Channel-tunnels: outer membrane components of type I secretion systems and multidrug efflux pumps of Gram-negative bacteria

2003 ◽  
pp. 122-165 ◽  
Author(s):  
C. Andersen
Keyword(s):  
Outer Membrane ◽  
Efflux Pumps ◽  
Type I ◽  
Gram Negative Bacteria ◽  
Multidrug Efflux ◽  
Secretion Systems ◽  
Gram Negative ◽  
Multidrug Efflux Pumps ◽  
Membrane Components

scholarly journals Trans-envelope multidrug efflux pumps of Gram-negative bacteria and their synergism with the outer membrane barrier

2018 ◽  
Vol 169 (7-8) ◽  
pp. 351-356 ◽  
Author(s):  
Helen I. Zgurskaya ◽  
Valentin V. Rybenkov ◽  
Ganesh Krishnamoorthy ◽  
Inga V. Leus
Keyword(s):  
Outer Membrane ◽  
Efflux Pumps ◽  
Gram Negative Bacteria ◽  
Multidrug Efflux ◽  
Gram Negative ◽  
Multidrug Efflux Pumps ◽  
Membrane Barrier

Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance

2014 ◽  
Vol 9 (10) ◽  
pp. 1165-1177 ◽  
Author(s):  
Jessica MA Blair ◽  
Grace E Richmond ◽  
Laura JV Piddock
Keyword(s):  
Antibiotic Resistance ◽  
Efflux Pumps ◽  
Gram Negative Bacteria ◽  
Multidrug Efflux ◽  
Gram Negative ◽  
Multidrug Efflux Pumps

scholarly journals BastionHub: a universal platform for integrating and analyzing substrates secreted by Gram-negative bacteria

2020 ◽  
Vol 49 (D1) ◽  
pp. D651-D659
Author(s):  
Jiawei Wang ◽  
Jiahui Li ◽  
Yi Hou ◽  
Wei Dai ◽  
Ruopeng Xie ◽  
...  
Keyword(s):  
Rapid Development ◽  
Single Type ◽  
Computational Techniques ◽  
Type I ◽  
Gram Negative Bacteria ◽  
Bacterial Survival ◽  
Secretion Systems ◽  
Gram Negative ◽  
Relationship Analysis ◽  
Depth Analysis

Abstract Gram-negative bacteria utilize secretion systems to export substrates into their surrounding environment or directly into neighboring cells. These substrates are proteins that function to promote bacterial survival: by facilitating nutrient collection, disabling competitor species or, for pathogens, to disable host defenses. Following a rapid development of computational techniques, a growing number of substrates have been discovered and subsequently validated by wet lab experiments. To date, several online databases have been developed to catalogue these substrates but they have limited user options for in-depth analysis, and typically focus on a single type of secreted substrate. We therefore developed a universal platform, BastionHub, that incorporates extensive functional modules to facilitate substrate analysis and integrates the five major Gram-negative secreted substrate types (i.e. from types I–IV and VI secretion systems). To our knowledge, BastionHub is not only the most comprehensive online database available, it is also the first to incorporate substrates secreted by type I or type II secretion systems. By providing the most up-to-date details of secreted substrates and state-of-the-art prediction and visualized relationship analysis tools, BastionHub will be an important platform that can assist biologists in uncovering novel substrates and formulating new hypotheses. BastionHub is freely available at http://bastionhub.erc.monash.edu/.

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