Two-dimensional lattice Boltzmann study of red blood cell motion through microvascular bifurcation: cell deformability and suspending viscosity effects

2011 ◽  
Vol 11 (3-4) ◽  
pp. 575-583 ◽  
Author(s):  
Wenjuan Xiong ◽  
Junfeng Zhang
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Lattice Boltzmann ◽  
Two Dimensional ◽  
Cell Deformability ◽  
Dimensional Lattice ◽  
Viscosity Effects ◽  
Cell Motion

Lattice Boltzmann Simulation of Healthy and Defective Red Blood Cell Settling in Blood Plasma

2016 ◽  
Vol 138 (5) ◽  
Author(s):  
Z. Hashemi ◽  
M. Rahnama ◽  
S. Jafari
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Lattice Boltzmann ◽  
Settling Velocity ◽  
Immersed Boundary ◽  
Immersed Boundary Methods ◽  
Cell Deformability ◽  
Lattice Boltzmann Simulation ◽  
Fluid Membrane ◽  
Boundary Methods

In this paper, an attempt has been made to study sedimentation of a red blood cell (RBC) in a plasma-filled tube numerically. Such behaviors are studied for a healthy and a defective cell which might be created due to human diseases, such as diabetes, sickle-cell anemia, and hereditary spherocytosis. Flow-induced deformation of RBC is obtained using finite-element method (FEM), while flow and fluid–membrane interaction are handled using lattice Boltzmann (LB) and immersed boundary methods (IBMs), respectively. The effects of RBC properties as well as its geometry and orientation on its sedimentation rate are investigated and discussed. The results show that decreasing frontal area of an RBC and/or increasing tube diameter results in a faster settling. Comparison of healthy and diabetic cells reveals that less cell deformability leads to slower settling. The simulation results show that the sicklelike and spherelike RBCs have lower settling velocity as compared with a biconcave discoid cell.

scholarly journals Simulated Two-dimensional Red Blood Cell Motion, Deformation, and Partitioning in Microvessel Bifurcations

2008 ◽  
Vol 36 (10) ◽  
pp. 1690-1698 ◽  
Author(s):  
Jared O. Barber ◽  
Jonathan P. Alberding ◽  
Juan M. Restrepo ◽  
Timothy W. Secomb
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Two Dimensional ◽  
Cell Motion

scholarly journals A Two-Dimensional Numerical Investigation of Transport of Malaria-Infected Red Blood Cells in Stenotic Microchannels

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Tong Wang ◽  
Yong Tao ◽  
Uwitije Rongin ◽  
Zhongwen Xing
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Flow Characteristics ◽  
Cell Stiffness ◽  
Immersed Boundary ◽  
Cell Aggregates ◽  
Two Dimensional ◽  
Cell Deformability

The malaria-infected red blood cells experience a significant decrease in cell deformability and increase in cell membrane adhesion. Blood hemodynamics in microvessels is significantly affected by the alteration of the mechanical property as well as the aggregation of parasitized red blood cells. In this study, we aim to numerically study the connection between cell-level mechanobiological properties of human red blood cells and related malaria disease state by investigating the transport of multiple red blood cell aggregates passing through microchannels with symmetric stenosis. Effects of stenosis magnitude, aggregation strength, and cell deformability on cell rheology and flow characteristics were studied by a two-dimensional model using the fictitious domain-immersed boundary method. The results indicated that the motion and dissociation of red blood cell aggregates were influenced by these factors and the flow resistance increases with the increase of aggregating strength and cell stiffness. Further, the roughness of the velocity profile was enhanced by cell aggregation, which considerably affected the blood flow characteristics. The study may assist us in understanding cellular-level mechanisms in disease development.

In vitro effects of temperature on red blood cell deformability and membrane stability in human and various vertebrate species

2021 ◽  
pp. 1-10
Author(s):  
Adam Attila Matrai ◽  
Gabor Varga ◽  
Bence Tanczos ◽  
Barbara Barath ◽  
Adam Varga ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Whole Blood ◽  
Mechanical Stability ◽  
Cell Deformability ◽  
Blood Samples ◽  
Effects Of Temperature ◽  
The Way ◽  
Rbc Deformability

BACKGROUND: The effects of temperature on micro-rheological variables have not been completely revealed yet. OBJECTIVE: To investigate micro-rheological effects of heat treatment in human, rat, dog, and porcine blood samples. METHODS: Red blood cell (RBC) - buffer suspensions were prepared and immersed in a 37, 40, and 43°C heat-controlled water bath for 10 minutes. Deformability, as well as mechanical stability of RBCs were measured in ektacytometer. These tests were also examined in whole blood samples at various temperatures, gradually between 37 and 45°C in the ektacytometer. RESULTS: RBC deformability significantly worsened in the samples treated at 40 and 43°C degrees, more expressed in human, porcine, rat, and in smaller degree in canine samples. The way of heating (incubation vs. ektacytometer temperation) and the composition of the sample (RBC-PBS suspension or whole blood) resulted in the different magnitude of RBC deformability deterioration. Heating affected RBC membrane (mechanical) stability, showing controversial alterations. CONCLUSION: Significant changes occur in RBC deformability by increasing temperature, showing inter-species differences. The magnitude of alterations is depending on the way of heating and the composition of the sample. The results may contribute to better understanding the micro-rheological deterioration in hyperthermia or fever.

scholarly journals Multiplexed fluidic plunger mechanism for the measurement of red blood cell deformability

Lab on a Chip ◽  
2015 ◽  
Vol 15 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Marie-Eve Myrand-Lapierre ◽  
Xiaoyan Deng ◽  
Richard R. Ang ◽  
Kerryn Matthews ◽  
Aline T. Santoso ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Heterogeneous Sample ◽  
Red Blood Cell Deformability

Mechanism for multiplexed measurement of single red blood cell deformability to evaluate pathological cells in a heterogeneous sample.

scholarly journals General up to next-nearest-neighbour elasticity of triangular lattices in three dimensions

2006 ◽  
Vol 462 (2073) ◽  
pp. 2695-2713 ◽  
Author(s):  
Cyril Dubus ◽  
Ken Sekimoto ◽  
Jean-Baptiste Fournier
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Triangular Lattice ◽  
Soft Matter ◽  
Rotational Symmetry ◽  
Three Dimensions ◽  
Nearest Neighbour ◽  
Two Dimensional ◽  
Biological Physics ◽  
Crystalline System

We establish the most general form of the discrete elasticity of a two-dimensional triangular lattice embedded in three dimensions, taking into account up to next-nearest-neighbour interactions. Besides crystalline system, this is relevant to biological physics (e.g. red blood cell cytoskeleton) and soft matter (e.g. percolating gels, etc.). In order to correctly impose the rotational invariance of the bulk terms, it turns out to be necessary to take into account explicitly the elasticity associated with the vertices located at the edges of the lattice. We find that some terms that were suspected in the literature to violate rotational symmetry are, in fact, admissible.

Silencing Red Blood Cell Recognition toward Anti-A Antibody by Means of Polyelectrolyte Layer-by-Layer Assembly in a Two-Dimensional Model System†

Langmuir ◽  
2009 ◽  
Vol 25 (24) ◽  
pp. 14071-14078 ◽  
Author(s):  
Sania Mansouri ◽  
Julien Fatisson ◽  
Zhimei Miao ◽  
Yahye Merhi ◽  
Françoise M. Winnik ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Model System ◽  
Layer By Layer ◽  
Cell Recognition ◽  
Two Dimensional ◽  
Dimensional Model ◽  
Polyelectrolyte Layer ◽  
Two Dimensional Model ◽  
Layer Assembly
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