scholarly journals Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet

2016 ◽  
Vol 25 (3) ◽  
pp. 855-860 ◽  
Author(s):  
Hyun-Ju Kang ◽  
Pichiah Balasubramanian Tirupathi Pichiah ◽  
Ravichandran Vijaya Abinaya ◽  
Hee-Sook Sohn ◽  
Youn-Soo Cha
2012 ◽  
Vol 7 (1) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Entisar K. Al-Hallaq ◽  
Fatma U. Afifi ◽  
Shtaywy S. Abdalla

Chemical screening of the leaves and flowers of Crataegus aronia resulted in the isolation of hyperoside, quercetin, rutin and β-sitosterol for the first time from this plant. The effects of the hydroethanolic extract of C. aronia (CAHE) on hypercholesterolemic rats were investigated. The rats, treated orally for four weeks with 400 mg/kg/day CAHE, exhibited significant decreases in serum total cholesterol (TC) and low-density lipoprotein (LDL). The results were compared with those obtained after oral administration of atorvastatin (10 mg/kg/day). Furthermore, 10-week daily co-administration of a high cholesterol diet and CAHE (200 mg/kg/day) prevented the increase in TC and LDL. These observations indicate that CAHE has a hypocholesterolemic effect.


2018 ◽  
Vol 30 (4) ◽  
pp. 288 ◽  
Author(s):  
Mohammed A. Yahya ◽  
Omar A. Alhaj ◽  
Abdullrahman S. AL-Khalifah ◽  
Ahmad T. Almnaizel

The effects of fermented skim milk versus unfermented skim milk of camel on the levels of cholesterol in blood were investigated in rats. Levels of serum cholesterol and LDL-C/ HDL-C ratio were decreased significantly in Wistar rats that fed with a cholesterol-enriched diet and administered fermented skim camel milk compared with rats administered unfermented milk (P˂0.05). Furthermore, histopathological evaluation showed that liver tissue degeneration, apoptosis/necrosis, inflammation, and fatty changes (steatosis and fibrosis) decreased significantly at (P˂0.05) in the rats that fed with fermented skim camel milk compared to the rats which fed unfermented skim camel milk. Based on these results it can suggest that fermented skim camel milk might reduce the risk of hypercholesterolemia development in rats. The hypocholesterolemic and hepatoprotective effects of fermented skim camel milk were evident.


2009 ◽  
Vol 73 (1) ◽  
pp. 205-208 ◽  
Author(s):  
Akiko SHIMIZU-IBUKA ◽  
Haruhide UDAGAWA ◽  
Kazuo KOBAYASHI-HATTORI ◽  
Kiyoshi MURA ◽  
Chiyoko TOKUE ◽  
...  

2014 ◽  
Vol 5 (6) ◽  
pp. 1224-1231 ◽  
Author(s):  
Imen Lassoued ◽  
Mariem Trigui ◽  
Zohra Ghlissi ◽  
Rim Nasri ◽  
Kamel Jamoussi ◽  
...  

The present study attempts to investigate the potential ofBoops boopsproteins and its hydrolysate in the prevention of hypercholesterolemia and oxidative stress in rats fed a high cholesterol diet.


2003 ◽  
Vol 8 (1) ◽  
pp. 13-18
Author(s):  
Hye-Kyung Kim ◽  
Young-Jeong Chang ◽  
Ho-Jin Heo ◽  
Hong-Yon Cho ◽  
Bum-shik Hong ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Jian-Hong Wu ◽  
Qing-Hua Wang ◽  
Fan Li ◽  
Yuan-Lan Shu ◽  
Chi-On Chan ◽  
...  

Consumption of functional foods for lowering serum cholesterol has globally gained acceptance by the general public. Turtle jelly (TJ), also called gui-ling-gao, is a popular traditional functional food in southern China. The hypocholesterolemic effect of consuming TJ was investigated in rats fed with normal diet, high-cholesterol diet or high-cholesterol diet supplemented with simvastatin (3 mg/kg bw per day, p.o.) or TJ (3.3 or 10 mL/kg bw per day, p.o.) for 30 days. TJ markedly reversed the increased serum total cholesterol, increased high-density lipoprotein, and decreased high-density lipoprotein induced by hypercholesterolemic diet with a dose-dependent improvement on the atherogenic index. It also demonstrated good hepatoprotective function by reducing fat depositions and overall lipid contents in the liver and increasing the activities of hepatic antioxidative enzymes. The blunted nitric oxide/endothelium-mediated aortic relaxation in rats fed with hypercholesterolemic diet was partially restored after TJ consumption. It is postulated that the hypocholesterolemic effect is the primary beneficial effect given by TJ; it then leads to secondary beneficial effects such as vasoprotective and hepatoprotective functions. The results revealed that TJ could block the downregulation of LDLR and PEPCK and upregulation of PPARαmRNA and protein expressions in the livers of rats fed with hypercholesterolemic diet.


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