scholarly journals Comment on: “Long‑term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer. Gastric Cancer, 2020 Nov 17” by Watanabe et al.

2021 ◽  
Author(s):  
Yaobin Ouyang ◽  
Cong He ◽  
Nonghua Lu
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection

scholarly journals Impact of Comorbidities, Sarcopenia, and Nutritional Status on the Long-Term Outcomes after Endoscopic Submucosal Dissection for Early Gastric Cancer in Elderly Patients Aged ≥ 80 Years

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3598
Author(s):  
Ga Hee Kim ◽  
Kee Don Choi ◽  
Yousun Ko ◽  
Taeyong Park ◽  
Kyung Won Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Early Gastric Cancer ◽  
Nutritional Status ◽  
Elderly Patients ◽  
Endoscopic Submucosal Dissection ◽  
Term Survival ◽  
Factors Associated ◽  
Submucosal Dissection

Background/Aim: We investigated the oncologic outcomes in elderly patients who underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) by focusing on the impact of comorbidities, sarcopenia, and nutritional status. Methods: Between 2005 and 2016, 280 patients aged ≥ 80 years with 289 EGCs underwent ESD at a tertiary care center. The short- and long-term survival outcomes were assessed. Cox regression analysis was used to identify factors associated with survival, including clinicopathologic factors and abdominal muscle area measured by computed tomography. Results: The rates of en bloc, R0, and, curative resection were 99.3%, 90.0%, and 69.2%, respectively. The rates of post-ESD bleeding and perforation rates were 2.1% and 3.1%, respectively, and no cases showed significant life-threatening adverse events. Over a median follow-up period of 70.5 months, the 3- and 5-year overall survival (OS) rates were 89.5% and 77.1%, respectively; of the114 patients who died, only four (3.5%) were due to gastric cancer. A total of 173 (61.8%) had sarcopenia, and they had lower rates of 3-year (88.4% vs. 91.4%) and 5-year (73.1% vs. 84.0%; p = 0.046) OS than did those without sarcopenia. In multivariable analyses, prognostic nutritional index (hazard ratio [HR], 0.93; 95% confidence interval [CI]: 0.90–0.98; p = 0.002) and Charlson comorbidity index (HR 1.19; 95% CI: 1.03–1.37; p = 0.018) were significant factors associated with overall survival. Conclusions: ESD was a feasible and safe therapeutic method to use in elderly patients, whose long-term survival was significantly associated with nutritional status and comorbidities. These results suggest the need for a possible extension of the curative criteria for ESD in elderly patients with EGC.

Long‐term outcomes of endoscopic submucosal dissection versus surgery in early gastric cancer

2019 ◽  
Vol 31 (4) ◽  
pp. 418-424 ◽  
Author(s):  
Mohamed M. Abdelfatah ◽  
Mohamed Barakat ◽  
Dina Ahmad ◽  
Mariam Ibrahim ◽  
Yahia Ahmed ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Long Term Outcomes ◽  
Submucosal Dissection

Sa1644 Outcomes and Long Term Prognosis of Endoscopic Submucosal Dissection for Early Gastric Cancer

2012 ◽  
Vol 75 (4) ◽  
pp. AB232 ◽  
Author(s):  
Ken Ohnita ◽  
Hajime Isomoto ◽  
Kayoko Matsushima ◽  
Yuko Akazawa ◽  
Naoyuki Yamaguchi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection ◽  
Long Term Prognosis

Short- and long-term outcomes of endoscopic submucosal dissection for undifferentiated early gastric cancer

Endoscopy ◽  
2013 ◽  
Vol 45 (09) ◽  
pp. 703-707 ◽  
Author(s):  
Seiichiro Abe ◽  
Ichiro Oda ◽  
Haruhisa Suzuki ◽  
Satoru Nonaka ◽  
Shigetaka Yoshinaga ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Long Term Outcomes ◽  
Submucosal Dissection ◽  
Undifferentiated Early Gastric Cancer ◽  
Short And Long Term
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