Impact of additional resection on new ischemic lesions and their clinical relevance after intraoperative 3 Tesla MRI in neuro-oncological surgery

Abstract Intraoperative MRI (ioMRI) has become a frequently used tool to improve maximum safe resection in brain tumor surgery. The usability of intraoperatively acquired diffusion-weighted imaging sequences to predict the extent and clinical relevance of new infarcts has not yet been studied. Furthermore, the question of whether more aggressive surgery after ioMRI leads to more or larger infarcts is of crucial interest for the surgeons’ operative strategy. Retrospective single-center analysis of a prospective registry of procedures from 2013 to 2019 with ioMRI was used. Infarct volumes in ioMRI/poMRI, lesion localization, mRS, and NIHSS were analyzed for each case. A total of 177 individual operations (60% male, mean age 45.5 years old) met the inclusion criteria. In 61% of the procedures, additional resection was performed after ioMRI, which resulted in a significantly higher number of new ischemic lesions postoperatively (p < .001). The development of new or enlarged ischemic areas upon additional resection could also be shown volumetrically (mean volume in ioMRI 0.39 cm3 vs. poMRI 2.97 cm3; p < .001). Despite the surgically induced new infarcts, mRS and NIHSS did not worsen significantly in cases with additional resection. Additionally, new perilesional ischemia in eloquently located tumors was not associated with an impaired neurological outcome. Additional resection after ioMRI leads to new or enlarged ischemic areas. However, these new infarcts do not necessarily result in an impaired neurological outcome, even when in eloquent brain areas.

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Comparison of healing in forelimb and hindlimb surgically induced core lesions of the equine superficial digital flexor tendon

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.3415/vcot-13-11-0136 ◽

2014 ◽

Vol 27 (05) ◽

pp. 358-365 ◽

Cited By ~ 6

Author(s):

P. R. Van Weeren ◽

C. H. A. Van de Lest ◽

J. Boere ◽

M. Reyes ◽

J. C. Ionita ◽

...

Keyword(s):

Doppler Ultrasound ◽

Clinical Relevance ◽

Flexor Tendon ◽

Healing Process ◽

Tendon Healing ◽

Tendon Injury ◽

Colour Doppler ◽

Post Surgery ◽

Superficial Digital Flexor Tendon ◽

Surgically Induced

SummaryObjective: Even though equine multi-limb tendinopathy models have been reported, it is unknown if fore- and hindlimb tendon healing behave similarly. The aim of this study was to compare the healing process of surgically induced superficial digital flexor tendon (SDFT) core lesions of fore- and hindlimbs in horses.Methods: Tendon core lesions were surgically induced in the SDFT of both fore- and hindlimbs in eight horses. One randomly assigned forelimb and one randomly assigned hindlimb were injected with saline one and two weeks post-surgery. The healing process was monitored clinically and ultrasonographically. After 24 weeks, the tendons were harvested and biochemical, biomechanical and histological parameters were evaluated.Results: Twenty-four weeks post-surgery, the forelimb SDFT lesions had a significantly higher colour Doppler ultrasound vascularization score (p = 0.02) and glycosaminoglycan concentration (p = 0.04) and a significantly lower hydroxylysylpyridinoline content (p = 0.03).Clinical relevance: Our results indicate that fore- and hindlimb SDFT surgically induced lesions exhibit significant differences in several important parameters of tendon healing 24 weeks post-surgery. These differences create significant challenges in using all four limbs and accurately interpreting the results that one might generate. Therefore these findings do not support the use of four-limb models for study of tendon injury until the reasons for these differences are much better understood.

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Survival rates of resin composite restorations in loadbearing situations in posterior teeth

Dental Update ◽

10.12968/denu.2019.46.6.524 ◽

2019 ◽

Vol 46 (6) ◽

pp. 524-536 ◽

Cited By ~ 3

Author(s):

F J Trevor Burke ◽

Louis Mackenzie ◽

Adrian CC Shortall

Keyword(s):

Cohort Studies ◽

Systematic Reviews ◽

Clinical Relevance ◽

Resin Composite ◽

Survival Rates ◽

Inclusion Criteria ◽

Posterior Teeth ◽

Medline Search ◽

Composite Restorations ◽

Amalgam Restorations

The use of resin composite for routine restoration of cavities in posterior teeth is now commonplace, and will increase further following the Minamata Agreement and patient requests for tooth-coloured restorations in their posterior teeth. It is therefore relevant to evaluate the published survival rates of such restorations. A Medline search identified 144 possible studies, this being reduced to 24 when inclusion criteria were introduced. Of these, ten directly compared amalgam and composite, eight were cohort studies, and six were systematic reviews. It was concluded that posterior composites may provide restorations of satisfactory longevity and with survival rates generally similar to those published on amalgam restorations. However, the ability of the operator in placing the restoration may have a profound effect. CPD/Clinical Relevance: With the increasing use of composite for restorations in posterior teeth, it is relevant to note that these may provide good rates for survival.

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Neuronavigation Combined with Electrophysiological Monitoring for Surgery of Lesions in Eloquent Brain Areas in 42 Cases: A Retrospective Comparison of the Neurological Outcome and the Quality of Resection with a Control Group with Similar Lesions

min - Minimally Invasive Neurosurgery ◽

10.1055/s-2003-39334 ◽

2003 ◽

Vol 46 (2) ◽

pp. 65-71 ◽

Cited By ~ 40

Author(s):

T. Reithmeier ◽

M. Krammer ◽

H. Gumprecht ◽

W. Gerstner ◽

C. B. Lumenta

Keyword(s):

Neurological Outcome ◽

Control Group ◽

Brain Areas ◽

Electrophysiological Monitoring ◽

Retrospective Comparison

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Abstract 340: Effect of the 2015 CPR Guidelines for Patients With Out-Of-Hospital Cardiac Arrest Due to Non-Shockable Rhythm: Results From the All-Japan Utstein Registry

Circulation ◽

10.1161/circ.140.suppl_2.340 ◽

2019 ◽

Vol 140 (Suppl_2) ◽

Author(s):

Tsukasa Yagi ◽

Ken Nagao ◽

Eizo Tachibana ◽

Naohiro Yonemoto ◽

Yoshio Tahara ◽

...

Keyword(s):

Cardiac Arrest ◽

Neurological Outcome ◽

Population Based ◽

Inclusion Criteria ◽

Neurological Outcomes ◽

Shockable Rhythm ◽

Initial Rhythm ◽

Favorable Neurological Outcome ◽

Population Based Registry ◽

Hospital Cardiac Arrest

Background: The 2015 cardiopulmonary resuscitation (CPR) guidelines have stressed that high-quality CPR improves survival from cardiac arrest (CA). In particular, the guidelines recommended that it is reasonable for rescuers to perform chest compressions at a rate of 100 to 120/min in adult CA patients. However, it is unknown whether the 2015 guidelines contributed to favorable neurological outcome in adult CA patients. The present study aimed to clarify the effects of the 2015 guidelines in adult CA patients, using the data of the All-Japan Utstein Registry, a prospective, nationwide, population-based registry of out-of-hospital CA (OHCA). Methods: From the data of this registry between 2011 and 2016, we included adult witnessed OHCA patients due to cardiac etiology, who had non-shockable rhythm, PEA and asystole, as an initial rhythm. Study patients were divided into two groups based on the different CPR guidelines; the era of the 2010 guidelines (2010G), and the era of the 2015 guidelines (2015G). The endpoint was the favorable neurological outcome at 30 days after OHCA. Results: The 109,175 patients who met the inclusion criteria comprised 18,764 who received CPR based on 2015G and 90,411 who received CPR based on 2010G. The figure showed favorable neurological outcomes at 30 days in the two groups. In the multivariate analysis, the adjusted odds ratio for 30-day favorable neurological outcome in 2015G patients as compared to 2010G patients was 1.28 (95%CI 1.11-1.46, p<0.001). Conclusion: In the OHCA patients with non-shockable rhythm, the 2015 guidelines were superior to the 2010 guidelines, in terms of neurological benefits.

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Chronic Maxillary Rhinosinusitis of Dental Origin: A Systematic Review of 674 Patient Cases

International Journal of Otolaryngology ◽

10.1155/2014/465173 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 30

Author(s):

Jerome R. Lechien ◽

Olivier Filleul ◽

Pedro Costa de Araujo ◽

Julien W. Hsieh ◽

Gilbert Chantrain ◽

...

Keyword(s):

Systematic Review ◽

Chronic Rhinosinusitis ◽

Clinical Relevance ◽

Dental Treatment ◽

Apical Periodontitis ◽

Odontogenic Cysts ◽

Common Disease ◽

Inclusion Criteria ◽

Dental Origin

Objectives. The aim of this systematic review is to study the causes of odontogenic chronic maxillary rhinosinusitis (CMRS), the average age of the patients, the distribution by sex, and the teeth involved.Materials and Methods. We performed an EMBASE-, Cochrane-, and PubMed-based review of all of the described cases of odontogenic CMRS from January 1980 to January 2013. Issues of clinical relevance, such as the primary aetiology and the teeth involved, were evaluated for each case.Results. From the 190 identified publications, 23 were selected for a total of 674 patients following inclusion criteria. According to these data, the main cause of odontogenic CMRS is iatrogenic, accounting for 65.7% of the cases. Apical periodontal pathologies (apical granulomas, odontogenic cysts, and apical periodontitis) follow them and account for 25.1% of the cases. The most commonly involved teeth are the first and second molars.Conclusion. Odontogenic CMRS is a common disease that must be suspected whenever a patient undergoing dental treatment presents unilateral maxillary chronic rhinosinusitis.

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A Narrative Review of Clinical researches of Acupuncture treatment for Depression using Neuroimaging method: Focusing on SCI papers

Journal of Korean Medicine ◽

10.13048/jkm.21048 ◽

2021 ◽

Vol 42 (4) ◽

pp. 218-231

Author(s):

Dong Hyuk Lee

Keyword(s):

Clinical Trial ◽

Acupuncture Treatment ◽

Neural Mechanism ◽

Neural Substrates ◽

Current Status ◽

Inclusion Criteria ◽

Online Search ◽

Brain Areas ◽

Symptoms Of Depression ◽

Neuroimaging Techniques

Objectives: The purpose of this article was to investigate the current status of clinical studies of acupuncture treatment for depression using neuroimaging method, focusing on SCI papers.Methods: We searched for clinical trial studies of acupuncture treatment for depression using neuroimaging method in the MEDLINE (Pubmed), OASIS, and RISS database. Once the online search was finished, studies were selected manually by the inclusion criteria. Finally, we analyzed the characteristics of selected articles and reviewed the neural substrates of acupuncture treatment in depression.Results: Total eight studies were included in this study. The most frequently utilized modality was functional MRI. The most frequently selected acupoint for depression was GV20. Several studies revealed that acupuncture treatment could improve the symptoms of depression. In this manuscript, we demonstrated that neuroimaging techniques could capture the neural substrates associated with depression and acupuncture treatment may modulate the activation of brain areas which were impaired in depression in a different way from sham acupuncture.Conclusions: Utilizing neuroimaging methods to explore neural mechanism of acupuncture treatment on depression would be helpful in clinical trials and more efforts should be needed in this fields.

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Selected Abstracts of Recent Research in Stuttering

Perspectives on Fluency and Fluency Disorders ◽

10.1044/ffd9.1.5 ◽

1999 ◽

Vol 9 (1) ◽

pp. 5-6

Author(s):

Carrie Bain ◽

Nan Bernstein Ratner

Keyword(s):

Large Volume ◽

Clinical Relevance

Due to the large volume of fluency-related publications since the last column, we have chosen to highlight those articles of highest potential clinical relevance.

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