study ◽  
Inclusion Bodies ◽  
Cytoplasmic Inclusion ◽  
Melanocytic Nevi ◽  
Cytoplasmic Inclusion Bodies
Sign in / Sign up

Export Citation Format

Share Document