scholarly journals Protective effect of Carthamus tinctorius L. seed on oxidative stress and cognitive impairment induced by chronic alcohol consumption in mice

2018 ◽  
Vol 27 (5) ◽  
pp. 1475-1484 ◽  
Author(s):  
Seung Hak Choi ◽  
Ah Young Lee ◽  
Chan Hum Park ◽  
Yu Su Shin ◽  
Eun Ju Cho
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Alcohol Consumption ◽  
Protective Effect ◽  
Carthamus Tinctorius ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption

scholarly journals Regulatory T cells suppress excessive lipid accumulation in alcoholic liver disease

2019 ◽  
Vol 60 (5) ◽  
pp. 922-936 ◽  
Author(s):  
Hongwu Wang ◽  
Ting Wu ◽  
Yaqi Wang ◽  
Xiaoyang Wan ◽  
Junying Qi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
T Cells ◽  
Liver Disease ◽  
Alcohol Consumption ◽  
Regulatory T Cells ◽  
Alcoholic Liver Disease ◽  
Lipid Accumulation ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption ◽  
Alcoholic Fatty Liver

Sensitization of hepatic immune cells from chronic alcohol consumption gives rise to inflammatory accumulation, which is considered a leading cause of liver damage. Regulatory T cells (Tregs) are an immunosuppressive cell subset that plays an important role in a variety of liver diseases; however, data about pathological involvement of Tregs in liver steatosis of alcoholic liver disease (ALD) is insufficient. In mouse models of ALD, we found that increased lipid accumulation by chronic alcohol intake was accompanied by oxidative stress, inflammatory accumulation, and Treg decline in the liver. Adoptive transfer of Tregs relieved lipid metabolic disorder, oxidative stress, inflammation, and, consequently, ameliorated the alcoholic fatty liver. Macrophages are a dominant source of inflammation in ALD. Aberrant macrophage activation and cytokine production were activated during chronic alcohol consumption, but were significantly inhibited after Treg transfer. In vitro, macrophages were co-activated by alcohol and lipopolysaccharide to mimic a condition for alcoholic liver microenvironment. Tregs suppressed monocyte chemoattractant protein-1 and TNF-α production from these macrophages. However, such effects of Tregs were remarkably neutralized when interleukin (IL)-10 was blocked. Altogether, our data uncover a novel role of Tregs in restoring liver lipid metabolism in ALD, which partially relies on IL-10-mediated suppression of hepatic pro-inflammatory macrophages.

Chronic Alcohol Consumption and Cerebral Indices of Oxidative Stress: Is There a Link?

2001 ◽  
Vol 25 (5) ◽  
pp. 717-725 ◽  
Author(s):  
M. E. Gotz ◽  
B. Janetzky ◽  
S. Pohli ◽  
A. Gottschalk ◽  
W. Gsell ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alcohol Consumption ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption

scholarly journals Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2

2015 ◽  
Vol 12 (12) ◽  
pp. 995-999 ◽  
Author(s):  
Jan A. Graw ◽  
Clarissa von Haefen ◽  
Deniz Poyraz ◽  
Nadine Möbius ◽  
Marco Sifringer ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Chronic Alcohol ◽  
Specific Expression ◽  
Chronic Alcohol Consumption ◽  
Tissue Specific ◽  
Tissue Specific Expression

Decreased Hepatotoxicity of Dimethylnitrosamine (DMN) Following Chronic Alcohol Consumption

1980 ◽  
pp. 237-243
Author(s):  
J. Gellert ◽  
F. Moreno ◽  
M. Haydn ◽  
H. Oldiges ◽  
H. Frenzel ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption

scholarly journals Chronic Alcohol Consumption Blunts β-Adrenergic Responsiveness in Left Ventricular Cardiomyocytes

2010 ◽  
Vol 98 (3) ◽  
pp. 518a
Author(s):  
Krista N. Blackwell ◽  
Dennis J. Rozanski ◽  
Dominique C. Renard-Rooney ◽  
Andrew P. Thomas
Keyword(s):  
Alcohol Consumption ◽  
Left Ventricular ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption ◽  
Ventricular Cardiomyocytes
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