Tissue integration and inflammatory reaction in full-thickness abdominal wall repair using an innovative composite mesh

Hernia ◽  
2015 ◽  
Vol 20 (4) ◽  
pp. 607-622 ◽  
Author(s):  
G. Pascual ◽  
S. Sotomayor ◽  
M. Rodríguez ◽  
Y. Bayon ◽  
J. M. Bellón
Keyword(s):  
Abdominal Wall ◽  
Inflammatory Reaction ◽  
Composite Mesh ◽  
Full Thickness ◽  
Abdominal Wall Repair ◽  
Tissue Integration

A simple technique of laparoscopic full-thickness anterior abdominal wall repair of retrosternal (Morgagni) hernias

2003 ◽  
Vol 38 (5) ◽  
pp. 768-770 ◽  
Author(s):  
Georges Azzie ◽  
Kiki Maoate ◽  
Spencer Beasley ◽  
Wilhelm Retief ◽  
Arie Bensoussan
Keyword(s):  
Abdominal Wall ◽  
Simple Technique ◽  
Anterior Abdominal Wall ◽  
Full Thickness ◽  
Abdominal Wall Repair

scholarly journals Squid Ring Teeth Coated Mesh Improves Abdominal Wall Repair

2017 ◽  
Author(s):  
Ashley N. Leberfinger ◽  
Monika Hospodiuk ◽  
Abdon Pena-Francesch ◽  
Bugra Ayan ◽  
Veli Ozbolat ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Hernia Repair ◽  
Abdominal Wall ◽  
Abdominal Wall Defect ◽  
High Strength ◽  
Composite Mesh ◽  
Standard Material ◽  
Tissue Integration

ABSTRACTBackgroundHernia repair is a common surgical procedure with mesh often used. Current mesh materials have a high incidence of repair failures, due to poor tissue integration, and complications such as seroma and pain. Polypropylene (PP) mesh is the standard material in hernia repair secondary to its material durability; however, failures still approach 15%. In this first time animal study, we hypothesized that squid ring teeth (SRT), a biologically-derived high strength protein, coated polypropylene (SRT-PP) mesh, would offer enhanced tissue integration and strength compared to standard PP mesh, while proving biocompatibility for in vivo use.Materials and methodsPolypropylene mesh was coated with SRT. Mechanical properties and cell proliferation studies of the composite mesh were performed in vitro. Rats underwent inlay mesh implantation in an anterior abdominal wall defect model. Repair was assessed clinically and radiographically, with integration evaluated by histology and mechanical testing.ResultsCell proliferation was enhanced on SRT-PP composite mesh. This was corroborated by abdominal wall histology, dramatically diminished cranio-caudal mesh contraction, improved strength testing, and higher tissue failure strain following in vivo implantation. There was no increase in complications with SRT, with regard to seroma or visceral adhesion. No foreign body reactions were noted on liver histology.ConclusionSRT-PP mesh showed better tissue integration than PP mesh. SRT is a high strength protein that is applied as a coating to augment mesh-tissue integration leading to improvements in abdominal wall stability with potential to reduce re-intervention for failures.

scholarly journals Behaviour of a New Composite Mesh for the Repair of Full-Thickness Abdominal Wall Defects in a Rabbit Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e80647 ◽  
Author(s):  
Gemma Pascual ◽  
Sandra Sotomayor ◽  
Marta Rodríguez ◽  
Yves Bayon ◽  
Juan M. Bellón
Keyword(s):  
Abdominal Wall ◽  
Rabbit Model ◽  
Abdominal Wall Defects ◽  
Composite Mesh ◽  
Full Thickness

Determination of clinical efficiency of deproteinized dialysate from blood of milk-fed calves after endoprosthetics in patients with ventral hernias

2020 ◽  
Vol 28 (3) ◽  
pp. 323-333
Author(s):  
Sergej V. Ivanov ◽  
Ilya S. Ivanov ◽  
Evgenij G. Obyedkov ◽  
Liliya P. Popova
Keyword(s):  
Abdominal Wall ◽  
Inflammatory Reaction ◽  
Inflammatory Process ◽  
Anterior Abdominal Wall ◽  
Dynamic Change ◽  
Main Group ◽  
Control Group ◽  
Surgical Department ◽  
Regeneration Stage

Aim. To study the influence of deproteinized dialysate from blood of milk-fed calves on the type of exudative discharge and dynamics of inflammatory reaction after hernia repair with plastics of the anterior abdominal wall with hernioendoprosthesis of polypropylene. Materials and Methods. The study involved 59 patients being on stationary treatment in the surgical department of Kursk Regional Clinical Hospital. Patients were hospitalized for the herniation of small or medium dimension. The patients were divided to two groups: the main (n=30) and control (n=29) groups. After endoprosthetics, the patients of the control group were given complex conservative treatment. The patients of the main group, besides standard treatment, were administered deproteinized dialysate from blood of milk-fed calves intravenously in drips 10 ml + 200 ml of 0.9% sodium chloride solution within 7 days. For cytological examination and determination of the type of cytograms, the traumatic discharge was collected and analyzed using the method of M.F. Kamaev and M.A. Palthsev. Results. Cytomorphometric examination was conducted on the third, fifth and seventh day after endoprosthetics with the aim of studying dynamic changes. Determination of cell composition and also of its changes characteristic of each studied period, was necessary for obtaining further information characterizing inflammatory process in the region of placement of the endoprosthesis. After endoprosthetics in patients who were administered hemodialysate, the inflammatory reaction was less pronounced than in patients who did not receive the preparation. This was associated with a more dynamic change of stages of the inflammatory process. In patients of the main group who received deproteinized dialysate, regenerative type of inflammation first appeared on the fifth day and made 6.9%; by the seventh day the share of patients with the regenerative type rose to 17.5%, while in the patients of the control group no regeneration stage was observed in both periods. Conclusion. Analysis of the efficiency of influence of hemodialysate on the inflammatory reaction in plastics of the anterior abdominal wall with polypropylene endoprosthesis evidences faster course of all stages of inflammation and reduction of its intensity by 10%.

scholarly journals In vivo evaluation of acellular human dermis for abdominal wall repair

2009 ◽  
pp. n/a-n/a ◽  
Author(s):  
Daniel Eberli ◽  
Sergio Rodriguez ◽  
Anthony Atala ◽  
James J. Yoo
Keyword(s):  
Abdominal Wall ◽  
In Vivo Evaluation ◽  
Abdominal Wall Repair ◽  
Human Dermis

Bio‐Multifunctional Hydrogel Patches for Repairing Full‐Thickness Abdominal Wall Defect

2021 ◽  
pp. 2105614
Author(s):  
Xiangyi Yin ◽  
Yuanping Hao ◽  
Yun Lu ◽  
Dongjie Zhang ◽  
Yaodong Zhao ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Abdominal Wall Defect ◽  
Full Thickness ◽  
Wall Defect

Large Gaps of Midline Abdominal Incisions and Their Management

2008 ◽  
Vol 74 (11) ◽  
pp. 1094-1099
Author(s):  
Mahmoud N. Kulaylat ◽  
Constantine P. Karakousis
Keyword(s):  
Abdominal Wall ◽  
Surgical Procedures ◽  
Skin Grafting ◽  
Operative Management ◽  
Full Thickness ◽  
Tension Free ◽  
Abdominal Malignancy ◽  
One Step ◽  
Short And Long Term

The operative management of midline full-thickness abdominal wall gaps is difficult, often requires several surgical procedures and is associated with significant short- and long-term complications. A rectus abdominis-posterior sheath (RAPS) flap with skin grafting provides a tension-free one-step repair which was used in three patients successfully with midline abdominal wall (including the skin) gaps who had multiple previous operations related to intra-abdominal malignancy. No complications occurred in these patients in relation to this procedure.

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