scholarly journals Sustained Release of Hydrogen Sulfide (H2S) from Poly(Lactic Acid) Functionalized 4-Hydroxythiobenzamide Microparticles to Protect Against Oxidative Damage

2019 ◽  
Vol 47 (8) ◽  
pp. 1691-1700 ◽  
Author(s):  
Anh-Vu Do ◽  
Rasheid Smith ◽  
Phillip Tobias ◽  
Daniel Carlsen ◽  
Erica Pham ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Lactic Acid ◽  
Oxidative Damage ◽  
Sustained Release ◽  
Poly Lactic Acid

Adsorption and Sustained Release of Insulin from Zinc Hydroxyapatite Microparticle with Poly (Lactic Acid) Coating

2008 ◽  
Vol 396-398 ◽  
pp. 507-510 ◽  
Author(s):  
Toru Tonegawa ◽  
Toshiyuki Ikoma ◽  
Tomohiko Yoshioka ◽  
Kazuo Shinozaki ◽  
Nobutaka Hanagata ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Lactic Acid ◽  
Adsorption Isotherm ◽  
Sustained Release ◽  
Outer Layer ◽  
Poly Lactic Acid ◽  
Initial Release ◽  
Apparent Reduction ◽  
Low Crystalline ◽  
Acid Coating

Insulin delivery carriers using low crystalline porous zinc hydroxyapatite (ZnHAp) microparticles with different crystal sizes and novel formulation method of poly (lactic acid) (PLA) have been developed to achieve the sustained-release of insulin. The adsorption isotherm curves of insulin dissolved into acetic acid of pH4.5 onto ZnHAp nanocrystals show non-Langmuir type due to the dissolution of the ZnHAp microparticles; the adsorption amounts were increased with the increase of crystalline sizes. The PLA formulation, coating the outer layer of microparticles, showed the apparent reduction of initial burst for insulin. The amounts of initial release of insulin decreased with the increase of crystalline sizes of ZnHAp, which could be attributed to the different meso-porous structure depending on its crystal sizes.

Poly(lactic acid) microspheres for the sustained release of antiischemic agents

2002 ◽  
Vol 242 (1-2) ◽  
pp. 115-120 ◽  
Author(s):  
A Dalpiaz ◽  
A Scatturin ◽  
B Pavan ◽  
C Biondi ◽  
M.A Vandelli ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Sustained Release ◽  
Poly Lactic Acid

Poly(lactic acid) microspheres for the sustained release of a selective A1 receptor agonist

2001 ◽  
Vol 73 (2-3) ◽  
pp. 303-313 ◽  
Author(s):  
Alessandro Dalpiaz ◽  
Angelo Scatturin ◽  
Barbara Pavan ◽  
Carla Biondi ◽  
Maria Angela Vandelli ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Sustained Release ◽  
Receptor Agonist ◽  
Poly Lactic Acid ◽  
A1 Receptor

scholarly journals Effect of Hydrophobic Excipients on the Release Behavior of Dexamethasone and Betamethasone from Biodegradable Poly (DL-lactide) Polymeric Implants

1970 ◽  
Vol 45 (3) ◽  
pp. 189-196
Author(s):  
Fariba Khan ◽  
Tasnuva Mahmud ◽  
M Saiful Islam ◽  
Reza-ul Jalil
Keyword(s):  
Lactic Acid ◽  
Sustained Release ◽  
Sodium Phosphate ◽  
In Vitro Dissolution ◽  
Poly Lactic Acid ◽  
Release Mechanism ◽  
Biodegradable Poly ◽  
Sorbitan Esters ◽  
Betamethasone And Dexamethasone

This study was conducted with the aim of formulating injectable in-situ forming implants of biodegradable poly (D,L-poly lactic acid) (DLPLA) with steroidal drugs. Two steroidal drugs betamethasone sodium phosphate and dexamethasone sodium phosphate were selected as model drug. Different hydrophobic excipients such as sorbitan esters of lauric acid (Span 20), sorbitan esters of oleic acid (Span 80), cetyl alcohol, glyceryl monostearate, glyceryl dibehenate (CompritolAT088®), glyceryl palmito-stearic ester (Precirol®) were used. In-vitro dissolution of 7 days was performed to investigate the effect of these excipients on the release of betamethasone and dexamethasone from insitu forming DL-PLA implants. Drug release data were fitted in different models to characterize release mechanism. Both betamethasone and dexamethasone release were found to follow Korsmeyer model. Glyceryl palmitostearate was found to reduce the release of both betamethasone and dexamethasone most. Time for 25% release (t25), 50% release (t50), and 75% release (t75) of the drugs were calculated. Mean dissolution time (MDT) values were also calculated from the dissolution data. MDT (day) was 2.48±0.2 and 2.31±0.3 for betamethasone and dexamethasone respectively for implants containing no excipient. Incorporation of all the excipients (except span 20) increased these MDT values for both of the drugs indicating sustained release nature of the excipients. Key words: In-situ implants; Poly (D,L-lactic acid); Betamethasone; Dexamethasone; Hydrophobic excipients; Sustained release DOI: 10.3329/bjsir.v45i3.6527Bangladesh J. Sci. Ind. Res. 45(3), 189-196, 2010

Preparation of Urea Slow Release Membrane Environment Friendly

2012 ◽  
Vol 482-484 ◽  
pp. 1618-1621 ◽  
Author(s):  
Shu Jiang Wang ◽  
Xing Quan Wang ◽  
Ming Hui Chen
Keyword(s):  
Lactic Acid ◽  
Sustained Release ◽  
Corn Starch ◽  
Slow Release ◽  
Urea Formaldehyde ◽  
Raw Material ◽  
Poly Lactic Acid ◽  
Dialdehyde Starch ◽  
Membrane Absorption ◽  
High Efficient

First, the corn starch was taken as raw material, and then it was broken down by enzymes and fermentation by lactic acid bacteria, and the poly lactic acid was obtained by chemical synthesis. Then the corn starch was taken as raw material again, the dialdehyde starch was obtained by high efficient light-catalytic reactor. Secondly, a certain percentage of dialdehyde starch and urea were mixed together to get urea-formaldehyde resin. Finally, a certain amount of polylactic acid, urea formaldehyde resins and dispersions were put together and mixed in a high-speed stirring to get urea slow release membrane materials. Experimental results showed that it needed 150-300 days degradate completely by 75% poly lactic acid sustained release membrane, while 85% needed 100 -120 days. Single thin membrane absorption test showed that per unit area of the sustained release membrane absorption ability would increase with the poly lactic acid increased, and the absorbent capacity of 85% poly lactic acid of sustained release membrane was 112 times higher than the mass of itself.

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