Sarcoidosis with high serum levels of vascular endothelial growth factor (VEGF), showing RS3PE-like symptoms in extremities

2004 ◽  
Vol 23 (3) ◽  
pp. 246-248 ◽  
Author(s):  
Masayuki Matsuda ◽  
Kumi Sakurai ◽  
Tomohisa Fushimi ◽  
Kanji Yamamoto ◽  
Shiho Rokuhara ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Serum Levels ◽  
High Serum ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals VASCULAR ENDOTHELIAL GROWTH FACTOR AND HLA-PHENOTYPE IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS

2016 ◽  
pp. 16-21
Author(s):  
М. Kolesnyk ◽  
V. Driyanska ◽  
М. Velychko ◽  
G. Drannik ◽  
V. Nepomnyaschiy ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Hla Antigens ◽  
Serum Levels ◽  
High Serum ◽  
Chronic Glomerulonephritis ◽  
Vascular Endothelial ◽  
High Serum Level ◽  
Hla Phenotype ◽  
Endothelial Growth Factor

It was to determine associations the serum levels ofVEGF and with HLA inpatients with chronic glomerulonephritis and nephrotic syndrome (CGN, NS). Materials and methods. There was studied the serum levels of VEGF (80 patients) by ELIZA and HLA-antigens distribution in the CGN, NS patients (534) by typing the lymphocytes with the aid of standard microlymphocytotoxic test (Terasaki’s test). The diagnosis was confirmed morphologically using by nephrobiopsy. Results. The distribution of HLA-A, В antigens of the 2 group patients having the CGN, NS with various serum levels of VEGF is shown. Associations of some HLA-antigens and high levels of vascular endothelial growth factor in blood were noted. Conclusion. High serum level VEGF and HLA-A9, A10 (25+26) and B8 in CGN, NS patients associated with steroidoresistence.

361: Serum Levels of Angiogenin and Vascular Endothelial Growth Factor (VEGF) Predict Metastatic Disease in Renal Cell Cancer Patients

2005 ◽  
Vol 173 (4S) ◽  
pp. 99-99 ◽  
Author(s):  
Marcus Horstmann ◽  
Axel S. Merseburger ◽  
Markus A. Kuczyk ◽  
Arnulf Stenzl ◽  
Karl-Horst Bichler ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cancer Patients ◽  
Renal Cell Cancer ◽  
Metastatic Disease ◽  
Renal Cell ◽  
Cell Cancer ◽  
Serum Levels ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Female sexual dysfunction in systemic sclerosis: The role of endothelial growth factor and endostatin

2018 ◽  
Vol 4 (1) ◽  
pp. 71-76 ◽  
Author(s):  
Antonietta Gigante ◽  
Luca Navarini ◽  
Domenico Margiotta ◽  
Biagio Barbano ◽  
Antonella Afeltra ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Blood Flow ◽  
Systemic Sclerosis ◽  
Growth Factor ◽  
Sexual Dysfunction ◽  
Resistive Index ◽  
Serum Levels ◽  
Vascular Endothelial ◽  
Healthy Controls ◽  
Endothelial Growth Factor

Introduction: Since female sexual dysfunction in systemic sclerosis women is multifactorial, we can assume that vascular damage may play a role in pathogenesis. The aim of the study was to evaluate the clitoral blood flow, by Echo color Doppler, and to correlate it whit serum levels of vascular endothelial growth factor and endostatin. Methods: A total of 15 systemic sclerosis women and 10 healthy controls matched for sex and age were enrolled in this study. Serum VEGF165 and endostatin levels were determined in systemic sclerosis patients by commercial enzyme-linked immunosorbent assay kit. Clitoral blood flow was measured by Doppler indices of clitoral artery: pulsatile index, resistive index, and systolic/diastolic ratio were measured. Sexual dysfunction was assessed by Female Sexual Function Index. Results: Vascular endothelial growth factor (pg/mL) and endostatin (ng/mL) median values were significantly higher in systemic sclerosis women than healthy controls. Resistive index and systolic/diastolic ratio median values were significantly higher in systemic sclerosis women than healthy controls. Negative correlation exists between serum levels of vascular endothelial growth factor and resistive index (r = −0.55, p < 0.05). Positive correlation was observed between serum levels of endostatin and resistive index (r = 0.70, p < 0.01) and systolic/diastolic ratio (r = 0.77, p < 0.01). Discussion: We can suppose that clitoral blood flow in systemic sclerosis women is reduced not only for macro- and microvascular damage but also for impaired angiogenesis.

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